PPP4R2 - protein phosphatase 4 regulatory subunit 2 Gene

Homo sapiens

Also known as PP4R2

Gene ID: 151987 | Gene type: protein coding

About PPP4R2

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:72,996,743-73,069,198 (from NCBI)

This gene has 7 transcripts (splice variants) and 93 orthologues. Ubiquitous expression in bone marrow (RPKM 21.8), testis (RPKM 13.7) and 25 other tissues.

Summary

The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein Phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

PPP4R2 Products(5)

mRNA	Protein	Name
NM_001318025.2	NP_001304954.1	serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 2
NM_001318026.2	NP_001304955.1	serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 3
NM_001318027.2	NP_001304956.1	serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 4
NM_001318028.2	NP_001304957.1	serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 5
NM_174907.4	NP_777567.1	serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 1

PPP4R2 Protein Structure

PPP4R2

0
100
200
300
361 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 4 regulatory subunit 2

Related Diseases

Diseases

Alias

Basal Cell Carcinoma, Infundibulocystic

Basal Cell Carcinoma With Follicular Differentiation	Infundibulocystic Basal Cell Carcinoma
Skin Infundibulocystic Basal Cell Carcinoma

Eccrine Papillary Adenocarcinoma

Digital Papillary Adenocarcinoma	Sweat Gland Adenocarcinoma
Digital Papillary Eccrine Carcinoma Of Skin

Malignant Acrospiroma

Eccrine Ductal Carcinoma	Hidradenocarcinoma
Anaplastic Syringoma	Eccrine Ductal Carcinoma Of Skin
Clear Cell Eccrine Carcinoma	Malignant Clear Cell Acrospiroma
Malignant Nodular/Clear Cell Hidradenoma	Primary Mucoepidermoid Cutaneous Carcinoma
Sweat Gland Adenocarcinoma

Eccrine Adenocarcinoma

Ulceroglandular Tularemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11030	PPP4R2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PPP4R2	VGNC	VGNC:110347
Rattus norvegicus	PPP4R2	RGD	RGD:1307312
Canis familiaris	PPP4R2	VGNC	VGNC:44922
Bos taurus	PPP4R2	VGNC	VGNC:33270
Mus musculus	PPP4R2	MGD	MGI:3027896
Felis catus	PPP4R2	VGNC	VGNC:64328

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