KRT14 - keratin 14 Gene

Also Known as K14; NFJ; CK14; EBS1; EBS3; EBS4; EBS1A; EBS1B; EBS1C; EBS1D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3861

About KRT14

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,582,279-41,586,895 (from NCBI)

This gene has 3 transcripts (splice variants), 74 orthologues, 68 paralogues and is associated with 18 phenotypes. Restricted expression toward skin (RPKM 3550.7).

Summary

This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the Cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]

KRT14 Products (1)

mRNA	Protein	Name
NM_000526.5	NP_000517.3	keratin, type I cytoskeletal 14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables keratin filament binding	IPI IPI: Inferred from physical interaction	20346438	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10852826	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hair cycle	IDA IDA: Inferred from direct assay	21916889	GOA
involved in intermediate filament bundle assembly	IMP IMP: Inferred from mutant phenotype	11724817	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11724817	GOA
located in intermediate filament	IDA IDA: Inferred from direct assay	10852826	GOA
located in keratin filament	IDA IDA: Inferred from direct assay	7679677	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11724817	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT14 Protein Structure

Filament

0
100
200
300
400
472 a.a.

Protein Preferred Names	Protein Names
keratin, type I cytoskeletal 14	cytokeratin 14

KRT14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT14	P02533	BFSP2	Homo sapiens	Q13515	Validated Y2H	32296183
Intra	KRT14	P02533	KRT78	Homo sapiens	Q8N1N4	Validated Y2H	32296183
Intra	KRT14	P02533	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	KRT14	P02533	PUS10	Homo sapiens	Q3MIT2	Validated Y2H	32296183
Intra	KRT14	P02533	KRT80	Homo sapiens	Q6KB66-2	Validated Y2H	32296183
Intra	KRT14	P02533	KRT72	Homo sapiens	Q14CN4	Validated Y2H	32296183
Intra	KRT14	P02533	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	KRT14	P02533	CTTNBP2	Homo sapiens	Q8WZ74	Validated Y2H	32296183
Intra	KRT14	P02533	KRT3	Homo sapiens	P12035	Validated Y2H	32296183
Intra	KRT14	P02533	KRT79	Homo sapiens	Q5XKE5	Validated Y2H	32296183
Intra	KRT14	P02533	KRT6C	Homo sapiens	P48668	Y2H Prey Pooling	32296183
Intra	KRT14	P02533	KRT6C	Homo sapiens	P48668	Validated Y2H	32296183
Intra	KRT14	P02533	PLEC	Homo sapiens	Q15149	Anti Tag CoIP	33961781
Intra	KRT14	P02533	KRT1	Homo sapiens	P04264	Validated Y2H	32296183
Intra	KRT14	P02533	SMARCE1	Homo sapiens	Q969G3	Validated Y2H	32296183
Intra	KRT14	P02533	KRT5	Homo sapiens	P13647	Solution Sedimentation	10852826
Intra	KRT14	P02533	UBASH3A	Homo sapiens	P57075-2	Validated Y2H	32296183
Intra	KRT14	P02533	KRT81	Homo sapiens	Q14533	Validated Y2H	32296183
Intra	KRT14	P02533	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	KRT14	P02533	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	KRT14	P02533	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	KRT14	P02533	PRPH	Homo sapiens	P41219	Validated Y2H	32296183
Intra	KRT14	P02533	PKP1	Homo sapiens	Q13835-2	Solution Sedimentation	10852826

