NXN - nucleoredoxin Gene

Also Known as NRX; RRS2; TRG-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64359

About NXN

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:799,310-979,776 (from NCBI)

This gene has 12 transcripts (splice variants), 1 gene allele, 140 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in endometrium (RPKM 8.8), prostate (RPKM 6.7) and 24 other tissues.

Summary

This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]

NXN Products (2)

mRNA	Protein	Name
NM_001205319.1	NP_001192248.1	nucleoredoxin isoform 2
NM_022463.5	NP_071908.2	nucleoredoxin isoform 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	29276006	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NXN Protein Structure

Thioredoxin_8

Thioredoxin_6

0
100
200
300
400
435 a.a.

Protein Preferred Names	Protein Names
nucleoredoxin	nucleoredoxin 1

Related Diseases

Diseases	Alias
Robinow Syndrome, Autosomal Recessive 2	RRS2 Robinow, Autosomal Recessive Syndrome, Type 2
Robinow Syndrome, Autosomal Recessive 1	Robinow Syndrome, Autosomal Recessive Autosomal Recessive Robinow Syndrome Covesdem Syndrome RRS1 Costovertebral Segmentation Defect-Mesomelia Syndrome Rrs Costovertebral Segmentation Defect With Mesomelia, Formerly Covesdem Syndrome, Formerly Costovertebral Segmentation Defect With Mesomelia Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly Robinow, Autosomal Recessive Syndrome, Type 1
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Omodysplasia 2	OMOD2 Omodysplasia, Autosomal Dominant Autosomal Dominant Omodysplasia Omodysplasia Type 2 Omodysplasia, Type 2
Robinow Syndrome, Autosomal Dominant 3	Autosomal Dominant Robinow Syndrome 3 DRS3 Robinow, Autosomal Dominant Syndrome, Type 3
Omodysplasia 1	OMOD1 Autosomal Recessive Omodysplasia Omodysplasia Autosomal Recessive Omodysplasia Generalized Form Omodysplasia Type 1 Omodysplasia, Generalized Form Omodysplasia, Autosomal Recessive Micromelic Dysplasia, Congenital, With Dislocation Of Radius Micromelic Dysplasia Congenita With Dislocation Of Radius Micromelic Dysplasia-Dislocation Of Radius Syndrome Micromelic Dysplasia Congenital With Dislocation Of Radius Omodysplasia, Type 1
Vulvitis	Vulvitis Nos Inflammation Of Vulva Edeitis
Alacrima, Achalasia, And Mental Retardation Syndrome	AAMR Alacrima, Achalasia, And Intellectual Disability Syndrome Alacrima, Achalasia, And Impaired Intellectual Development Syndrome Intellectual Disability
Brachydactyly
Omodysplasia	Omodysplasia Type 1 Omodysplasia 2
Scoliosis
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-139049	NXN-188		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09713	NXN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NXN	RGD	RGD:1310489
Canis familiaris	NXN	VGNC	VGNC:44073
Bos taurus	NXN	VGNC	VGNC:32376
Mus musculus	NXN	MGD	MGI:109331
Macaca mulatta	NXN	VGNC	VGNC:75427
Felis catus	NXN	VGNC	VGNC:63935
Others	NXN	NCBI