country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

PPP2R2A - protein phosphatase 2 regulatory subunit Balpha Gene

Also Known as B55A; PR52A; PR55A; B55ALPHA; PR55alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5520

About PPP2R2A

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,291,508-26,372,680 (from NCBI)

This gene has 28 transcripts (splice variants), 141 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 15.8), placenta (RPKM 12.6) and 25 other tissues.

Summary

The product of this gene belongs to the Phosphatase 2 regulatory subunit B family. Protein Phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PPP2R2A Products (2)

mRNA	Protein	Name
NM_001177591.2	NP_001171062.1	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 2
NM_002717.4	NP_002708.1	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9847399	GOA
enables protein phosphatase regulator activity	IDA IDA: Inferred from direct assay	1849734	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	1849734	GOA
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	33108758	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	1849734	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	protein phosphatase 2, regulatory subunit B, alpha

PPP2R2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP2R2A	P63151	LRP1B	Homo sapiens	Q9NZR2	Validated Y2H	32814053
Intra	PPP2R2A	P63151	LRP1B	Homo sapiens	Q9NZR2	Y2H Pooling	32814053
Intra	PPP2R2A	P63151	LRP1B	Homo sapiens	Q9NZR2	Y2H Array	32814053
Intra	PPP2R2A	P63151	COL25A1	Homo sapiens	Q8NE08	Y2H Array	32814053
Intra	PPP2R2A	P63151	COL25A1	Homo sapiens	Q8NE08	Y2H Pooling	32814053
Intra	PPP2R2A	P63151	COL25A1	Homo sapiens	Q8NE08	Validated Y2H	32814053
Intra	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	Pull Down	20711181
Intra	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	BioID	28330616
Intra	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	Pull Down	28330616
Intra	PPP2R2A	P63151	PPP2R1A	Homo sapiens	P30153	Anti Tag CoIP	26496610
Intra	PPP2R2A	P63151	PPP2R1B	Homo sapiens	P30154	BioID	28330616
Intra	PPP2R2A	P63151	PPP2R1B	Homo sapiens	P30154	Pull Down	28330616
Intra	PPP2R2A	P63151	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	26496610
Intra	PPP2R2A	P63151	NEDD8	Homo sapiens	Q15843	Validated Y2H	32814053
Intra	PPP2R2A	P63151	NEDD8	Homo sapiens	Q15843	Y2H Array	32814053
Intra	PPP2R2A	P63151	NEDD8	Homo sapiens	Q15843	Y2H Pooling	32814053
Intra	PPP2R2A	P63151	FBXL20	Homo sapiens	Q96IG2	Anti Bait CoIP	34731788
Intra	PPP2R2A	P63151	FBXL20	Homo sapiens	Q96IG2	Confocal	34731788

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11011	PPP2R2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP2R2A	VGNC	VGNC:33255
Mus musculus	PPP2R2A	MGD	MGI:1919228
Macaca mulatta	PPP2R2A	VGNC	VGNC:84103
Canis familiaris	PPP2R2A	VGNC	VGNC:44907
Felis catus	PPP2R2A	VGNC	VGNC:69011
Rattus norvegicus	PPP2R2A	RGD	RGD:620919
Others	PPP2R2A	NCBI