1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Amrinone

Amrinone (Synonyms: Inamrinone)

Cat. No.: HY-B1294 Purity: >98.0%
Handling Instructions

Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent.

For research use only. We do not sell to patients.

Amrinone Chemical Structure

Amrinone Chemical Structure

CAS No. : 60719-84-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 39 In-stock
Estimated Time of Arrival: December 31
25 mg USD 35 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg USD 85 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent[1][2][3].

In Vitro

Amrinone (Inamrinone) produced a dose-dependent inhibition of ADP-induced rat platelet aggregation in vitro as well as ex vivo in rats. The proliferation of human aortic smooth muscle cells in culture stimulated with FBS or PDGF was also inhibited by amrinone[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Amrinone (Inamrinone) is administered subcutaneously to rats at a dose of 10 mg/kg/day for 14 days, significant reduction of neointimal thickness was noted[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

187.20

Formula

C₁₀H₉N₃O

CAS No.

60719-84-8

SMILES

O=C1C(N)=CC(C2=CC=NC=C2)=CN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

AmrinoneInamrinonePhosphodiesterase (PDE)intractablemyocardialfailureinotropiccardiotonicplateletInhibitorinhibitorinhibit

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Amrinone
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