Cross: Cross-species interaction Intra: Intraspecies interaction

KRT14 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82131	Cytokeratin 14 Antibody (YA1876)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P83920	KRT14 Antibody (YA3617)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Monkey
HY-P83920A	KRT14 Antibody (YA3617)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Monkey
HY-P85938	Cytokeratin Antibody (YA5630)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86026	Cytokeratin Antibody (YA5718)	IHC-P, ELISA	Human, Mouse, Rat
HY-P86245	Cytokeratin 14 Antibody (YA5937)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86663	Cytokeratin 14 Antibody (YA6355)	IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Epidermolysis Bullosa Simplex 1a, Generalized Severe	Epidermolysis Bullosa Simplex, Dowling-Meara Type Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type EBS1A Ebsdm Epidermolysis Bullosa Simplex Dowling-Meara Type Epidermolysis Bullosa Simplex, Herpetiformis Ebs-Dm Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type Ebs-Gen Sev Epidermolysis Bullosa Herpetiformis Dowling-Meara Type Generalized Severe Epidermolysis Bullosa Simplex Dowling-Meara Type Epidermolysis Bullosa Simplex Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form Autosomal Dominant Generalized Ebs, Severe Form Epidermolysis Bullosa Simplex Herpetiformis Dm-Ebs Epidermolysis Bullosa Simplex, Generalized Severe Epidermolysis Bullosa Herpetiformis, Dowling-Meara Epidermolysis Bullosa Herpetiformis Dowling-Meara
Epidermolysis Bullosa Simplex 1d, Generalized, Intermediate Or Severe, Autosomal Recessive	EBS1D Epidermolysis Bullosa Simplex, Autosomal Recessive 1 Autosomal Recessive Generalized Epidermolysis Bullosa Simplex Autosomal Recessive Generalized Ebs Ebsb1 Epidermolysis Bullosa Simplex, Autosomal Recessive, Type 1
Dermatopathia Pigmentosa Reticularis	DPR
Naegeli-Franceschetti-Jadassohn Syndrome	Naegeli Syndrome Nfj Syndrome NFJS Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis Dpr Franceschetti-Jadassohn Syndrome Nfjs/Dpr
Epidermolysis Bullosa Simplex 1c, Localized	Epidermolysis Bullosa Of Hands And Feet EBS1C Ebs, Acral Form Epidermolysis Bullosa Simplex 1c, Weber-Cockayne Type Epidermolysis Bullosa Simplex, Localized Epidermolysis Bullosa Simplex, Weber-Cockayne Type Wc-Ebs
Epidermolysis Bullosa Simplex 1b, Generalized Intermediate	EBS1B Epidermolysis Bullosa Simplex, Koebner Type Epidermolysis Bullosa Simplex 1b, Koebner Type Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Intermediate Form Autosomal Dominant Generalized Ebs, Intermediate Form Epidermolysis Bullosa Simplex, Kobner Type Ebs2 Ebs Generalized Epidermolysis Bullosa Simplex 2 K-Ebs
Epidermolysis Bullosa Simplex Localized Type	Epidermolysis Bullosa Simplex, Weber-Cockayne Type Weber-Cockayne Syndrome Ebs-Loc Epidermolysis Bullosa Simplex Of Palms And Soles Epidermolysis Bullosa Simplex Weber-Cockayne Type Epidermolysis Bullosa Simplex, Localized Epidermolysis Bullosa Of Hands And Feet Weber-Cockayne Type Epidermolysis Bullosa Simplex Localized Epidermolysis Bullosa Simplex Localized Ebs
Epidermolysis Bullosa Simplex 2f, With Mottled Pigmentation	Epidermolysis Bullosa Simplex With Mottled Pigmentation Ebsmp Speckled Hyperpigmentation With Punctate Palmoplantar Keratoses And Childhood Blistering Ebs-Mp EBS2F Ebs With Mottled Pigmentation Epidermolysis Bullosa Simplex-Mp Speckled Hyperpigmentation, Palmo-Plantar Punctate Keratoses And Childhood Blistering Epidermolysis Bullosa Simplex, With Mottled Pigmentation
