CENPF - centromere protein F Gene

Also Known as CENF; hcp-1; CILD31; STROMS; PRO1779

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1063

About CENPF

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:214,603,195-214,664,571 (from NCBI)

This gene has 5 transcripts (splice variants), 189 orthologues and is associated with 4 phenotypes. Broad expression in bone marrow (RPKM 9.7), testis (RPKM 6.0) and 15 other tissues.

Summary

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with Cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

CENPF Products (1)

mRNA	Protein	Name
NM_016343.4	NP_057427.3	centromere protein F

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15677469	GOA
enables dynein complex binding	IDA IDA: Inferred from direct assay	12974617	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7642639	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	7642639	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	16252009	GOA
involved in kidney development	IMP IMP: Inferred from mutant phenotype	25564561	GOA
involved in metaphase chromosome alignment	IDA IDA: Inferred from direct assay	15870278	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	7542657	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15677469	GOA
involved in protein transport	IDA IDA: Inferred from direct assay	12974617	GOA
involved in protein transport	IMP IMP: Inferred from mutant phenotype	17600710	GOA
involved in regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	7651420	GOA
involved in ventricular system development	IMP IMP: Inferred from mutant phenotype	25564561	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	7542657	GOA
part of ciliary transition fiber	IMP IMP: Inferred from mutant phenotype	25564561	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12974617	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	7542657	GOA
located in midbody	IDA IDA: Inferred from direct assay	7651420	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	12154071	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	7542657	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7542657	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	7542657	GOA
located in spindle	IDA IDA: Inferred from direct assay	7651420	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	7542657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPF Protein Structure

CENP-F_N

CENP-F_leu_zip

CENP-F_C_Rb_bdg

0
500
1000
1500
2000
2500
3114 a.a.

Protein Preferred Names	Protein Names
centromere protein F	AH antigen

CENPF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CENPF	P49454	NUP133	Homo sapiens	Q8WUM0	Anti Bait CoIP	17363900
Intra	CENPF	P49454	NDEL1	Homo sapiens	Q9GZM8	Y2H	17600710
Intra	CENPF	P49454	NDEL1	Homo sapiens	Q9GZM8	Y2H	17043677
Intra	CENPF	P49454	NDEL1	Homo sapiens	Q9GZM8	Pull Down	17600710

Cross: Cross-species interaction Intra: Intraspecies interaction

CENPF Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81416	CENPF Antibody (YA1161)	IHC-P	Human
HY-P81416A	CENPF Antibody (YA1161)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Stromme Syndrome	Jejunal Atresia With Microcephaly And Ocular Anomalies Apple Peel Syndrome With Microcephaly And Ocular Anomalies STROMS Cild31 Lethal Fetal Brain Malformation-Duodenal Atresia-Bilateral Renal Hypoplasia Syndrome Ciliary Dyskinesia, Primary, 31, Formerly Cild31, Formerly Primary Ciliary Dyskinesia 31 Apple-Peel Intestinal Atresia-Ocular Anomalies-Microcephaly Syndrome Jejunal Atresia-Microcephaly-Ocular Anomalies Syndrome Ciliary Dyskinesia, Primary, 31 Dyskinesia, Ciliary, Primary, Type 31
Graft-Versus-Host Disease	Graft-Versus-Host Disease, Susceptibility To Graft Versus Host Disease GVHDS Graft-Versus-Host Disease, Protection Against Gvh Graft-Vs-Host Disease Gvhd - [Graft-Versus-Host Disease] Graft-Versus-Host Reaction Or Disease Gvh - [Graft-Versus-Host] Disease Gvh - [Graft-Versus-Host] Reaction
Intestinal Atresia
Cystinuria	CSNU Cystinuria Type B Cystinuria Type A Cystinuria, Type I, Formerly Csnu1, Formerly Cystinuria, Type Ii, Formerly Cystinuria, Type Iii, Formerly Csnu3, Formerly Cystinuria, Type Non-I, Formerly Cystinuria-Lysinuria Cystinuria-Lysinuria Syndrome Csnu1 Csnu3 Cystinuria 1 Cystinuria Type A/B Cystinuria Type I Cystinuria Type Ii Cystinuria Type Iii Cystinuria Type Non-I Cystinuria, Type A/B Cystinuria Type 1 Cystinuria - Lysinuria Csnu - [Cystinuria] Cystine Disease
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Mosaic Variegated Aneuploidy Syndrome 1	Mva Syndrome MVA1 Mosaic Variegated Aneuploidy Syndrome, Type 1 Mosaic Variegated Aneuploidy Syndrome Congenital Chromosomal Disease
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Familial Apolipoprotein C-Ii Deficiency	Familial Apoc-Ii Deficiency Familial Apoc2 Deficiency C-Ii Anapolipoproteinemia Hyperlipoproteinemia, Type 1b Hyperlipoproteinemia, Type Ib Hyperlipoproteinemia Type I
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02479	CENPF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20374	Cenpf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26884	Cenpf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CENPF	VGNC	VGNC:27176
Mus musculus	CENPF	MGD	MGI:1313302
Felis catus	CENPF	VGNC	VGNC:107851
Rattus norvegicus	CENPF	RGD	RGD:628667
Macaca mulatta	CENPF	VGNC	VGNC:71009
Others	CENPF	NCBI