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Cat. No.: HY-139296

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PP2A Cancerous-IN-1

PP2A Cancerous-IN-1 is a strong and potent CIP2A (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities. PP2A Cancerous-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

CAS No.: 1403933-79-8
Formula: C₃₀H₂₄N₄O₃
Molecular Weight:488.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

PP2A Cancerous-IN-1 Chemical Structure

CAS No.: 1403933-79-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PP2A Cancerous-IN-1 is a strong and potent CIP2A (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities^[1]. PP2A Cancerous-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

CIP2A and p-Akt^[1]

All Akt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
SK-HEP1	IC₅₀	2.8 μM Compound: 19	Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22980218]

In Vitro

PP2A Cancerous-IN-1 (2.5 and 5 μM; 24 hours; SK-Hep-1 cells) reduces CIP2A expression and cell viability with a dose dependent manner and is more potent in its action than erlotinib^[1].
PP2A Cancerous-IN-1 (5 μM; 24 hours; SK-Hep-1 cells) induces cell apoptosis^[1].
PP2A Cancerous-IN-1 shows CIP2A inhibitory activity, reduces p-Akt level, induces PARP cleavage. PP2A Cancerous-IN-1 exhibits high potency with low IC50 values of 2.8 μM against HCC cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SK-Hep-1 cells
Concentration:

2.5 and 5 μM
Incubation Time:

24 hours
Result:

Reduced cell viability with a dose dependent manner.

Western Blot Analysis^[1]

Cell Line:

SK-Hep-1 cells
Concentration:

2.5 and 5 μM
Incubation Time:

24 hours
Result:

Reduced CIP2A expression.

Apoptosis Analysis^[1]

Cell Line:

SK-Hep-1 cells
Concentration:

2.5 and 5 μM
Incubation Time:

24 hours
Result:

Induced cell apoptosis.

Chemical Information

CAS No. 1403933-79-8
Molecular Weight 488.54
Formula C₃₀H₂₄N₄O₃
SMILES

C#CC1=CC=CC(NC2=C3C=C(OC)C(OC)=CC3=NC(NC4=CC=C(C=C4)OC5=CC=CC=C5)=N2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen KF, et al. Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity. Bioorg Med Chem. 2012;20(20):6144-6153. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PP2A Cancerous-IN-1

All Akt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PP2A Cancerous-IN-1 Related Classifications

HY-139296 Related Classifications