RAN - RAN, member RAS oncogene family Gene

Homo sapiens

Also known as TC4; Gsp1; ARA24

Gene ID: 5901 | Gene type: protein coding

About RAN

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,872,066-130,877,678 (from NCBI)

This gene has 12 transcripts (splice variants) and 298 orthologues. Ubiquitous expression in lymph node (RPKM 71.4), testis (RPKM 70.1) and 25 other tissues.

Summary

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the Ras superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an Androgen Receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the Androgen Receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

RAN Products(3)

mRNA	Protein	Name
NM_001300796.2	NP_001287725.1	GTP-binding nuclear protein Ran isoform 2
NM_001300797.2	NP_001287726.1	GTP-binding nuclear protein Ran isoform 2
NM_006325.5	NP_006316.1	GTP-binding nuclear protein Ran isoform 1

RAN Protein Structure

Ras

0
100
200
216 a.a.

Protein Preferred Names

Protein Names

GTP-binding nuclear protein Ran

GTPase Ran

Related Diseases

Diseases

Alias

Vici Syndrome

Absent Corpus Callosum Cataract Immunodeficiency	VICIS
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation, And Absent Corpus Callosum	Dionisi Vici Sabetta Gambarara Syndrome
Immunodeficiency With Cleft Lip/Palate, Cataract, Hypopigmentation And Absent Corpus Callosum	Corpus Callosum Agenesis-Cataract-Immunodeficiency Syndrome
Dionisi-Vici-Sabetta-Gambarara Syndrome	Immunodeficiency With Cleft Lip/Palate Cataract Hypopigmentation And Absent Corpus Callosum

Teratocarcinoma

Mixed Embryonal Carcinoma And Teratoma

X-Linked Chondrodysplasia Punctata 1

Chondrodysplasia Punctata 1, X-Linked	Arylsulfatase E Deficiency
Chondrodystrophia Calcificans Congenita	Cdpx1
X-Linked Recessive Chondrodysplasia Punctata 1	Brachytelephalangic Chondrodysplasia Punctata

Hypertrichosis Universalis Congenita, Ambras Type

Ambras Syndrome	Hypertrichosis, Congenital Generalized
HTC1	HTC2
Chromosome Xq27.1 Interchromosomal Insertion Syndrome	Cgh
Hcg	Ambras Type Hypertrichosis Universalis Congenita
X-Linked Congenital Generalized Hypertrichosis	Congenital Generalized Hypertrichosis, Macias-Flores Type
Macias Flores-Garcia Cruz-Rivera Syndrome	Htc 1
Hypertrichosis Universalis Congenita Ambras Type	Hypertrichosis Congenital Generalized X-Linked
Macias-Flores Garcia-Cruz Rivera Syndrome	Congenital Generalized Hypertrichosis, Ambras Type

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma	Anaplastic Thyroid Cancer
Thyroid Cancer, Anaplastic	Thyroid Carcinoma, Anaplastic
Thyroid Carcinoma Anaplastic

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125964	LLP-3	Inhibitor	/	Unkown
HY-RS11641	RAN Human Pre-designed siRNA Set A		/	Unkown
HY-W250191	Tergitol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAN	MGD	MGI:1333112
Canis familiaris	RAN	VGNC	VGNC:59442
Rattus norvegicus	RAN	RGD	RGD:620367
Felis catus	RAN	VGNC	VGNC:80475
Macaca fascicularis	RAN	NCBI
Susscrofa domestica	RAN	NCBI
Leporidae	RAN	NCBI
Macaca mulatta	RAN	NCBI
Others	RAN	NCBI

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