TIPRL - TOR signaling pathway regulator Gene

Homo sapiens

Also known as TIP; TIP41; TIPRL1

Gene ID: 261726 | Gene type: protein coding

About TIPRL

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,178,962-168,202,109 (from NCBI)

This gene has 2 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in endometrium (RPKM 11.7), brain (RPKM 11.6) and 25 other tissues.

Summary

TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]

TIPRL Products(2)

mRNA	Protein	Name
NM_001031800.3	NP_001026970.1	TIP41-like protein isoform 2
NM_152902.5	NP_690866.1	TIP41-like protein isoform 1

TIPRL Protein Structure

TIP41

0
100
200
272 a.a.

Protein Preferred Names

Protein Names

TIP41-like protein

TIP41, TOR signaling pathway regulator-like

Related Diseases

Diseases

Alias

Alzheimer Disease 15

AD15	Alzheimer'S Disease 15
Alzheimer Disease Without Neurofibrillary Tangles	Alzheimer'S Disease 15, Late Onset
Alzheimer'S Disease Without Neurofibrillary Tangles

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9	Left Ventricular Noncompaction 5
Dilated Cardiomyopathy 1e	Dilated Cardiomyopathy 1s
CMD1E	Cdcd2
Cardiomyopathy, Dilated, 1y	CMD1Y
Cardiomyopathy, Dilated, 1s	CMD1S
Dilated Cardiomyopathy 1y	Dilated Cardiomyopathy With Conduction Defect 2
Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia	Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia
Cardiomyopathy, Dilated, With Conduction Defect 2	Cardiomyopathy Dilated With Conduction Defect Type 2
Cardiomyopathy, Dilated 1e	Cardiomyopathy, Dilated 1s
Cardiomyopathy, Dilated 1y	Left Ventricular Non-Compaction 5
LVNC5	Left Ventricular Non-Compaction 9
LVNC9	Cardiomyopathy, Dilated, Type 1e
Cardiomyopathy, Dilated, Type 1s	Cardiomyopathy, Dilated, Type 1y

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14550	TIPRL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TIPRL	MGD	MGI:1915087
Macaca mulatta	TIPRL	VGNC	VGNC:79838
Canis familiaris	TIPRL	VGNC	VGNC:47383
Rattus norvegicus	TIPRL	RGD	RGD:1310442
Felis catus	TIPRL	VGNC	VGNC:107949
Bos taurus	TIPRL	VGNC	VGNC:35878

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