PPP4R2 - protein phosphatase 4 regulatory subunit 2 Gene

Also Known as PP4R2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 151987

About PPP4R2

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:72,996,743-73,069,198 (from NCBI)

This gene has 7 transcripts (splice variants) and 93 orthologues. Ubiquitous expression in bone marrow (RPKM 21.8), testis (RPKM 13.7) and 25 other tissues.

Summary

The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein Phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

PPP4R2 Products (5)

mRNA Protein Name
NM_001318025.2 NP_001304954.1 serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 2
NM_001318026.2 NP_001304955.1 serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 3
NM_001318027.2 NP_001304956.1 serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 4
NM_001318028.2 NP_001304957.1 serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 5
NM_174907.4 NP_777567.1 serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16085932 GOA
enables protein phosphatase regulator activity IMP
IMP: Inferred from mutant phenotype
20154705 GOA
enables protein-macromolecule adaptor activity IMP
IMP: Inferred from mutant phenotype
20154705 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of double-strand break repair IMP
IMP: Inferred from mutant phenotype
18614045 GOA
involved in regulation of double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
20154705 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
18614045 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20154705 GOA
part of protein phosphatase 4 complex IDA
IDA: Inferred from direct assay
20154705 GOA
part of protein phosphatase 4 complex IPI
IPI: Inferred from physical interaction
18614045 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP4R2 Protein Structure

PPP4R2

PPP4R2: PPP4R2 (1 - 205)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 4 regulatory subunit 2

PPP4R2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP4R2 Q9NY27 PPP4C Homo sapiens P60510
Anti Tag CoIP
28514442
Intra
PPP4R2 Q9NY27 PPP4C Homo sapiens P60510
Anti Bait CoIP
18614045
Intra
PPP4R2 Q9NY27 PPP4C Homo sapiens P60510
Anti Tag CoIP
33961781
Intra
PPP4R2 Q9NY27 PPP4C Homo sapiens P60510
BioID
28330616
Intra
PPP4R2 Q9NY27 PPP4C Homo sapiens P60510
Anti Tag CoIP
26496610
Intra
PPP4R2 Q9NY27 PPP4C Homo sapiens P60510
Anti Tag CoIP
18715871
Intra
PPP4R2 Q9NY27 PPP4C Homo sapiens P60510
TAP
16085932
Intra
PPP4R2 Q9NY27 PPP4C Homo sapiens P60510
Pull Down
28330616
Intra
PPP4R2 Q9NY27 PPP4C Homo sapiens P60510
Anti Tag CoIP
16085932
Intra
PPP4R2 Q9NY27 PTPA Homo sapiens Q15257
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Basal Cell Carcinoma, Infundibulocystic

  • Basal Cell Carcinoma With Follicular Differentiation

  • Infundibulocystic Basal Cell Carcinoma

  • Skin Infundibulocystic Basal Cell Carcinoma
Eccrine Papillary Adenocarcinoma

  • Digital Papillary Adenocarcinoma

  • Sweat Gland Adenocarcinoma

  • Digital Papillary Eccrine Carcinoma Of Skin
Malignant Acrospiroma

  • Eccrine Ductal Carcinoma

  • Hidradenocarcinoma

  • Anaplastic Syringoma

  • Eccrine Ductal Carcinoma Of Skin

  • Clear Cell Eccrine Carcinoma

  • Malignant Clear Cell Acrospiroma

  • Malignant Nodular/Clear Cell Hidradenoma

  • Primary Mucoepidermoid Cutaneous Carcinoma

  • Sweat Gland Adenocarcinoma
Eccrine Adenocarcinoma
Ulceroglandular Tularemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11030 PPP4R2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PPP4R2 VGNC VGNC:110347
Rattus norvegicus PPP4R2 RGD RGD:1307312
Canis familiaris PPP4R2 VGNC VGNC:44922
Bos taurus PPP4R2 VGNC VGNC:33270
Mus musculus PPP4R2 MGD MGI:3027896
Felis catus PPP4R2 VGNC VGNC:64328
Others PPP4R2 NCBI