PKNOX2 - PBX/knotted 1 homeobox 2 Gene

Also Known as PREP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63876

About PKNOX2

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,164,751-125,433,389 (from NCBI)

This gene has 14 transcripts (splice variants), 217 orthologues and 12 paralogues. Broad expression in thyroid (RPKM 4.8), ovary (RPKM 4.1) and 21 other tissues.

Summary

Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]

PKNOX2 Products (19)

mRNA Protein Name
NM_001382323.2 NP_001369252.1 homeobox protein PKNOX2 isoform a
NM_001382324.1 NP_001369253.1 homeobox protein PKNOX2 isoform a
NM_001382325.1 NP_001369254.1 homeobox protein PKNOX2 isoform a
NM_001382326.1 NP_001369255.1 homeobox protein PKNOX2 isoform a
NM_001382327.1 NP_001369256.1 homeobox protein PKNOX2 isoform a
NM_001382328.1 NP_001369257.1 homeobox protein PKNOX2 isoform a
NM_001382329.1 NP_001369258.1 homeobox protein PKNOX2 isoform b
NM_001382330.1 NP_001369259.1 homeobox protein PKNOX2 isoform b
NM_001382331.1 NP_001369260.1 homeobox protein PKNOX2 isoform b
NM_001382332.1 NP_001369261.1 homeobox protein PKNOX2 isoform b
NM_001382333.1 NP_001369262.1 homeobox protein PKNOX2 isoform b
NM_001382334.1 NP_001369263.1 homeobox protein PKNOX2 isoform c
NM_001382335.1 NP_001369264.1 homeobox protein PKNOX2 isoform c
NM_001382336.1 NP_001369265.1 homeobox protein PKNOX2 isoform d
NM_001382337.1 NP_001369266.1 homeobox protein PKNOX2 isoform d
NM_001382338.1 NP_001369267.1 homeobox protein PKNOX2 isoform d
NM_001382339.1 NP_001369268.1 homeobox protein PKNOX2 isoform e
NM_001382340.1 NP_001369269.1 homeobox protein PKNOX2 isoform f
NM_001382341.1 NP_001369270.1 homeobox protein PKNOX2 isoform g

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKNOX2 Protein Structure

Homeobox_KN

Homeobox_KN: Homeobox KN domain (306 - 345)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

homeobox protein PKNOX2

  • PBX/knotted homeobox 2

PKNOX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PKNOX2 Q96KN3 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra
PKNOX2 Q96KN3 CTTNBP2NL Homo sapiens Q9P2B4
Validated Y2H
32296183
Intra
PKNOX2 Q96KN3 DDA1 Homo sapiens Q9BW61
Validated Y2H
32296183
Intra
PKNOX2 Q96KN3 NUP58 Homo sapiens Q9BVL2
Validated Y2H
32296183
Intra
PKNOX2 Q96KN3 PBX1 Homo sapiens P40424
Anti Tag CoIP
33961781
Intra
PKNOX2 Q96KN3 TSG101 Homo sapiens Q99816
Validated Y2H
32296183
Intra
PKNOX2 Q96KN3 TRIB3 Homo sapiens Q96RU7
Validated Y2H
32296183
Intra
PKNOX2 Q96KN3 PAAT Homo sapiens Q9H8K7
Validated Y2H
32296183
Intra
PKNOX2 Q96KN3 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
PKNOX2 Q96KN3 CSTF2T Homo sapiens Q9H0L4
Validated Y2H
32296183
Intra
PKNOX2 Q96KN3 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a

  • MLC2A

  • Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 2a

  • Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 2a
Brugada Syndrome 2

  • BRGDA2

  • Brugada Syndrome, Type 2
Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b

  • Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10610 PKNOX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PKNOX2 VGNC VGNC:44615
Felis catus PKNOX2 VGNC VGNC:64196
Bos taurus PKNOX2 VGNC VGNC:32949
Rattus norvegicus PKNOX2 RGD RGD:1590611
Macaca mulatta PKNOX2 VGNC VGNC:76037
Mus musculus PKNOX2 MGD MGI:2445415
Others PKNOX2 NCBI