IPO13 - importin 13 Gene

Also Known as LGL2; IMP13; KAP13; RANBP13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9670

About IPO13

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:43,946,950-43,968,022 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in testis (RPKM 29.4), brain (RPKM 19.8) and 24 other tissues.

Summary

This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]

IPO13 Products (1)

mRNA Protein Name
NM_014652.4 NP_055467.3 importin-13

IPO13 Protein Structure

IBN_N

IBN_N: Importin-beta N-terminal domain (45 - 109)

Xpo1

Xpo1: Exportin 1-like protein (117 - 262)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 963 a.a.
Protein Preferred Names Protein Names

importin-13

  • Ran binding protein 13

IPO13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IPO13 O94829 PBX4 Homo sapiens Q9BYU1 25416956
Intra
IPO13 O94829 PBX4 Homo sapiens Q9BYU1 29892012
Intra
IPO13 O94829 PBX4 Homo sapiens Q9BYU1 31515488
Intra
IPO13 O94829 PBX4 Homo sapiens Q9BYU1 32296183
Intra
IPO13 O94829 PBX4 Homo sapiens Q9BYU1 25416956
Intra
IPO13 O94829 EIF1AX Homo sapiens P47813 23435562
Intra
IPO13 O94829 EIF1AX Homo sapiens P47813
GMS
23435562
Intra
IPO13 O94829 EIF1AX Homo sapiens P47813 21139563
Intra
IPO13 O94829 PAX3 Homo sapiens P23760-8 32296183
Intra
IPO13 O94829 HMBOX1 Homo sapiens Q6NT76 32296183
Intra
IPO13 O94829 RAN Homo sapiens P62826 21139563
Intra
IPO13 O94829 RAN Homo sapiens P62826 21139563
Intra
IPO13 O94829 RAN Homo sapiens P62826 23435562
Intra
IPO13 O94829 MAGOH Homo sapiens P61326
TSA
23435562
Intra
IPO13 O94829 MAGOH Homo sapiens P61326 23435562
Intra
IPO13 O94829 MAGOH Homo sapiens P61326 21139563
Intra
IPO13 O94829 PSMA1 Homo sapiens P25786 32296183
Intra
IPO13 O94829 PITX1 Homo sapiens P78337 32296183
Intra
IPO13 O94829 UBE2I Homo sapiens P63279
TSA
23435562
Intra
IPO13 O94829 UBE2I Homo sapiens P63279 23435562
Intra
IPO13 O94829 UBE2I Homo sapiens P63279 21139563
Intra
IPO13 O94829 UBE2I Homo sapiens P63279 21139563
Cross: Cross-species interaction Intra: Intraspecies interaction

IPO13 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89596 karyopherin 13 Antibody (YA8940) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Partington Syndrome
  • X-Linked Reticulate Pigmentary Disorder

  • PRTS

  • Partington X-Linked Mental Retardation Syndrome

  • Mrxs1

  • Mrx36

  • Intellectual Developmental Disorder, X-Linked, Syndromic 1

  • Partington Disease

  • Pdr

  • Partington-Mulley Syndrome

  • Russell-Silver Syndrome, X-Linked

  • Mental Retardation, X-Linked, Syndromic 1

  • Mental Retardation, X-Linked, With Dystonic Movements, Ataxia, And Seizures

  • Mental Retardation, X-Linked 36

  • X-Linked Reticulate Pigmentary Disorder With Systemic Manifestations

  • X-Linked Russell-Silver Syndrome

  • Intelectual Disability-Dystonic Movements-Ataxia-Seizures Syndrome

  • Intellectual Disability, X-Linked, Syndromic 1

  • Intellectual Disability, X-Linked, With Dystonic Movements, Ataxia, And Seizures

  • Partington X-Linked Intellectual Disability Syndrome

  • X-Linked Intellectual Deficit-Dystonia-Dysarthria

  • X-Linked Mental Retardation With Dystonic Movements, Ataxia, And Seizures

  • Familial Cutaneous Amyloidosis

  • X-Linked Cutaneous Amyloidosis

  • Xlpdr

  • X-Linked Intellectual Disability-Dystonia-Dysarthria Syndrome

  • Pigmentary Disorder, Reticulate, With Systemic Manifestations

Corpus Callosum, Agenesis Of, With Abnormal Genitalia
  • Proud Syndrome

  • Corpus Callosum Agenesis-Abnormal Genitalia Syndrome

  • Acc With Abnormal Genitalia

  • Proud-Levine-Carpenter Syndrome

  • Microcephaly-Corpus Callosum Agenesis-Abnormal Genitalia Syndrome

  • Corpus Callosum Agenesis With Abnormal Genitalia

  • New X-Linked Syndrome With Seizures, Acquired Micrencephaly, And Agenesis Of The Corpus Callosum

  • Proud Levine Carpenter Syndrome

  • Acc-Abnormal Genitalia Syndrome

  • Agenesis Of The Corpus Callosum, With Abnormal Genitalia

  • ACCAG

  • Micrencephaly-Corpus Callosum Agenesis-Abnormal Genitalia

  • Congenital Neurologic Anomalies

Myiasis
  • Infestation By Fly Larvae

  • Infestation By Maggots

  • Maggot Infestation

  • Infestation By Larvae Of Flies

  • Infestation By Dermatobia

  • Infestation By Estrus Ovis

  • Infestation By Oestrus Ovis

  • Oestriasis

  • Oestrosis

Lissencephaly, X-Linked, 2
  • X-Linked Lissencephaly With Abnormal Genitalia

  • Hydranencephaly With Abnormal Genitalia

  • Xlag

  • Xlisg

  • X-Linked Lissencephaly With Ambiguous Genitalia

  • LISX2

  • Lissencephaly, X-Linked 2

  • X-Linked Lissencephaly 2

  • X-Linked Lissencephaly-Corpus Callosum Agenesis-Genital Anomalies Syndrome

  • Xlag Syndrome

  • Lissencephaly, X-Linked, With Ambiguous Genitalia

  • Xlis2

  • X-Linked Lissencephaly - Agenesis Of The Corpus Callosum - Genital Anomalies

  • X-Linked Lissencephaly-Agenesis Of The Corpus Callosum-Genital Anomalies Syndrome

  • Xlag Syndrome

  • Lissencephaly X-Linked With Ambiguous Genitalia

  • Lissencephaly, X-Linked, Type 2

  • Chromosome Xq26.3 Duplication Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus IPO13 MGD MGI:2385205
Rattus norvegicus IPO13 RGD RGD:620071
Canis familiaris IPO13 VGNC VGNC:42064
Bos taurus IPO13 VGNC VGNC:30241
Macaca mulatta IPO13 VGNC VGNC:73609
Felis catus IPO13 VGNC VGNC:62954
Others IPO13 NCBI