2304465-89-0
2304465-89-0
Chemical Structure
F5446
- CAS No.: 2304465-89-0
- Formula:C26H17ClN2O8S
- Molecular Weight:552.94
IUPAC Name: 3-(3,3-dimethyl-1-phenyl-1,3-dihydrobenzo[c]thiophen-1-yl)-N-methylpropan-1-amine
InChIKey: MLPQCOLPRPRADV-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2=C(C3=O)NC=C2C(OCC4=CC=CC=C4)=O)=C(N1S(=O)(C5=CC=C(C=C5)Cl)=O)C3=O)OC
Biological Activity: F5446 (Compound 1) is a selective small molecule inhibitor of SUV39H1 methyltransferase. F5446 decreases H3K9me3 deposition at the FAS promoter, increases Fas expression and increases colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. F5446 suppresses human colon tumor xenograft growth in vivo[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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F5446 | 99.73% | F5446 (Compound 1) is a selective small molecule inhibitor of SUV39H1 methyltransferase. F5446 decreases H3K9me3 deposition at the FAS promoter, increases Fas expression and increases colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. F5446 suppresses human colon tumor xenograft growth in vivo. | ||||||||||||||||||||
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References
- [1]. Chunwan Lu, et al. Small molecule histone methyltransferase SUV39H1 inhibitor and uses thereof. US10577371B2. 2018.
- [2]. Lu C, et al. SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth. Cancer Lett. 2020 Apr 28;476:87-96. [Content Brief]
- [3]. Lu C, et al. SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion. Cancer Immunol Res. 2019 Mar;7(3):414-427. [Content Brief]
