PPP4C - protein phosphatase 4 catalytic subunit Gene

Also Known as PP4; PPX; PP-X; PP4C; PPH3; PPP4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5531

About PPP4C

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,075,994-30,085,376 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 31.5), placenta (RPKM 25.7) and 25 other tissues.

Summary

Enables protein serine/threonine Phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PPP4C Products (5)

mRNA Protein Name
NM_001303503.2 NP_001290432.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 1
NM_001303504.2 NP_001290433.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 2
NM_001303506.2 NP_001290435.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 3
NM_001303507.2 NP_001290436.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 3
NM_002720.3 NP_002711.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9647778 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
18715871 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of double-strand break repair IMP
IMP: Inferred from mutant phenotype
18614045 GOA
involved in regulation of double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
20154705 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
18614045 GOA
part of protein phosphatase 4 complex IPI
IPI: Inferred from physical interaction
18614045 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP4C Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (48 - 240)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 4 catalytic subunit

  • epididymis secretory sperm binding protein

PPP4C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
16085932
Intra
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
19156129
Intra
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
18715871
Intra
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
TAP
16085932
Intra
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Bait CoIP
17353931
Intra
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
33961781
Intra
PPP4C P60510 PPP4R2 Homo sapiens Q9NY27
Anti Tag CoIP
27880917
Intra
PPP4C P60510 TIPRL Homo sapiens O75663
Anti Tag CoIP
17384681
Intra
PPP4C P60510 TIPRL Homo sapiens O75663
Anti Tag CoIP
27880917
Intra
PPP4C P60510 TIPRL Homo sapiens O75663
Anti Tag CoIP
16085932
Intra
PPP4C P60510 TIPRL Homo sapiens O75663
Anti Bait CoIP
17353931
Intra
PPP4C P60510 IGBP1 Homo sapiens P78318
Anti Tag CoIP
18715871
Intra
PPP4C P60510 IGBP1 Homo sapiens P78318
Y2H
9647778
Intra
PPP4C P60510 IGBP1 Homo sapiens P78318
Y2H Array
32296183
Intra
PPP4C P60510 IGBP1 Homo sapiens P78318
TAP
16085932
Intra
PPP4C P60510 IGBP1 Homo sapiens P78318
Anti Tag CoIP
33961781
Intra
PPP4C P60510 IGBP1 Homo sapiens P78318
Anti Tag CoIP
19156129
Intra
PPP4C P60510 IGBP1 Homo sapiens P78318
Y2H Prey Pooling
32296183
Intra
PPP4C P60510 IGBP1 Homo sapiens P78318
Anti Tag CoIP
27880917
Intra
PPP4C P60510 IGBP1 Homo sapiens P78318
Anti Bait CoIP
18614045
Intra
PPP4C P60510 IGBP1 Homo sapiens P78318
Validated Y2H
32296183
Intra
PPP4C P60510 PPP4R1 Homo sapiens Q8TF05
Anti Tag CoIP
27880917
Intra
PPP4C P60510 PPP4R1 Homo sapiens Q8TF05
Anti Tag CoIP
18715871
Intra
PPP4C P60510 PPP4R1 Homo sapiens Q8TF05
TAP
16085932
Intra
PPP4C P60510 PPP4R1 Homo sapiens Q8TF05
Anti Tag CoIP
33961781
Intra
PPP4C P60510 PPP4R1 Homo sapiens Q8TF05
Anti Bait CoIP
17353931
Intra
PPP4C P60510 PTPA Homo sapiens Q15257
Anti Tag CoIP
33961781
Intra
PPP4C P60510 PPP4R4 Homo sapiens Q6NUP7
Anti Tag CoIP
27880917
Intra
PPP4C P60510 PPP4R4 Homo sapiens Q6NUP7
Anti Tag CoIP
18715871
Intra
PPP4C P60510 PPP4R4 Homo sapiens Q6NUP7
Anti Tag CoIP
33961781
Intra
PPP4C P60510 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
33961781
Intra
PPP4C P60510 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
19156129
Intra
PPP4C P60510 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
27880917
Intra
PPP4C P60510 PPP2R1A Homo sapiens P30153
Anti Tag CoIP
18715871
Intra
PPP4C P60510 PPP2R1A Homo sapiens P30153
Anti Bait CoIP
17353931
Intra
PPP4C P60510 HDAC3 Homo sapiens O15379
Anti Tag CoIP
15805470
Intra
PPP4C P60510 HDAC3 Homo sapiens O15379
Pull Down
15805470
Cross: Cross-species interaction Intra: Intraspecies interaction

PPP4C Antibodies

Cat. No. Product Name Application Reactivity
HY-P80873 Protein Phosphatase 4C Antibody (YA687) WB, IHC-F, IHC-P, ICC/IF Human
HY-P80873A Protein Phosphatase 4C Antibody (YA687)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human
HY-P85458 Protein Phosphatase 4C Antibody (YA5150) WB, IHC-P, FC Human, Mouse, Rat
HY-P85500 Protein Phosphatase 4C Antibody (YA5192) WB, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Contagious Pustular Dermatitis

  • Ecthyma, Contagious

  • Orf

  • Ecthyma Contagiosum

  • Scabby Mouth

  • Sheep Pox

  • Thistle Disease

  • Contagious Pustular Dermatosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11028 PPP4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22739 Ppp4c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29253 Ppp4c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPP4C VGNC VGNC:69022
Mus musculus PPP4C MGD MGI:1891763
Bos taurus PPP4C VGNC VGNC:33268
Macaca mulatta PPP4C VGNC VGNC:76384
Rattus norvegicus PPP4C RGD RGD:621225
Canis familiaris PPP4C VGNC VGNC:44921
Others PPP4C NCBI