PP2A Cancerous-IN-1
Based on 1 Customer Validation
PP2A Cancerous-IN-1 is a strong and potent CIP2A (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities. PP2A Cancerous-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 1403933-79-8
- Formula: C30H24N4O3
- Molecular Weight:488.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
CIP2A and p-Akt[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-HEP1 | IC50 |
2.8 μM
Compound: 19
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Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 48 hrs by MTT assay
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[PMID: 22980218] |
In Vitro
PP2A Cancerous-IN-1 (2.5 and 5 μM; 24 hours; SK-Hep-1 cells) reduces CIP2A expression and cell viability with a dose dependent manner and is more potent in its action than erlotinib[1].
PP2A Cancerous-IN-1 (5 μM; 24 hours; SK-Hep-1 cells) induces cell apoptosis[1].
PP2A Cancerous-IN-1 shows CIP2A inhibitory activity, reduces p-Akt level, induces PARP cleavage. PP2A Cancerous-IN-1 exhibits high potency with low IC50 values of 2.8 μM against HCC cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-Hep-1 cells
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Concentration:2.5 and 5 μM
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Incubation Time:24 hours
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Result:Reduced cell viability with a dose dependent manner.
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Cell Line:SK-Hep-1 cells
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Concentration:2.5 and 5 μM
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Incubation Time:24 hours
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Result:Reduced CIP2A expression.
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Cell Line:SK-Hep-1 cells
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Concentration:2.5 and 5 μM
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Incubation Time:24 hours
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Result:Induced cell apoptosis.
Chemical Information
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CAS No. 1403933-79-8
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Molecular Weight 488.54
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Formula C30H24N4O3
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SMILES
C#CC1=CC=CC(NC2=C3C=C(OC)C(OC)=CC3=NC(NC4=CC=C(C=C4)OC5=CC=CC=C5)=N2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 5 mg/mL (10.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0469 mL | 10.2346 mL | 20.4692 mL | 51.1729 mL |
| 5 mM | 0.4094 mL | 2.0469 mL | 4.0938 mL | 10.2346 mL | |
| 10 mM | 0.2047 mL | 1.0235 mL | 2.0469 mL | 5.1173 mL |
PP2A Cancerous-IN-1 Related Classifications
HY-139296 Related Classifications
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