CTTNBP2 - cortactin binding protein 2 Gene

Also Known as Orf4; C7orf8; CORTBP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83992

About CTTNBP2

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:117,710,651-117,873,441 (from NCBI)

This gene has 12 transcripts (splice variants), 218 orthologues and 4 paralogues. Broad expression in brain (RPKM 5.1), esophagus (RPKM 3.1) and 19 other tissues.

Summary

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin Cytoskeleton. [provided by RefSeq, Jul 2008]

CTTNBP2 Products (4)

mRNA Protein Name
NM_001363349.1 NP_001350278.1 cortactin-binding protein 2 isoform 2
NM_001363350.1 NP_001350279.1 cortactin-binding protein 2 isoform 3
NM_001363351.1 NP_001350280.1 cortactin-binding protein 2 isoform 3
NM_033427.3 NP_219499.1 cortactin-binding protein 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTTNBP2 Protein Structure

CortBP2

CortBP2: Cortactin-binding protein-2 (27 - 138)

CortBP2

CortBP2: Cortactin-binding protein-2 (136 - 181)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (714 - 804)

Ank

Ank: Ankyrin repeat (810 - 840)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1663 a.a.
Protein Preferred Names Protein Names

cortactin-binding protein 2

  • CORTBP2, C7orf8

CTTNBP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CTTNBP2 Q8WZ74 BMAL2 Homo sapiens Q8WYA1-3
Y2H Prey Pooling
32296183
Intra
CTTNBP2 Q8WZ74 BMAL2 Homo sapiens Q8WYA1-3
Y2H Array
32296183
Intra
CTTNBP2 Q8WZ74 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Prey Pooling
32296183
Intra
CTTNBP2 Q8WZ74 FAM86C1P Homo sapiens Q9NVL1-2
Validated Y2H
32296183
Intra
CTTNBP2 Q8WZ74 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Array
32296183
Intra
CTTNBP2 Q8WZ74 MEI4 Homo sapiens A8MW99
Y2H Array
32296183
Intra
CTTNBP2 Q8WZ74 MEI4 Homo sapiens A8MW99
Y2H Prey Pooling
32296183
Intra
CTTNBP2 Q8WZ74 PKNOX2 Homo sapiens Q96KN3
Y2H Prey Pooling
32296183
Intra
CTTNBP2 Q8WZ74 PKNOX2 Homo sapiens Q96KN3
Y2H Array
32296183
Intra
CTTNBP2 Q8WZ74 PKNOX2 Homo sapiens Q96KN3
Validated Y2H
32296183
Intra
CTTNBP2 Q8WZ74 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
CTTNBP2 Q8WZ74 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
CTTNBP2 Q8WZ74 KRT14 Homo sapiens P02533
Y2H Prey Pooling
32296183
Intra
CTTNBP2 Q8WZ74 KRT14 Homo sapiens P02533
Y2H Array
32296183
Intra
CTTNBP2 Q8WZ74 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
CTTNBP2 Q8WZ74 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
CTTNBP2 Q8WZ74 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
Intra
CTTNBP2 Q8WZ74 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 12

  • NS12
Brachial Plexus Neuritis

  • Brachial Neuritis

  • Parsonage-Aldren-Turner Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03351 CTTNBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03352 CTTNBP2NL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CTTNBP2 VGNC VGNC:71409
Canis familiaris CTTNBP2 VGNC VGNC:39719
Bos taurus CTTNBP2 VGNC VGNC:27822
Rattus norvegicus CTTNBP2 RGD RGD:628691
Mus musculus CTTNBP2 MGD MGI:1353467
Felis catus CTTNBP2 VGNC VGNC:78436
Others CTTNBP2 NCBI