PPP2CA - Ppp2ca protein phosphatase 2 catalytic subunit alpha Gene

Also Known as Pp2a1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24672

Summary

Enables several functions, including beta-2 Adrenergic Receptor binding activity; enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of transport; and regulation of cellular protein metabolic process. Acts upstream of or within regulation of protein autophosphorylation; regulation of protein catabolic process; and regulation of signaling receptor activity. Located in cytosol; postsynaptic density; and terminal bouton. Part of protein Phosphatase type 2A complex. Biomarker of type 2 diabetes mellitus. Orthologous to human PPP2CA (protein Phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

PPP2CA Products (1)

mRNA Protein Name
NM_017039.2 NP_058735.1 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-2 adrenergic receptor binding IPI
IPI: Inferred from physical interaction
20395454 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
18031790 RGD
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
19029245 RGD
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
15728831 RGD
enables protein antigen binding IPI
IPI: Inferred from physical interaction
8065321 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10984483 RGD
enables protein domain specific binding IDA
IDA: Inferred from direct assay
11884620 RGD
enables protein kinase B binding IPI
IPI: Inferred from physical interaction
11884620 RGD
enables protein kinase binding IDA
IDA: Inferred from direct assay
18832448 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16899564 RGD
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
11884620 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
11032905 RGD
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
17897622 RGD
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
16519540 RGD
enables protein serine/threonine phosphatase activity IMP
IMP: Inferred from mutant phenotype
10640627 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
11032905 RGD
enables tau protein binding IPI
IPI: Inferred from physical interaction
11032905 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
10984483 RGD
Biological Process GO Annotation Evidence References Source
involved in cardiac ventricle development IEP
IEP: Inferred from expression pattern
10861850 RGD
involved in cellular response to calcium ion IEP
IEP: Inferred from expression pattern
18322138 RGD
involved in cellular response to cytokine stimulus IEP
IEP: Inferred from expression pattern
14567976 RGD
involved in cellular response to ethanol IEP
IEP: Inferred from expression pattern
20224005 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
18372231 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
22509362 RGD
involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
24265448 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
11884620 RGD
involved in cellular response to steroid hormone stimulus IEP
IEP: Inferred from expression pattern
18079279 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
9432115 RGD
involved in negative regulation of calcium ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
15728831 RGD
involved in negative regulation of protein import into nucleus IMP
IMP: Inferred from mutant phenotype
18322138 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
18832448 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18322138 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18322138 RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
18322138 RGD
involved in positive regulation of dephosphorylation IMP
IMP: Inferred from mutant phenotype
16884689 RGD
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
16519540 RGD
acts upstream of or within regulation of protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
19029245 RGD
acts upstream of or within regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
19029245 RGD
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19029245 RGD
acts upstream of or within regulation of signaling receptor activity IMP
IMP: Inferred from mutant phenotype
19029245 RGD
involved in response to lead ion IDA
IDA: Inferred from direct assay
22387731 RGD
Cellular Component GO Annotation Evidence References Source
part of protein phosphatase type 2A complex IMP
IMP: Inferred from mutant phenotype
19029245 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
15728831 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

  • PP2A-alpha

  • protein phosphatase 2, catalytic subunit, alpha isozyme

  • protein phosphatase-2A-alpha

PPP2CA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Ppp2ca P63331 TIPRL Homo sapiens O75663
Anti Tag CoIP
23892082
Intra
Ppp2ca P63331 Dpysl2 Rattus norvegicus P47942
Anti Bait CoIP
20220019
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11007 PPP2CA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21174 Ppp2ca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27691 Ppp2ca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PPP2CA NCBI NCBI:5515