56741-95-8
Chemical Structure
Bropirimine
Synonym(s): U-54461; U-54461S; PNU-54461
- CAS No.: 56741-95-8
- Formula:C10H8BrN3O
- Molecular Weight:266.10
IUPAC Name: 2-amino-5-bromo-6-phenylpyrimidin-4(3H)-one
InChIKey: CIUUIPMOFZIWIZ-UHFFFAOYSA-N
SMILES: O=C1NC(N)=NC(C2=CC=CC=C2)=C1Br
Biological Activity: Bropirimine (U-54461; U-54461S; PNU-54461) is an orally active TLR7 agonist. Bropirimine inhibits RANKL-induced osteoclast differentiation of mouse bone marrow-derived macrophages (BMMs). Bropirimine exhibits dose-dependent direct inhibitory effects on colony formation of cultured KK-47 and 724 cells. Bropirimine can be used for the study of cancers and bone metabolic disorders such as osteoporosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bropirimine | 99.94% | Bropirimine (U-54461; U-54461S; PNU-54461) is an orally active TLR7 agonist. Bropirimine inhibits RANKL-induced osteoclast differentiation of mouse bone marrow-derived macrophages (BMMs). Bropirimine exhibits dose-dependent direct inhibitory effects on colony formation of cultured KK-47 and 724 cells. Bropirimine can be used for the study of cancers and bone metabolic disorders such as osteoporosis. | ||||||||||||||||||||
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References
- [1]. Suzuki H, et al. Bropirimine inhibits osteoclast differentiation through production of interferon-β. Biochem Biophys Res Commun. 2015;467(1):146‐151. [Content Brief]
- [2]. Tei Y, et al. In vitro antitumor activity of bropirimine against urinary bladder tumor cells. Anticancer Res. 2002 May-Jun;22(3):1667-71. [Content Brief]
- [3]. Fujioka T, et al. Antitumor effects of oral administration of an interferon-inducing pyrimidinone, Bropirimine, on murine renal-cell carcinoma. Cancer Chemother Pharmacol. 1995;36(1):7-12. [Content Brief]