Epidermolysis Bullosa Simplex Generalized Type	Epidermolysis Bullosa Simplex, Koebner Type Epidermolysis Bullosa Simplex Koebner Type Epidermolysis Bullosa Simplex, Generalized Ebs, Generalized Ebs-K Epidermolysis Bullosa Simplex, Generalized Non-Dowling-Meara Generalized Ebs Epidermolysis Bullosa Simplex Kobner
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Epidermolysis Bullosa	Acantholysis Bullosa Eb
Sjogren-Larsson Syndrome	Sjögren-Larsson Syndrome SLS Faldh Deficiency Fatty Aldehyde Dehydrogenase Deficiency Fatty Acid Alcohol Oxidoreductase Deficiency Ichthyosis, Spastic Neurologic Disorder, And Oligophrenia Sjogren Larsson Syndrome Fatty Alcohol:Nad+ Oxidoreductase Deficiency Sjogren-Larsson'S Syndrome Fadh Deficiency Fao Deficiency Congenital Icthyosis Mental Retardation Spasticity Syndrome Ichthyosis Oligophrenia Syndrome Sjoegren-Larsson Syndrome
Myoepithelioma	Benign Myoepithelioma Myoepithelial Adenoma Myoepithelial Neoplasm Malignant Myoepithelioma
Skin Benign Neoplasm	Neoplasm Of Skin By Site Tumor Of The Skin Skin Tumor Benign Neoplasm Of Skin Skin Neoplasms
Papilloma	Papillomatosis
Ameloblastoma	Adenoameloblastoma
Adermatoglyphia	ADERM Immigration Delay Disease Absence Of Fingerprints Adg Congenital Absence Of Fingerprints Isolated Congenital Adermatoglyphia Fingerprints, Absence Of Skin Abnormalities
Oral Hairy Leukoplakia	Hairy Leukoplakia Leukoplakia, Hairy Hairy Leucoplakia
Alopecia
Pleomorphic Adenoma	Mixed Tumor Of The Salivary Gland Adenoma Pleomorphic Adenoma, Pleomorphic Mixed Salivary Gland Tumor Mixed Tumor, Not Otherwise Specified
Mucoepidermoid Carcinoma	Mec Salivary Gland Mucoepidermoid Carcinoma C3772 Carcinoma Mucoepidermoid Carcinoma, Mucoepidermoid
Craniopharyngioma	Neoplasm Of Rathke'S Pouch Adamantinomatous Tumor Craniopharyngeal Duct Tumor Dysodontogenic Epithelial Tumor Rathke'S Pouch Tumor
Brooke-Spiegler Syndrome	Cyld Cutaneous Syndrome Spiegler-Brooke Syndrome Familial Cylindromatosis BRSS Bss Sbs Multiple Familial Trichoepithelioma Ancell-Spiegler Cylindromas Familial Multiple Trichoepithelioma Trichoepithelioma Fc Mft Multiple Familial Trichoepitheliomas Ccs Turban Tumor Syndrome Schilbach-Rott Syndrome Eccrine Dermal Cylindroma Familial Multiple Trichoepitheliomata
Breast Myoepithelial Carcinoma
Odontoma
Trachea Carcinoma In Situ	Carcinoma In Situ Of Trachea Tracheal Carcinoma In Situ Severe Epithelial Dysplasia Of Trachea Intraepithelial Neoplasia Of Trachea, High Grade
Laryngeal Mucoepidermoid Carcinoma	Mucoepidermoid Carcinoma Of Larynx
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa
Ichthyosis Vulgaris	Ichthyosis Simplex Dominant Congenital Ichthyosiform Erythroderma Common Ichthyosis Fish Scale Disease VI Ichthyoses Congenital Ichthyosis
Benign Breast Adenomyoepithelioma	Benign Adenomyoepithelioma Of The Breast
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Skin Papilloma	Cutaneous Papilloma Papilloma Of Skin Papilloma Skin
Oncocytic Breast Carcinoma
Bullous Pemphigoid	Benign Pemphigus Senile Dermatitis Herpetiformis Old Age Pemphigus Parapemphigus Pemphigoid Pemphigoid Bullous Pemphigoid, Bullous
