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PPP6C - protein phosphatase 6 catalytic subunit Gene

Also Known as PP6; PP6C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5537

About PPP6C

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:125,146,573-125,189,803 (from NCBI)

This gene has 4 transcripts (splice variants), 220 orthologues, 12 paralogues and is associated with 71 phenotypes. Ubiquitous expression in thyroid (RPKM 20.0), fat (RPKM 18.6) and 25 other tissues.

Summary

This gene encodes the catalytic subunit of protein Phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]

PPP6C Products (3)

mRNA	Protein	Name
NM_001123355.2	NP_001116827.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform a
NM_001123369.2	NP_001116841.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform c
NM_002721.5	NP_002712.1	serine/threonine-protein phosphatase 6 catalytic subunit isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9647778	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	32474700	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	32474700	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP6C Protein Structure

Metallophos

0
100
200
305 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 6 catalytic subunit	serine/threonine protein phosphatase catalytic subunit

PPP6C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP6C	O00743	TIPRL	Homo sapiens	O75663	Anti Tag CoIP	16085932
Intra	PPP6C	O00743	TIPRL	Homo sapiens	O75663	Anti Tag CoIP	24255178
Intra	PPP6C	O00743	IGBP1	Homo sapiens	P78318	Y2H Prey Pooling	32296183
Intra	PPP6C	O00743	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	33961781
Intra	PPP6C	O00743	IGBP1	Homo sapiens	P78318	Y2H	9647778
Intra	PPP6C	O00743	IGBP1	Homo sapiens	P78318	Validated Y2H	32296183
Intra	PPP6C	O00743	IGBP1	Homo sapiens	P78318	Y2H Array	32296183
Intra	PPP6C	O00743	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	24255178
Intra	PPP6C	O00743	IGBP1	Homo sapiens	P78318	Pull Down	28330616
Intra	PPP6C	O00743	IGBP1	Homo sapiens	P78318	Anti Tag CoIP	9647778
Intra	PPP6C	O00743	VAC14	Homo sapiens	Q08AM6	Validated Y2H	32296183
Intra	PPP6C	O00743	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	PPP6C	O00743	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	PPP6C	O00743	PPP6R3	Homo sapiens	Q5H9R7	Pull Down	28330616
Intra	PPP6C	O00743	PPP6R3	Homo sapiens	Q5H9R7	Anti Tag CoIP	21187329
Intra	PPP6C	O00743	PPP6R3	Homo sapiens	Q5H9R7	Anti Tag CoIP	33961781
Intra	PPP6C	O00743	PPP6R3	Homo sapiens	Q5H9R7	Anti Tag CoIP	24255178
Intra	PPP6C	O00743	MAP3K7	Homo sapiens	O43318	Anti Bait CoIP	17079228
Intra	PPP6C	O00743	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	33961781
Intra	PPP6C	O00743	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	21187329
Intra	PPP6C	O00743	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	24255178
Intra	PPP6C	O00743	ANKRD28	Homo sapiens	O15084	Pull Down	28330616
Intra	PPP6C	O00743	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	18186651
Intra	PPP6C	O00743	PPP6R2	Homo sapiens	O75170	Anti Tag CoIP	18186651
Intra	PPP6C	O00743	PPP6R2	Homo sapiens	O75170	Pull Down	28330616
Intra	PPP6C	O00743	PPP6R2	Homo sapiens	O75170	Anti Tag CoIP	16769727
Intra	PPP6C	O00743	PPP6R2	Homo sapiens	O75170	Anti Tag CoIP	24255178
Intra	PPP6C	O00743	PPP6R2	Homo sapiens	O75170	Anti Tag CoIP	21187329
Intra	PPP6C	O00743	PPP6R2	Homo sapiens	O75170	Anti Tag CoIP	33961781
Intra	PPP6C	O00743	PPP6R1	Homo sapiens	Q9UPN7	Anti Tag CoIP	18186651
Intra	PPP6C	O00743	PPP6R1	Homo sapiens	Q9UPN7	Pull Down	28330616
Intra	PPP6C	O00743	PPP6R1	Homo sapiens	Q9UPN7	Anti Tag CoIP	16769727
Intra	PPP6C	O00743	PPP6R1	Homo sapiens	Q9UPN7	Anti Tag CoIP	24255178
Intra	PPP6C	O00743	PPP6R1	Homo sapiens	Q9UPN7	Anti Tag CoIP	21187329
Intra	PPP6C	O00743	PPP6R1	Homo sapiens	Q9UPN7	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Skin Melanoma	Cutaneous Melanoma Malignant Ear Melanoma Malignant Lip Melanoma Malignant Lower Limb Melanoma Malignant Melanoma Of Ear And/Or External Auricular Canal Malignant Melanoma Of Skin Of Lower Limb Malignant Melanoma Of Skin Of Trunk Except Scrotum Malignant Melanoma Of Skin Of Upper Limb Malignant Neck Melanoma Malignant Scalp Melanoma Malignant Trunk Melanoma Malignant Upper Limb Melanoma Melanoma, Cutaneous Malignant Melanoma Malignant Melanoma Of Skin Melanoma Nos Malignant Mole, Meaning Melanoma Of Unspecified Site Melanoma Of Unspecified Site Cutaneous Malignant Melanoma Mm - [Malignant Melanoma]
Lung Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lung Squamous Cell Lung Carcinoma Epidermoid Cell Carcinoma Of The Lung Squamous Cell Lung Cancer
Pineal Parenchymal Tumor Of Intermediate Differentiation	Pineal Parenchymal Tumour Of Intermediate Differentiation Pineal Parenchymal Tumors Of Intermediate Differentiation Pptid
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Melanoma, Cutaneous Malignant 1	Familial Melanoma Melanoma, Cutaneous Malignant, Susceptibility To, 1 Melanoma, Malignant CMM1 Melanoma, Cutaneous Malignant Cmm Familial Atypical Mole-Malignant Melanoma Syndrome Fammm Melanoma, Familial Mlm Dysplastic Nevus Syndrome, Hereditary Dns B-K Mole Syndrome Melanoma, Cutaneous Malignant, 1 Malignant Melanoma, Cutaneous Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1 Dysplastic Nevus Syndrome Cutaneous Melanoma Familial Atypical Mole Melanoma Syndrome Hereditary Melanoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11033	PPP6C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19473	Ppp6c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25966	Ppp6c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PPP6C	VGNC	VGNC:102969
Mus musculus	PPP6C	MGD	MGI:1915107
Canis familiaris	PPP6C	VGNC	VGNC:49946
Macaca mulatta	PPP6C	VGNC	VGNC:101481
Bos taurus	PPP6C	VGNC	VGNC:33273
Rattus norvegicus	PPP6C	RGD	RGD:708460
Others	PPP6C	NCBI