PPP6R3 - protein phosphatase 6 regulatory subunit 3 Gene
Also Known as SAPL; PP6R3; SAPLa; SAPS3; SAP190; C11orf23
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 55291
About PPP6R3
Cytogenetic location: 11q13.2
Genomic coordinates (GRCh38): 11:68,460,752-68,615,334 (from NCBI)
This gene has 26 transcripts (splice variants), 218 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 14.0), testis (RPKM 11.4) and 25 other tissues.
Summary
Protein Phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein Phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
PPP6R3 Products (39)
| mRNA | Protein | Name |
|---|---|---|
| NM_001164160.2 | NP_001157632.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4 |
| NM_001164161.2 | NP_001157633.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6 |
| NM_001164162.2 | NP_001157634.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 1 |
| NM_001164163.2 | NP_001157635.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2 |
| NM_001164164.2 | NP_001157636.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 3 |
| NM_001352347.2 | NP_001339276.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 7 |
| NM_001352348.2 | NP_001339277.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 1 |
| NM_001352350.2 | NP_001339279.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8 |
| NM_001352351.2 | NP_001339280.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 9 |
| NM_001352352.2 | NP_001339281.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 10 |
| NM_001352353.2 | NP_001339282.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 11 |
| NM_001352354.2 | NP_001339283.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 12 |
| NM_001352355.2 | NP_001339284.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 13 |
| NM_001352356.2 | NP_001339285.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 12 |
| NM_001352357.2 | NP_001339286.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 14 |
| NM_001352358.2 | NP_001339287.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 15 |
| NM_001352359.2 | NP_001339288.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 16 |
| NM_001352360.2 | NP_001339289.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 17 |
| NM_001352361.2 | NP_001339290.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 18 |
| NM_001352362.2 | NP_001339291.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 19 |
| NM_001352363.2 | NP_001339292.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 2 |
| NM_001352364.2 | NP_001339293.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4 |
| NM_001352365.2 | NP_001339294.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 19 |
| NM_001352366.2 | NP_001339295.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 23 |
| NM_001352368.2 | NP_001339297.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6 |
| NM_001352369.2 | NP_001339298.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 20 |
| NM_001352370.2 | NP_001339299.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 21 |
| NM_001352371.2 | NP_001339300.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 10 |
| NM_001352372.2 | NP_001339301.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 24 |
| NM_001352373.2 | NP_001339302.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 17 |
| NM_001352374.2 | NP_001339303.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 22 |
| NM_001352375.2 | NP_001339304.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 6 |
| NM_001352376.2 | NP_001339305.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8 |
| NM_001352377.2 | NP_001339306.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 24 |
| NM_001352378.2 | NP_001339307.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 22 |
| NM_001352379.2 | NP_001339308.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 4 |
| NM_001352380.2 | NP_001339309.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 8 |
| NM_001411030.1 | NP_001397959.1 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 25 |
| NM_018312.5 | NP_060782.2 | serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform 5 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
18186651 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
PPP6R3 Protein Structure
SAPS
SAPS: SIT4 phosphatase-associated protein (129 - 361)
SAPS
SAPS: SIT4 phosphatase-associated protein (363 - 512)
- 0
- 200
- 400
- 600
- 800
- 873 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serine/threonine-protein phosphatase 6 regulatory subunit 3 |
|
PPP6R3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PPP6R3 | Q5H9R7 | ANKRD28 | Homo sapiens | O15084 | 18186651 | |
|
Intra
|
PPP6R3 | Q5H9R7 | PPP6C | Homo sapiens | O00743 | 18186651 | |
|
Intra
|
PPP6R3 | Q5H9R7 | TERF2IP | Homo sapiens | Q9NYB0 | 21044950 | |
|
Intra
|
PPP6R3 | Q5H9R7 | TERF2IP | Homo sapiens | Q9NYB0 | 21044950 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Fasciitis |
|
|
| Acute Cor Pulmonale |
|
|
| Acute Pulmonary Heart Disease |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS11036 | PPP6R3 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | PPP6R3 | VGNC | VGNC:44927 |
| Rattus norvegicus | PPP6R3 | RGD | RGD:1307145 |
| Felis catus | PPP6R3 | VGNC | VGNC:64334 |
| Bos taurus | PPP6R3 | VGNC | VGNC:33275 |
| Macaca mulatta | PPP6R3 | VGNC | VGNC:76246 |
| Mus musculus | PPP6R3 | MGD | MGI:1921807 |
| Others | PPP6R3 | NCBI |
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