Breast Fibroadenoma	Fibroadenoma Fibroadenoma Of Breast Juvenile Fibroadenoma Of Breast Cellular Fibroadenoma Complex Fibroadenoma Of Breast Juvenile Fibroadenoma Fibroadenoma Nos Fibroadenoma Unspecified Site
Keratosis	Actinic Keratosis Hyperkeratosis
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Cholesteatoma Of Middle Ear	Cholesteatoma Epidermosis Of Ear Epidermosis Of Middle Ear Middle Ear Cholesteatoma Cholesteatoma Of Middle Ear And Mastoid Cholesteatoma Of Middle Ear And/Or Mastoid Cholesteatoma Of The Middle Ear Congenital Cholesteatoma Primary Acquired Cholesteatoma Secondary Acquired Cholesteatoma Cholesteatoma Middle Ear Cholesteatoma, Middle Ear Cholesterolosis Of Middle Ear Cholesterosis Of Ear Cholesterosis Of Middle Ear Cholesteatoma Nos Epidermoid Cholesteatoma Middle Ear Granuloma
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Breast Intraductal Proliferative Lesion	Intraductal Proliferative Lesion Intraductal Proliferative Lesion Of The Breast
Sublingual Gland Adenoid Cystic Carcinoma
Ceruminous Adenocarcinoma
Breast Ductal Carcinoma	Ductal Breast Carcinoma Duct Carcinoma Carcinoma, Ductal Mammary Ductal Carcinoma Ductal Carcinoma
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Sublingual Gland Cancer	Malignant Tumor Of Sublingual Gland Malignant Tumor Of The Sublingual Gland
Basaloid Squamous Cell Carcinoma	Basaloid Carcinoma
Breast Metaplastic Carcinoma	Metaplastic Carcinoma Of The Breast Metaplastic Breast Carcinoma Metaplastic Carcinoma Of Breast Metaplastic Breast Cancer
Lipoadenoma
Sebaceous Adenocarcinoma	Sebaceous Carcinoma Adenocarcinoma Of The Sebaceous Gland Malignant Neoplasm Of Sebaceous Gland Malignant Sebaceous Tumor Adenocarcinoma, Sebaceous Malignant Sebaceous Neoplasm Sebaceous Gland Neoplasms
Breast Myoepithelial Neoplasm	Breast Myoepithelial Tumor Malignant Breast Myoepithelioma
Breast Adenomyoepithelioma	Adenomyoepithelioma Of The Breast Breast Adenomyoepithelioma With Malignant Change Malignant Adenomyoepithelioma Of Breast
Hidradenitis Suppurativa	Acne Inversa Suppurative Hidradenitis Acne Inversa, Familial Apocrinitis Hidradenitides, Suppurative Hidradenitis, Suppurative Suppurative Hidradenitides Inverse Acne
Epithelial-Myoepithelial Carcinoma	Clear Cell Adenoma Adenomyo-Epithelioma Clear Cell Carcinoma Emc Epithelial Myoepithelial Carcinoma Glycogen-Rich Adenocarcinoma Glycogen-Rich Adenoma Monomorphic Clear Cell Tumor Tubular Solid Adenoma Adenocarcinoma, Clear Cell
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Eccrine Papillary Adenoma	Papillary Eccrine Adenoma Eccrine Papillary Adenoma Of Skin
Glycogen-Rich Carcinoma	Doid:0081028
Reticulate Acropigmentation Of Kitamura	RAK Acropigmentatio Reticularis Reticulate Pigmentation Of Kitamura Rpk Kitamura Reticulate Acropigmentation Rapk
Intraductal Breast Benign Neoplasm
Salivary Gland Carcinoma	Salivary Gland Cancer Malignant Neoplasm Of Salivary Gland Salivary Gland Neoplasms
Sweat Gland Benign Neoplasm	Neoplasm Of Sweat Gland Sweat Gland Tumor Tumor Of The Sweat Gland Sweat Gland Neoplasms Sweat Gland Neoplasm
Myoepithelial Carcinoma	Malignant Myoepithelioma Myoepithelioma Carcinoma
Corneal Dystrophy
Ulcerative Blepharitis
Recessive Dystrophic Epidermolysis Bullosa	Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type Rdeb, Hallopeau-Siemens Type Severe Generalized Rdeb Severe Generalized Recessive Dystrophic Epidermolysis Bullosa Rdeb Generalisata Gravis Rdeb, Severe Generalized Rdeb-Sev Gen Recessive Dystrophic Epidermolysis Bullosa, Severe Generalized Hallopeau-Siemens Disease
