Nxn - nucleoredoxin Gene

Also Known as l11Jus13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18230

Summary

Enables thioredoxin-disulfide reductase activity. Involved in circulatory system development; negative regulation of Wnt signaling pathway; and negative regulation of protein ubiquitination. Acts upstream of or within in utero embryonic development. Located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in Robinow syndrome. Orthologous to human NXN (nucleoredoxin). [provided by Alliance of Genome Resources, Apr 2022]

Nxn Products (1)

mRNA Protein Name
NM_008750.5 NP_032776.1 nucleoredoxin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16764867 MGI
enables thioredoxin-disulfide reductase (NADPH) activity IDA
IDA: Inferred from direct assay
9119370 MGI
Biological Process GO Annotation Evidence References Source
involved in circulatory system development IMP
IMP: Inferred from mutant phenotype
20970343 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
27996060 MGI
involved in negative regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20970343 MGI
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
20970343 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9119370 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleoredoxin

  • protein Red-1

Nxn Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Nxn P97346 SEC63 Homo sapiens Q9UGP8
Pull Down
21251912
Cross
Nxn P97346 SEC63 Homo sapiens Q9UGP8
Peptide Array
21251912
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-139049 NXN-188 / Phase 2

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09713 NXN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nxn NCBI NCBI:64359