PPP6R2 - protein phosphatase 6 regulatory subunit 2 Gene

Also Known as PP6R2; SAPS2; SAP190; KIAA0685

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9701

About PPP6R2

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,330,774-50,445,090 (from NCBI)

This gene has 9 transcripts (splice variants), 285 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 24.1), brain (RPKM 12.1) and 25 other tissues.

Summary

The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop Phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]

PPP6R2 Products (13)

mRNA Protein Name
NM_001242898.2 NP_001229827.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1
NM_001242899.2 NP_001229828.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 2
NM_001242900.2 NP_001229829.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 4
NM_001351641.2 NP_001338570.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 5
NM_001351642.2 NP_001338571.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 6
NM_001351643.2 NP_001338572.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 1
NM_001351644.2 NP_001338573.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 7
NM_001351645.2 NP_001338574.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3
NM_001351646.2 NP_001338575.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 8
NM_001351647.2 NP_001338576.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 9
NM_001351648.2 NP_001338577.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 10
NM_001365836.1 NP_001352765.1 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 11
NM_014678.5 NP_055493.2 serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14743216 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP6R2 Protein Structure

SAPS

SAPS: SIT4 phosphatase-associated protein (129 - 360)

SAPS

SAPS: SIT4 phosphatase-associated protein (361 - 531)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 966 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 6 regulatory subunit 2

  • SAPS domain family, member 2

PPP6R2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP6R2 O75170 ANKRD28 Homo sapiens O15084
Anti Tag CoIP
33961781
Intra
PPP6R2 O75170 ANKRD28 Homo sapiens O15084
Anti Tag CoIP
24255178
Intra
PPP6R2 O75170 ANKRD28 Homo sapiens O15084
BioID
24255178
Intra
PPP6R2 O75170 ANKRD28 Homo sapiens O15084
Anti Tag CoIP
18186651
Intra
PPP6R2 O75170 PPP6C Homo sapiens O00743
BioID
24255178
Intra
PPP6R2 O75170 PPP6C Homo sapiens O00743
Anti Tag CoIP
24255178
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease, Type 4b3

  • Charcot-Marie-Tooth Disease Type 4b3

  • CMT4B3

  • Charcot-Marie-Tooth Disease With Focally Folded Myelin

  • Charcot-Marie-Tooth Disease 4b3

  • Charcot-Marie-Tooth Neuropathy Type 4b3
Acute Cor Pulmonale
Acute Pulmonary Heart Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11035 PPP6R2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21175 Ppp6r2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27692 Ppp6r2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PPP6R2 VGNC VGNC:33274
Macaca mulatta PPP6R2 VGNC VGNC:76288
Rattus norvegicus PPP6R2 RGD RGD:1563990
Mus musculus PPP6R2 MGD MGI:1918724
Felis catus PPP6R2 VGNC VGNC:64333
Canis familiaris PPP6R2 VGNC VGNC:44926
Others PPP6R2 NCBI