Large Cell Acanthoma
Hair Follicle Neoplasm	Hair Matrix Neoplasm Hair Matrix Tumour
Thyroid Hurthle Cell Adenoma	Benign Oncocytoma Of The Thyroid Thyroid Gland Oncocytic Adenoma
Bullous Skin Disease	Skin Diseases Bullous Skin Diseases, Bullous
Proliferative Type Fibrocystic Change Of Breast	Fibrocystic Change, Proliferative Type With Atypia Fibrocystic Disease, Proliferative Type With Atypia Proliferating Lesion Of Breast Without Atypia Proliferating Lesion Of The Breast Without Atypia Proliferative Fibrocystic Change Breast Fibrocystic Change, Proliferative Type
Sweat Gland Disease	Sweat Gland Diseases
Psoriasis
Intraductal Papilloma	Papilloma, Intraductal Ductal Papilloma Papilloma Intraductal
Squamous Cell Bile Duct Carcinoma	Bile Duct Squamous Cell Carcinoma
Comedo Carcinoma	Comedocarcinoma High Grade Ductal Breast Carcinoma In Situ
Lipid-Rich Carcinoma
Thoracic Benign Neoplasm	Benign Neoplasm Of Thorax
Breast Benign Neoplasm	Benign Tumour Of Breast Benign Neoplasm Of Female Breast
Epidermolysis Bullosa Dystrophica	Dystrophic Epidermolysis Bullosa Deb Dermolytic Epidermolysis Bullosa Epidermolysis Bullosa, Dermolytic Epidermolysis Bullosa, Dystrophic Epidermolysis Bullosa Dystrophic Dystrophic Eb - [Epidermolysis Bullosa]
Nodular Hidradenoma	Eccrine Nodular Hidradenoma Eccrine Acrospiroma
Pre-Malignant Neoplasm
Breast Carcinoma In Situ	Carcinoma In Situ Of Breast Non-Infiltrating Carcinoma Of Breast Breast Cancer In Situ
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Sebaceous Adenoma	Adenoma Of The Sebaceous Gland Skin Appendage Sebaceous Adenoma
Cervical Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Cervix Uteri Squamous Cell Carcinoma Of Cervix
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2
Ductal Carcinoma In Situ	Noninfiltrating Intraductal Carcinoma
Borst-Jadassohn Intraepidermal Carcinoma	Intraepidermal Epithelioma Of Jadassohn Bowen'S Disease, Clonal
Apocrine Adenocarcinoma	Apocrine Carcinoma Apocrine Gland Carcinoma Carcinoma Of The Apocrine Gland Carcinoma Of Apocrine Gland
Palmoplantar Keratoderma, Epidermolytic	Epidermolytic Palmoplantar Keratoderma EPPK Keratosis Palmaris Et Plantaris Familiaris Tylosis Keratosis Of Greither Diffuse Nonepidermolytic Palmoplantar Keratoderma Keratoderma, Palmoplantar, Epidermolytic Unna-Thost Palmoplantar Keratoderma Epidermolytic Palmoplantar Keratoderma Of Voerner Ppke Keratoderma, Epidermolytic Palmoplantar Palmoplantar Keratoderma, Vorner Type Hyperkeratosis, Localized Epidermolytic Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type Epidermolytic Palmoplantar Keratoderma Of Vörner Hyperkeratosis Palmoplantar Localized Epidermolytic Diffuse Neppk Ppk Diffusa Circumscripta Thost-Unna Disease Thost-Unna Palmoplantar Keratoderma Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type Epidermolytic Palmoplantar Keratoderma Of Vorner Ehppk Epidermolytic Unna-Thost Disease Localized Epidermolytic Hyperkeratosis Palmoplantar Keratoderma Vorner Type Unilateral Palmoplantar Verrucous Nevus UPVN Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Palmoplantar Keratoderma, Nonepidermolytic Epidermolytic Palmoplantar Keratoderma Vorner Type Type B Tylosis Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Type A Tylosis
