2. Gene
  3. PPP4C - protein phosphatase 4 catalytic subunit Gene

PPP4C - protein phosphatase 4 catalytic subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP4; PPX; PP-X; PP4C; PPH3; PPP4

Gene ID: 5531 | Gene type: protein coding

About PPP4C

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,075,994-30,085,376 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 31.5), placenta (RPKM 25.7) and 25 other tissues.

Summary

Enables protein serine/threonine Phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PPP4C Products(5)

mRNA Protein Name
NM_001303503.2 NP_001290432.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 1
NM_001303504.2 NP_001290433.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 2
NM_001303506.2 NP_001290435.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 3
NM_001303507.2 NP_001290436.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 3
NM_002720.3 NP_002711.1 serine/threonine-protein phosphatase 4 catalytic subunit isoform 1

PPP4C Protein Structure

Metallophos

Metallophos: Calcineurin-like phosphoesterase (48 - 240)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 4 catalytic subunit

epididymis secretory sperm binding protein

Related Diseases

Diseases Alias
Contagious Pustular Dermatitis

Ecthyma, Contagious

Orf

Ecthyma Contagiosum

Scabby Mouth

Sheep Pox

Thistle Disease

Contagious Pustular Dermatosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11028 PPP4C Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPP4C VGNC VGNC:69022
Mus musculus PPP4C MGD MGI:1891763
Bos taurus PPP4C VGNC VGNC:33268
Macaca mulatta PPP4C VGNC VGNC:76384
Rattus norvegicus PPP4C RGD RGD:621225
Canis familiaris PPP4C VGNC VGNC:44921