PBX4 - PBX homeobox 4 Gene

Homo sapiens

Gene ID: 80714 | Gene type: protein coding

About PBX4

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,561,713-19,618,687 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 12 paralogues. Broad expression in thyroid (RPKM 3.9), testis (RPKM 2.5) and 18 other tissues.

Summary

This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

PBX4 Products(1)

mRNA	Protein	Name
NM_025245.3	NP_079521.1	pre-B-cell leukemia transcription factor 4

PBX4 Protein Structure

PBC

Homeobox

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

pre-B-cell leukemia transcription factor 4

homeobox protein PBX4

Related Diseases

Diseases

Alias

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Cantu Syndrome

Hypertrichotic Osteochondrodysplasia	Hypertrichotic Osteochondrodysplasia Cantu Type
Cantú Syndrome	Craniofaciocardioskeletal Syndrome
Hypertrichosis-Osteochondrodysplasia-Cardiomegaly Syndrome	Congenital Hypertrichosis-Acromegaloid Facial Features Spectrum
Congenital Hypertrichosis-Coarse Facial Features Spectrum	HTOCD
Osteochondrodysplasia, Hypertrichotic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10109	PBX4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PBX4	VGNC	VGNC:44289
Felis catus	PBX4	VGNC	VGNC:64057
Bos taurus	PBX4	VGNC	VGNC:32610
Rattus norvegicus	PBX4	RGD	RGD:1305100
Mus musculus	PBX4	MGD	MGI:1931321