TIPRL - TOR signaling pathway regulator Gene

Also Known as TIP; TIP41; TIPRL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 261726

About TIPRL

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,178,962-168,202,109 (from NCBI)

This gene has 2 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in endometrium (RPKM 11.7), brain (RPKM 11.6) and 25 other tissues.

Summary

TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

TIPRL Products (2)

mRNA Protein Name
NM_001031800.3 NP_001026970.1 TIP41-like protein isoform 2
NM_152902.5 NP_690866.1 TIP41-like protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16085932 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
17384681 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIPRL Protein Structure

TIP41

TIP41: TIP41-like family (48 - 225)

  • 0
  • 100
  • 200
  • 272 a.a.
Protein Preferred Names Protein Names

TIP41-like protein

  • TIP41, TOR signaling pathway regulator-like

TIPRL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TIPRL O75663 PPP2CB Homo sapiens P62714
Anti Tag CoIP
16085932
Intra
TIPRL O75663 PPP4C Homo sapiens P60510
Anti Bait CoIP
18614045
Intra
TIPRL O75663 PPP4C Homo sapiens P60510
TAP
16085932
Intra
TIPRL O75663 IGBP1 Homo sapiens P78318
Anti Bait CoIP
23892082
Intra
TIPRL O75663 PPP6C Homo sapiens O00743
Anti Tag CoIP
17384681
Intra
TIPRL O75663 PPP2CA Homo sapiens P67775
Anti Tag CoIP
17384681
Intra
TIPRL O75663 PPP2CA Homo sapiens P67775
Anti Bait CoIP
23892082
Cross
TIPRL O75663 Ppp2ca Rattus norvegicus P63331
Anti Tag CoIP
23892082
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alzheimer Disease 15

  • AD15

  • Alzheimer'S Disease 15

  • Alzheimer Disease Without Neurofibrillary Tangles

  • Alzheimer'S Disease 15, Late Onset

  • Alzheimer'S Disease Without Neurofibrillary Tangles
Cardiomyopathy, Dilated, 1e

  • Left Ventricular Noncompaction 9

  • Left Ventricular Noncompaction 5

  • Dilated Cardiomyopathy 1e

  • Dilated Cardiomyopathy 1s

  • CMD1E

  • Cdcd2

  • Cardiomyopathy, Dilated, 1y

  • CMD1Y

  • Cardiomyopathy, Dilated, 1s

  • CMD1S

  • Dilated Cardiomyopathy 1y

  • Dilated Cardiomyopathy With Conduction Defect 2

  • Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia

  • Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia

  • Cardiomyopathy, Dilated, With Conduction Defect 2

  • Cardiomyopathy Dilated With Conduction Defect Type 2

  • Cardiomyopathy, Dilated 1e

  • Cardiomyopathy, Dilated 1s

  • Cardiomyopathy, Dilated 1y

  • Left Ventricular Non-Compaction 5

  • LVNC5

  • Left Ventricular Non-Compaction 9

  • LVNC9

  • Cardiomyopathy, Dilated, Type 1e

  • Cardiomyopathy, Dilated, Type 1s

  • Cardiomyopathy, Dilated, Type 1y
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14550 TIPRL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20500 Tiprl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27008 Tiprl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TIPRL MGD MGI:1915087
Macaca mulatta TIPRL VGNC VGNC:79838
Canis familiaris TIPRL VGNC VGNC:47383
Rattus norvegicus TIPRL RGD RGD:1310442
Felis catus TIPRL VGNC VGNC:107949
Bos taurus TIPRL VGNC VGNC:35878
Others TIPRL NCBI