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PPP6R1 - protein phosphatase 6 regulatory subunit 1 Gene

Also Known as PP6R1; SAPS1; SAP190; KIAA1115

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22870

About PPP6R1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,228,218-55,259,017 (from NCBI)

This gene has 8 transcripts (splice variants), 119 orthologues and 2 paralogues. Broad expression in testis (RPKM 56.4), lymph node (RPKM 37.5) and 24 other tissues.

Summary

Protein Phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein Phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

PPP6R1 Products (1)

mRNA	Protein	Name
NM_014931.4	NP_055746.3	serine/threonine-protein phosphatase 6 regulatory subunit 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	25743393	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP6R1 Protein Structure

SAPS

0
200
400
600
800
881 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 6 regulatory subunit 1	SAPS domain family, member 1

PPP6R1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP6R1	Q9UPN7	ANKRD44	Homo sapiens	Q8N8A2	Anti Tag CoIP	18186651
Intra	PPP6R1	Q9UPN7	ANKRD44	Homo sapiens	Q8N8A2	BioID	24255178
Intra	PPP6R1	Q9UPN7	ANKRD44	Homo sapiens	Q8N8A2	Anti Tag CoIP	35271311
Intra	PPP6R1	Q9UPN7	ANKRD44	Homo sapiens	Q8N8A2	Anti Tag CoIP	24255178
Intra	PPP6R1	Q9UPN7	ANKRD52	Homo sapiens	Q8NB46	BioID	24255178
Intra	PPP6R1	Q9UPN7	ANKRD52	Homo sapiens	Q8NB46	Anti Tag CoIP	35271311
Intra	PPP6R1	Q9UPN7	ANKRD52	Homo sapiens	Q8NB46	Anti Tag CoIP	24255178
Intra	PPP6R1	Q9UPN7	NFKBIE	Homo sapiens	O00221	Anti Tag CoIP	16769727
Intra	PPP6R1	Q9UPN7	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	18186651
Intra	PPP6R1	Q9UPN7	ANKRD28	Homo sapiens	O15084	BioID	24255178
Intra	PPP6R1	Q9UPN7	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	35271311
Intra	PPP6R1	Q9UPN7	ANKRD28	Homo sapiens	O15084	Anti Tag CoIP	24255178
Intra	PPP6R1	Q9UPN7	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	24255178
Intra	PPP6R1	Q9UPN7	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	18186651
Intra	PPP6R1	Q9UPN7	PPP6C	Homo sapiens	O00743	Chromatography	18186651
Intra	PPP6R1	Q9UPN7	PPP6C	Homo sapiens	O00743	BioID	24255178
Intra	PPP6R1	Q9UPN7	PPP6C	Homo sapiens	O00743	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Median Rhomboid Glossitis	Persistent Tuberculum Impar Glossitis Rhomboidea Mediana Superficial Midline Glossitis
Denture Stomatitis	Stomatitis, Denture Denture Sore Mouth
Amyotrophic Lateral Sclerosis Type 12	Amyotrophic Lateral Sclerosis 12 Als12 Sclerosis, Lateral, Amyotrophic, Type Type 12
Melancholia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11034	PPP6R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPP6R1	MGD	MGI:2442163
Felis catus	PPP6R1	VGNC	VGNC:64332
Bos taurus	PPP6R1	VGNC	VGNC:52234
Macaca mulatta	PPP6R1	VGNC	VGNC:76341
Rattus norvegicus	PPP6R1	RGD	RGD:1311409
Canis familiaris	PPP6R1	VGNC	VGNC:44925
Others	PPP6R1	NCBI