2. Gene
  3. NFKBIE - NFKB inhibitor epsilon Gene

NFKBIE - NFKB inhibitor epsilon Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IKBE

Gene ID: 4794 | Gene type: protein coding

About NFKBIE

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,258,166-44,265,551 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues, 16 paralogues and is associated with 54 phenotypes. Broad expression in bone marrow (RPKM 9.4), spleen (RPKM 9.3) and 25 other tissues.

Summary

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]

NFKBIE Products(1)

mRNA Protein Name
NM_004556.3 NP_004547.3 NF-kappa-B inhibitor epsilon

NFKBIE Protein Structure

Ank_2

Ank_2: Ankyrin repeats (3 copies) (286 - 353)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (374 - 467)

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  • 500 a.a.
Protein Preferred Names Protein Names

NF-kappa-B inhibitor epsilon

I-kappa-B-epsilon

Related Diseases

Diseases Alias
St2 Diffuse Large B-Cell Lymphoma

St2 Dlbcl

Doid:0081068
Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum

Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09263 NFKBIE Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NFKBIE MGD MGI:1194908
Bos taurus NFKBIE VGNC VGNC:32048
Felis catus NFKBIE VGNC VGNC:68485
Rattus norvegicus NFKBIE RGD RGD:735070
Macaca mulatta NFKBIE VGNC VGNC:75342
Others NFKBIE NCBI