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54069

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9

Inhibitors & Agonists

6

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19855
    AZD-5069
    Maximum Cited Publications
    11 Publications Verification

    		 CXCR Endocrinology Cancer
    AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.
    AZD-5069
  • HY-114162
    VTP50469
    Maximum Cited Publications
    11 Publications Verification

    SNDX-50469

    		 Epigenetic Reader Domain Apoptosis Cancer
    VTP50469 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 has potently anti-leukemia activity .
    VTP50469
  • HY-163102
    IA-14069

    		TNF Receptor NF-κB Inflammation/Immunology
    IA-14069 is an orally active tumor necrosis factor-α (TNF-α) inhibitor. IA-14069 binds directly to TNF-α and TNF-α-triggered signaling (p-IκBα and NF-κB p65) activities. Additionally, IA-14069 exerts a suppressive effect on Dextran sodium sulfate (HY-116282C) (DSS)-induced colitis. IA-14069 can be used for the research of Rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) .
    IA-14069
  • HY-114162A
    VTP50469 fumarate
    Maximum Cited Publications
    11 Publications Verification

    SNDX-50469 fumarate

    		 Epigenetic Reader Domain Apoptosis Cancer
    VTP50469 fumarate is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 fumarate has potently anti-leukemia activity .
    VTP50469 fumarate
  • HY-121825
    U-44069

    		Prostaglandin Receptor Cardiovascular Disease
    U-44069 is a stable prostaglandin (PG) H2 analogue and a potent vasoconstrictor. U-44069 induces Ca influx at preglomerular vessels .
    U-44069
  • HY-114162R
    VTP50469 (Standard)

    SNDX-50469 (Standard)

    		 Reference Standards Epigenetic Reader Domain Apoptosis Cancer
    VTP50469 (Standard) is the analytical standard of VTP50469. This product is intended for research and analytical applications. VTP50469 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 has potently anti-leukemia activity .
    VTP50469 (Standard)
  • HY-114162B
    VTP50469 mesylate

    SNDX-50469 mesylate

    		 Epigenetic Reader Domain Apoptosis Cancer
    VTP50469 mesylate is a potent, and selective Menin-MLL1 inhibitor that effectively targets MLL-rearranged and NPM1c+ leukemia. VTP50469 mesylate selectively kills cell lines with MLL rearrangements and NPM1c+ mutations. VTP50469 mesylate displaces Menin from protein complexes and inhibits MLL's chromatin occupancy at specific genes, leading to significant changes in gene expression, differentiation, and apoptosis. VTP50469 demonstrates dramatic reductions in leukemia burden in patient-derived xenograft models of MLL-r acute myeloid leukemia and MLL-r acute lymphoblastic leukemia, with some mice remaining disease-free for over a year post-treatment.
    VTP50469 mesylate
  • HY-122178
    5-trans U-44069

    		PGE synthase Cardiovascular Disease
    5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 (HY-121825). 5-trans U-44069 inhibits prostaglandin E2 synthase activity .
    5-trans U-44069
  • HY-176021
    U-44069 serinol amide

    		Prostaglandin Receptor Cardiovascular Disease
    U-44069 serinol amide is a derivative of U-44069 (HY-121825). U-44069 serinol amide is a stable analog of the endoperoxide prostaglandin H2 (HY-136500). U-44069 serinol amide is a vasoconstrictor that can induce preglomerular Ca 2+ influx .
    U-44069 serinol amide

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