ABI3 - ABI family member 3 Gene

Also Known as NESH; SSH3BP3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51225

About ABI3

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:49,210,707-49,223,225 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues and 2 paralogues. Broad expression in spleen (RPKM 23.3), lymph node (RPKM 10.1) and 21 other tissues.

Summary

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ABI3 Products (2)

mRNA Protein Name
NM_001135186.2 NP_001128658.2 ABI gene family member 3 isoform 2
NM_016428.3 NP_057512.2 ABI gene family member 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to tumor cell IMP
IMP: Inferred from mutant phenotype
21223585 GOA
NOT acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
17101133 GOA
involved in positive regulation of cellular senescence IMP
IMP: Inferred from mutant phenotype
21223585 GOA
acts upstream of or within regulation of cell migration IDA
IDA: Inferred from direct assay
11956071 GOA
Cellular Component GO Annotation Evidence References Source
part of SCAR complex IDA
IDA: Inferred from direct assay
17101133 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
17101133 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABI3 Protein Structure

Abi_HHR

Abi_HHR: Abl-interactor HHR (93 - 165)

SH3_9

SH3_9: Variant SH3 domain (316 - 363)

  • 0
  • 100
  • 200
  • 300
  • 366 a.a.
Protein Preferred Names Protein Names

ABI gene family member 3

  • new molecule including SH3

ABI3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ABI3 Q9P2A4 KRT13 Homo sapiens A1A4E9
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 b2r8y4_human Homo sapiens B2R8Y4
Y2H Array
25416956
Intra
ABI3 Q9P2A4 EIF3S3 Homo sapiens Q6IB98
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 EIF3S3 Homo sapiens Q6IB98
Y2H Array
25416956
Intra
ABI3 Q9P2A4 EIF3S3 Homo sapiens Q6IB98
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 RUNX1T1 Homo sapiens Q06455-4
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 FBF1 Homo sapiens Q8TES7-6
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 FBF1 Homo sapiens Q8TES7-6
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 FBF1 Homo sapiens Q8TES7-6
Y2H Array
25416956
Intra
ABI3 Q9P2A4 KRT38 Homo sapiens O76015
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 KRT38 Homo sapiens O76015
Y2H Array
32296183
Intra
ABI3 Q9P2A4 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
ABI3 Q9P2A4 MIS18A Homo sapiens Q9NYP9
Y2H Array
32296183
Intra
ABI3 Q9P2A4 MIS18A Homo sapiens Q9NYP9
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 GNG13 Homo sapiens Q9P2W3
Validated Y2H
32296183
Intra
ABI3 Q9P2A4 EMILIN1 Homo sapiens Q9Y6C2-2
Validated Y2H
32296183
Intra
ABI3 Q9P2A4 EMILIN1 Homo sapiens Q9Y6C2-2
Y2H Array
32296183
Intra
ABI3 Q9P2A4 EMILIN1 Homo sapiens Q9Y6C2-2
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
ABI3 Q9P2A4 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra
ABI3 Q9P2A4 KRT28 Homo sapiens Q7Z3Y7
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 KRT28 Homo sapiens Q7Z3Y7
Y2H Array
32296183
Intra
ABI3 Q9P2A4 WASF1 Homo sapiens Q92558
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 WASF1 Homo sapiens Q92558
Y2H Array
32296183
Intra
ABI3 Q9P2A4 CENPQ Homo sapiens Q7L2Z9
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 CENPQ Homo sapiens Q7L2Z9
Y2H Array
32296183
Intra
ABI3 Q9P2A4 KANK2 Homo sapiens Q63ZY3
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 KANK2 Homo sapiens Q63ZY3
Y2H Array
25416956
Intra
ABI3 Q9P2A4 DESI1 Homo sapiens Q6ICB0
Y2H Array
32296183
Intra
ABI3 Q9P2A4 DESI1 Homo sapiens Q6ICB0
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 NUP58 Homo sapiens Q9BVL2
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 NUP58 Homo sapiens Q9BVL2
Y2H
21516116
Intra
ABI3 Q9P2A4 NUP58 Homo sapiens Q9BVL2
Y2H Array
25416956
Intra
ABI3 Q9P2A4 KRT24 Homo sapiens Q2M2I5
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 KRT24 Homo sapiens Q2M2I5
Y2H Array
32296183
Intra
ABI3 Q9P2A4 WAS Homo sapiens P42768
Y2H Array
25416956
Intra
ABI3 Q9P2A4 EVL Homo sapiens Q9UI08
Y2H Array
29892012
Intra
ABI3 Q9P2A4 EVL Homo sapiens Q9UI08
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 EVL Homo sapiens Q9UI08
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 SH3BP1 Homo sapiens Q9Y3L3
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 SH3BP1 Homo sapiens Q9Y3L3
Validated Y2H
32296183
Intra
ABI3 Q9P2A4 SH3BP1 Homo sapiens Q9Y3L3
Y2H Array
32296183
Intra
