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IGBP1 - immunoglobulin binding protein 1 Gene

Also Known as IBP1; MRXS28; alpha4; ALPHA-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3476

About IGBP1

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,133,447-70,166,324 (from NCBI)

This gene has 2 transcripts (splice variants), 236 orthologues, 1 paralogue and is associated with 4 phenotypes. Ubiquitous expression in ovary (RPKM 49.2), thyroid (RPKM 31.5) and 25 other tissues.

Summary

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]

IGBP1 Products (4)

mRNA	Protein	Name
NM_001370192.1	NP_001357121.1	immunoglobulin-binding protein 1 isoform 1
NM_001370193.1	NP_001357122.1	immunoglobulin-binding protein 1 isoform 1
NM_001370194.1	NP_001357123.1	immunoglobulin-binding protein 1 isoform 2
NM_001551.3	NP_001542.1	immunoglobulin-binding protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9647778	GOA
enables protein phosphatase regulator activity	IDA IDA: Inferred from direct assay	9647778	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	17438131	GOA
involved in negative regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	17438131	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17438131	GOA
involved in regulation of microtubule-based movement	IMP IMP: Inferred from mutant phenotype	18949047	GOA
involved in response to interleukin-1	IMP IMP: Inferred from mutant phenotype	17438131	GOA
involved in response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	17438131	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGBP1 Protein Structure

TAP42

0
100
200
300
339 a.a.

Protein Preferred Names	Protein Names
immunoglobulin-binding protein 1	B cell signal transduction molecule alpha 4

IGBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IGBP1	P78318	PPP2CB	Homo sapiens	P62714	Anti Tag CoIP	26496610
Intra	IGBP1	P78318	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	18715871
Intra	IGBP1	P78318	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	16769727
Intra	IGBP1	P78318	PPP4C	Homo sapiens	P60510	TAP	16085932
Intra	IGBP1	P78318	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	26496610
Intra	IGBP1	P78318	TIPRL	Homo sapiens	O75663	Anti Bait CoIP	23892082
Intra	IGBP1	P78318	MID1	Homo sapiens	O15344	Anti Tag CoIP	26496610
Intra	IGBP1	P78318	HSPB1	Homo sapiens	P04792	Reverse RRS	25277244
Intra	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	18186651
Intra	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Y2H	9647778
Intra	IGBP1	P78318	PPP6C	Homo sapiens	O00743	TAP	16085932
Intra	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	26496610
Intra	IGBP1	P78318	PPP6C	Homo sapiens	O00743	Pull Down	9647778
Intra	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	9647778
Intra	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	26496610
Intra	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	TAP	16085932
Intra	IGBP1	P78318	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Corpus Callosum, Agenesis Of, With Impaired Intellectual Development, Ocular Coloboma, And Micrognathia	MRXS28 Mental Retardation, X-Linked, Syndromic 28 Intellectual Development Disorder, X-Linked, Syndromic 28 Corpus Callosum, Agenesis Of, With Impaired Intellectual Development, Ocular Coloboma And Micrognathia Intellectual Developmental Disorder, X-Linked, Syndromic 28 Agenesis Of The Corpus Callosum With Impaired Intellectual Development, Ocular Coloboma And Micrognathia
Corpus Callosum Agenesis-Intellectual Disability-Coloboma-Micrognathia Syndrome	Graham-Cox Syndrome Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma And Micrognathia Mental Retardation, X-Linked, Syndromic 28 Mrxs28 Agenesis Of The Corpus Callosum-Intellectual Disability-Coloboma-Micrognathia Syndrome Agenesis, Corpus Callosum, With Mental Retardation, Ocular Coloboma And Micrognathia Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia
Barbiturate Abuse
Progressive Multifocal Leukoencephalopathy	Pml Leukoencephalopathy, Progressive Multifocal Progressive Multifocal Leukoencephalitis Leukoencephalopathy Progressive Multifocal Pml - [Progressive Multifocal Leukoencephalopathy]
Autosomal Dominant Alport Syndrome	Alport Syndrome, Autosomal Dominant Alport Syndrome Dominant Type Renal Failure And Sensorineural Hearing Loss Alport Syndrome, Dominant Type
Autosomal Recessive Alport Syndrome	Alport Syndrome, Recessive Type Alport Syndrome, Autosomal Recessive Alport Syndrome Autosomal Recessive Alport Syndrome Recessive Type Nephropathy And Deafness
Hemoglobin H Disease	HBH Hemoglobin H Disease, Nondeletional Hemoglobin H Disease, Deletional Alpha-Thalassemia Intermedia Haemoglobin H Disease Alpha-Thalassemia, Hemoglobin H Type Hemoglobin H Disease, Deletional And Nondeletional Alpha Thalassemia, Haemoglobin H Type Alpha Thalassemia, Hemoglobin H Type Haemoglobin H Disease, Deletional Hbh Disease Alpha-Thalassemia Hemoglobin H Type Hemoglobin H Disease Deletional Hemoglobin H Disease Non-Deletional Alpha-Thalassemia Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia Alpha Thalassaemia Intermedia
Hypoalphalipoproteinemia, Primary, 2	Apolipoprotein A-I Deficiency Hypoalphalipoproteinemia, Primary, 2, Autosomal Recessive Primary Hypoalphalipoproteinemia 2 High Density Lipoprotein Deficiency Apoa-I Deficiency Familial Apoa-I Deficiency Familial Hypoalphalipoproteinemia FHA2 Apolipoprotein A-I
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy	Adnfle Autosomal Dominant Sleep-Related Hypermotor Epilepsy Enfl Benign Familial Infantile Seizures 6 Benign Familial Infantile Seizures, 6 Nocturnal Frontal Lobe Epilepsy-4 Enfl1 Epilepsy, Nocturnal Frontal Lobe, 1 Epilepsy, Nocturnal Frontal Lobe, Type 1
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06612	IGBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IGBP1	VGNC	VGNC:54166
Rattus norvegicus	IGBP1	RGD	RGD:62011
Mus musculus	IGBP1	MGD	MGI:1346500
Others	IGBP1	NCBI