PPP2R5C - protein phosphatase 2 regulatory subunit B'gamma Gene
Also Known as B56G; PR61G; B56gamma
Species: Homo sapiens
About PPP2R5C
This gene has 33 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 21.8), testis (RPKM 19.2) and 25 other tissues.
Summary
The product of this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PPP2R5C Products (10)
| mRNA | Protein | Name |
|---|---|---|
| NM_001161725.2 | NP_001155197.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform e |
| NM_001161726.2 | NP_001155198.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform f |
| NM_001352912.1 | NP_001339841.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b |
| NM_001352913.2 | NP_001339842.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform g |
| NM_001352914.2 | NP_001339843.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform h |
| NM_001352915.2 | NP_001339844.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform j |
| NM_001352916.2 | NP_001339845.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform i |
| NM_002719.4 | NP_002710.2 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform a |
| NM_178586.3 | NP_848701.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform b |
| NM_178587.3 | NP_848702.1 | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform c |
PPP2R5C Protein Structure
B56: Protein phosphatase 2A regulatory B subunit (B56 family) (30 - 438)
- 0
- 100
- 200
- 300
- 400
- 500
- 524 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform |
|
PPP2R5C Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PPP2R5C | Q13362 | PPP2R1A | Homo sapiens | P30153 | 21460856 | |
|
Intra
|
PPP2R5C | Q13362 | PPP2R1A | Homo sapiens | P30153 | 33961781 | |
|
Intra
|
PPP2R5C | Q13362 | PPP2R1A | Homo sapiens | P30153 | 21460856 | |
|
Intra
|
PPP2R5C | Q13362 | TP53 | Homo sapiens | P04637 | 21460856 | |
|
Intra
|
PPP2R5C | Q13362 | TP53 | Homo sapiens | P04637 | 25241761 | |
|
Intra
|
PPP2R5C | Q13362 | MDM2 | Homo sapiens | Q00987 | 21460856 | |
|
Intra
|
PPP2R5C | Q13362 | MDM2 | Homo sapiens | Q00987 | 21460856 | |
|
Intra
|
PPP2R5C | Q13362 | PPP2CA | Homo sapiens | P67775 | 1328865 | |
|
Intra
|
PPP2R5C | Q13362 | PPP2CA | Homo sapiens | P67775 | 21460856 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cornelia De Lange Syndrome |
|
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| Mosaic Variegated Aneuploidy Syndrome |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | PPP2R5C | VGNC | VGNC:33262 |
| Mus musculus | PPP2R5C | MGD | MGI:1349475 |
| Canis familiaris | PPP2R5C | VGNC | VGNC:44915 |
| Rattus norvegicus | PPP2R5C | RGD | RGD:1585097 |
| Felis catus | PPP2R5C | VGNC | VGNC:69017 |
| Others | PPP2R5C | NCBI |