ABI3 Q9P2A4 EIF3M Homo sapiens Q7L2H7
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 EIF3M Homo sapiens Q7L2H7
Y2H Array
32296183
Intra
ABI3 Q9P2A4 PSMA1 Homo sapiens P25786
Y2H Array
25416956
Intra
ABI3 Q9P2A4 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 MED29 Homo sapiens Q9NX70
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 MED29 Homo sapiens Q9NX70
Y2H Array
32296183
Intra
ABI3 Q9P2A4 GRB2 Homo sapiens P62993
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 GRB2 Homo sapiens P62993
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 GRB2 Homo sapiens P62993
Y2H Array
25416956
Intra
ABI3 Q9P2A4 BLOC1S5 Homo sapiens Q8TDH9
Y2H Array
32296183
Intra
ABI3 Q9P2A4 BLOC1S5 Homo sapiens Q8TDH9
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
ABI3 Q9P2A4 EVL Homo sapiens Q9UI08-2
Validated Y2H
32296183
Intra
ABI3 Q9P2A4 KRT14 Homo sapiens P02533
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 KRT14 Homo sapiens P02533
Y2H Array
32296183
Intra
ABI3 Q9P2A4 EIF3H Homo sapiens O15372
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 EIF3H Homo sapiens O15372
Y2H Array
19060904
Intra
ABI3 Q9P2A4 EIF3H Homo sapiens O15372
Y2H Pooling
19060904
Intra
ABI3 Q9P2A4 EIF3H Homo sapiens O15372
Y2H Array
32296183
Intra
ABI3 Q9P2A4 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
ABI3 Q9P2A4 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
ABI3 Q9P2A4 NCK2 Homo sapiens O43639
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 RUFY3 Homo sapiens Q7L099
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 RUFY3 Homo sapiens Q7L099
Y2H Array
32296183
Intra
ABI3 Q9P2A4 FARSA Homo sapiens Q9Y285
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 FARSA Homo sapiens Q9Y285
Y2H Array
25416956
Intra
ABI3 Q9P2A4 KIAA0408 Homo sapiens Q6ZU52
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 KIAA0408 Homo sapiens Q6ZU52
Y2H Array
32296183
Intra
ABI3 Q9P2A4 SUFU Homo sapiens Q9UMX1
Validated Y2H
32296183
Intra
ABI3 Q9P2A4 CEP44 Homo sapiens Q9C0F1
Y2H Array
32296183
Intra
ABI3 Q9P2A4 CEP44 Homo sapiens Q9C0F1
Y2H Pooling
16189514
Intra
ABI3 Q9P2A4 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra
ABI3 Q9P2A4 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 ARMC7 Homo sapiens Q9H6L4
Y2H Array
25416956
Intra
ABI3 Q9P2A4 HOMER1 Homo sapiens Q86YM7
Y2H Array
32296183
Intra
ABI3 Q9P2A4 HOMER1 Homo sapiens Q86YM7
Y2H Pooling
16189514
Intra
ABI3 Q9P2A4 HOMER1 Homo sapiens Q86YM7
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 VASP Homo sapiens P50552
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 VASP Homo sapiens P50552
Y2H Array
32296183
Intra
ABI3 Q9P2A4 VASP Homo sapiens P50552
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 VASP Homo sapiens P50552
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 MAGEA12 Homo sapiens P43365
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 MAGEA12 Homo sapiens P43365
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 IHO1 Homo sapiens Q8IYA8
Y2H Array
32296183
Intra
ABI3 Q9P2A4 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 IFT20 Homo sapiens Q8IY31-3
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 IFT20 Homo sapiens Q8IY31-3
Y2H Array
32296183
Intra
ABI3 Q9P2A4 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 NDEL1 Homo sapiens Q9GZM8
Y2H Array
32296183
Intra
ABI3 Q9P2A4 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
ABI3 Q9P2A4 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 KLC4 Homo sapiens Q9NSK0
Y2H Array
25416956
Intra
ABI3 Q9P2A4 KLC4 Homo sapiens Q9NSK0
Y2H Prey Pooling
25416956
Intra
ABI3 Q9P2A4 KLC4 Homo sapiens Q9NSK0
Validated Y2H
25416956
Intra
ABI3 Q9P2A4 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
Intra
ABI3 Q9P2A4 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Intra
ABI3 Q9P2A4 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

  • Nasu-Hakola Disease

  • Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

  • Plosl

  • Nhd

  • Presenile Dementia With Bone Cysts

  • Plo-Sl

  • PLOSL1

  • Dementia, Prefrontal, With Bone Cysts

  • Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease

  • Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00101 ABI3BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00100 ABI3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ABI3 RGD RGD:1311794
Bos taurus ABI3 VGNC VGNC:25507
Mus musculus ABI3 MGD MGI:1913860
Felis catus ABI3 VGNC VGNC:59488
Macaca mulatta ABI3 VGNC VGNC:69549
Canis familiaris ABI3 VGNC VGNC:37476
Others ABI3 NCBI