PTPA - protein phosphatase 2 phosphatase activator Gene

Also Known as PP2A; PR53; PPP2R4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5524

About PTPA

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:129,110,950-129,148,946 (from NCBI)

This gene has 24 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in testis (RPKM 35.1), brain (RPKM 26.2) and 25 other tissues.

Summary

Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein Phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl Phosphatase activator of the dimeric form of protein Phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PTPA Products (6)

mRNA	Protein	Name
NM_001193397.2	NP_001180326.1	serine/threonine-protein phosphatase 2A activator isoform e
NM_001271832.2	NP_001258761.1	serine/threonine-protein phosphatase 2A activator isoform f
NM_021131.5	NP_066954.2	serine/threonine-protein phosphatase 2A activator isoform b
NM_178000.3	NP_821067.1	serine/threonine-protein phosphatase 2A activator isoform b
NM_178001.3	NP_821068.1	serine/threonine-protein phosphatase 2A activator isoform a
NM_178003.3	NP_821070.1	serine/threonine-protein phosphatase 2A activator isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16916641	GOA
enables phosphatase binding	IDA IDA: Inferred from direct assay	16916641	GOA
contributes to phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	16916641	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16916641	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	16916641	GOA
enables protein phosphatase regulator activity	IDA IDA: Inferred from direct assay	16916641	GOA
enables protein tyrosine phosphatase activator activity	IDA IDA: Inferred from direct assay	16916641	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	10830164	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	17333320	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ATPase complex	IDA IDA: Inferred from direct assay	16916641	GOA
part of calcium channel complex	IDA IDA: Inferred from direct assay	10830164	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17333320	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17333320	GOA
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	10318862	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPA Protein Structure

PTPA

0
100
200
300
358 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 2A activator	PP2A phosphatase activator

PTPA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPA	Q15257	PPP4C	Homo sapiens	P60510	Anti Tag CoIP	33961781
Intra	PTPA	Q15257	PPP4R2	Homo sapiens	Q9NY27	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Acute Biphenotypic Leukemia	Mixed Phenotype Acute Leukemia Acute Leukemia Of Ambiguous Lineage Acute Undifferentiated Leukemia Acute Leukemia Of Indeterminate Lineage Hybrid Acute Leukemia Mixed Lineage Acute Leukemia All With Myeloid Markers Aml With Lymphoid Markers Acute Leukemia Of Undetermined Lineage Bal Biphenotypic Acute Leukemia Undifferentiated Acute Leukemia Mpal Acute Myeloid Leukemia, Minimal Differentiation, Fab M0 Leukemia, Biphenotypic, Acute
Chromosome 13q14 Deletion Syndrome	Chromosome 13q Deletion Syndrome Deletion 13q14 Chromosome 13q Deletion 13q Deletion 13q Monosomy Deletion 13q Monosomy 13q Monosomy 13q14 Del(13)(Q14)
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109589A	trans-11-Eicosenoic acid	Inhibitor	99.95%	Unkown
HY-P11219	TAT-PDHPS1	Inhibitor	98.35%	Unkown
HY-D3430	PTPA-QM	Substrate	/	Unkown
HY-RS11412	PTPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11432	PTPRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-158570	(2E)-Eicosenoic acid	Inhibitor	/	Unkown
HY-RS18968	Ptpa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19478	Ptpra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25458	Ptpa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PTPA	VGNC	VGNC:76583
Canis familiaris	PTPA	VGNC	VGNC:45164
Felis catus	PTPA	VGNC	VGNC:97576
Bos taurus	PTPA	VGNC	VGNC:33526
Mus musculus	PTPA	MGD	MGI:1346006
Rattus norvegicus	PTPA	RGD	RGD:1308354
Others	PTPA	NCBI