Apocrine Sweat Gland Neoplasm	Apocrine Tumor Apocrine Neoplasm
Osteogenesis Imperfecta, Type Xi	Osteogenesis Imperfecta Type 11 OI11 Osteogenesis Imperfecta Type Xi Oi, Type Xi Osteogenesis Imperfecta 11 Oi Type Xi Oi-Xi
Epidermolysis Bullosa, Junctional 5b, With Pyloric Atresia	Junctional Epidermolysis Bullosa With Pyloric Atresia Carmi Syndrome Epidermolysis Bullosa, Junctional, With Pyloric Atresia Jeb-Pa JEB5B Epidermolysis Bullosa Junctionalis With Pyloric Atresia Aplasia Cutis Congenita With Gastrointestinal Atresia Epidermolysis Bullosa, Junctional, With Pyloric Atresia And Aplasia Cutis Congenita Eb-Pa-Acc Junctional Epidermolysis Bullosa-Pyloric Atresia Syndrome Jeb With Pyloric Atresia Epidermolysis Bullosa Letalis, With Pyloric Atresia Pa-Jeb Epidermolysis Bullosa With Pyloric Atresia
Rete Ovarii Benign Neoplasm
Rete Ovarii Adenoma	Adenoma Of Rete Ovarii
Polyp Of Corpus Uteri	Endometrial/Uterine Polyp Polyp Of Endometrium Polyp Of The Uterus Polyp, Uterus
Trochlear Nerve Disease	Trochlear Nerve Diseases Disorder Of Trochlear Nerve Superior Oblique Muscle Innervation Disorder Trochlear Nerve Disorder Fourth Cranial Nerve Paresis
Verrucous Carcinoma	Verrucous Squamous Carcinoma Verrucous Squamous Cell Carcinoma Warty Carcinoma Carcinoma Verrucous Carcinoma, Verrucous
In Situ Carcinoma	Carcinoma In Situ
Wrinkly Skin Syndrome	WSS Wrinkled Skin Syndrome
Sebaceous Gland Neoplasm	Sebaceous Gland Neoplasms Sebaceous Neoplasm
Tonsil Cancer	Tonsillar Neoplasms Malignant Neoplasm Of Faucial Tonsil Malignant Neoplasm Of Palatine Tonsil Malignant Neoplasm Of Tonsil, Faucial Malignant Tonsillar Tumor Malignant Tumor Of Tonsil Tonsillar Carcinoma Malignant Neoplasm Tonsil
Female Breast Cancer	Female Breast Carcinoma Carcinoma Of Female Breast Mammary Carcinoma Of Female Breast Malignant Neoplasm Of Female Breast
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Dowling-Degos Disease	Reticular Pigment Anomaly Of Flexures Dark Dot Disease Reticulate Acropigmentation Of Kitamura Dowling-Degos Kitamura Disease Kitamura Reticulate Acropigmentation Ddd Dowling-Degos-Kitamura Disease Reticular Pigmented Anomaly Of Flexures
Pilomatrixoma	Pilomatricoma PTR Epithelioma Calcificans Of Malherbe Benign Pilomatricoma Calcifying Epithelioma Of Malherbe Pilomatricoma, Somatic Benign Pilomatrixoma Malherbe Calcifying Epithelioma
Breast Lobular Carcinoma	Cancer, Breast, Lobular Lobular Breast Carcinoma
Tibial Adamantinoma	Tibial Adamantinoma Morphology
White Sponge Nevus 1	White Sponge Nevus Of Cannon Leukokeratosis, Hereditary Mucosal Hereditary Mucosal Leukokeratosis White Sponge Nevus WSN1 Wsn Cannon'S Disease Familial White Folded Mucosal Dysplasia Hereditary Leukokeratosis Hereditary Oral Keratosis Leukokeratosis Of Oral Mucosa Nevus Of Cannon White Folded Gingivostomatosis White Gingivostomatitis White Sponge Naevus White Sponge Nevus Of Mucosa
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev
Benign Peritoneal Mesothelioma	Mesothelioma Of Peritoneum Benign Neoplasm Of Mesothelial Tissue Of Peritoneum
Junctional Epidermolysis Bullosa Non-Herlitz Type	Junctional Epidermolysis Bullosa, Non-Herlitz Type Gabeb Generalized Atrophic Benign Epidermolysis Bullosa Generalized Junctional Epidermolysis Bullosa, Non-Herlitz Type Jeb-Nh Gen Jen-Nh Junctional Epidermolysis Bullosa Generalisata Mitis Junctional Epidermolysis Bullosa, Disentis Type Epidermolysis Bullosa, Junctional, Non-Herlitz Type
Sarcoma, Synovial	Synovial Sarcoma Synovialosarcoma Synovial Cell Sarcoma Sarcoma Synovial
Actinic Keratosis	Solar Keratosis Actinic Keratosis Senile Hyperkeratosis Sk - Solar Keratosis Keratosis, Actinic Seborrheic Keratosis Ak - [Actinic Keratosis] Sk - [Solar Keratosis]
Ichthyosis, Congenital, Autosomal Recessive 4a	Ichthyosis Congenita Iib Icr2b Autosomal Recessive Congenital Ichthyosis 4a ARCI4A Lamellar Ichthyosis 2 Li2 Ichthyosis, Lamellar, 2, Formerly Li2, Formerly Ichthyosis Lamellar 2 Lamellar Ichthyosis, Type 2 Ichthyosis, Lamellar 2 Ichthyosis, Congenital, Autosomal Recessive, Type 4a
Cystic Basal Cell Carcinoma	Skin Cystic Basal Cell Carcinoma
Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant	Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans KFSD
Hard Palate Cancer	Malignant Neoplasm Of Hard Palate Malignant Tumor Of Hard Palate Malignant Tumour Of Hard Palate
Skin Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Skin Epidermoid Skin Carcinoma Squamous Cell Carcinoma Of The Skin Squamous Cell Epithelioma Of Skin Cutaneous Squamous Cell Carcinoma Scc - [Squamous Cell Carcinoma] Of Skin
Oropharynx Cancer	Oropharyngeal Cancer Oropharyngeal Carcinoma Malignant Neoplasm Of Oropharynx Malignant Oropharyngeal Tumor Malignant Tumor Of Oropharynx Malignant Tumour Of Mesopharynx Oropharyngeal Cancer, Adult Cancer Of The Oropharynx
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Micronodular Basal Cell Carcinoma	Skin Micronodular Basal Cell Carcinoma Basal Cell Carcinoma, Micronodular
Transient Bullous Dermolysis Of The Newborn	TBDN Transient Bullous Of The Newborn Epidermolysis Bullosa Dystrophica, Neonatal Form Dystrophic Epidermolysis Bullosa, Neonatal Deb, Bullous Dermolysis Of The Newborn Deb-Bdn Epidermolysis Bullosa Dystrophica, Dominant Neonatal Form Self-Improving Dystrophic Epidermolysis Bullosa Self-Improving Deb Epidermolysis Bullosa Dystrophica Dominant Neonatal Type
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3	Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like Scd-Eds EDSSPD3 Ehlers-Danlos Syndrome Spondylodysplastic Type 3 Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome Slc39a13-Related Speds Slc39a13-Related Spondylodysplastic Eds Spondylocheirodysplastic Ehlers-Danlos Syndrome Speds-Slc39a13 Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Hair Disease	Hair Diseases Hair Anomaly Hair Disorder Hair Problems
Salpingitis Isthmica Nodosa
Clear Cell Basal Cell Carcinoma	Skin Clear Cell Basal Cell Carcinoma
Integumentary System Disease
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Laryngeal Small Cell Carcinoma	Small Cell Carcinoma Of Larynx
Synchronous Bilateral Breast Carcinoma
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Esophageal Adenosquamous Carcinoma
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-179587	1,2,3-Triazole-PEG8-amine		/	Unkown
HY-179588	PROTAC BET Degrader-14		/	Unkown
HY-179589	JQ-1 (carboxylic acid)-amine-PEG8-cyanogen	Degrader	/	Unkown
HY-RS07437	KRT14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19703	Krt14 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26198	Krt14 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KRT14	RGD	RGD:1307463
Bos taurus	KRT14	VGNC	VGNC:50205
Canis familiaris	KRT14	VGNC	VGNC:55620
Mus musculus	KRT14	MGD	MGI:96688
Others	KRT14	NCBI