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TP53BP2 - tumor protein p53 binding protein 2 Gene

Also Known as BBP; 53BP2; ASPP2; P53BP2; PPP1R13A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7159

About TP53BP2

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:223,779,893-223,845,947 (from NCBI)

This gene has 13 transcripts (splice variants), 285 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 18.6), brain (RPKM 14.3) and 25 other tissues.

Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates Apoptosis and cell growth through interactions with Other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TP53BP2 Products (2)

mRNA	Protein	Name
NM_001031685.3	NP_001026855.2	apoptosis-stimulating of p53 protein 2 isoform 1
NM_005426.3	NP_005417.1	apoptosis-stimulating of p53 protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	10498867	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18448430	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	14985081	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8875926	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	25963096	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IDA IDA: Inferred from direct assay	11684014	GOA
involved in positive regulation of execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	14985081	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10646860	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19377511	GOA
colocalizes with perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10646860	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14985081	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53BP2 Protein Structure

Ank_2

SH3_1

0
200
400
600
800
1000
1134 a.a.

Protein Preferred Names	Protein Names
apoptosis-stimulating of p53 protein 2	BCL2-binding protein

TP53BP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TP53BP2	Q13625	APC2	Homo sapiens	O95996	Y2H	10646860
Intra	TP53BP2	Q13625	ITCH	Homo sapiens	Q96J02	Anti Bait CoIP	25436413
Intra	TP53BP2	Q13625	RAN	Homo sapiens	P62826	Far-WB	24855949
Intra	TP53BP2	Q13625	RAN	Homo sapiens	P62826	Pull Down	24855949
Intra	TP53BP2	Q13625	BCL2L1	Homo sapiens	Q07817-1	Peptide Array	18719108
Intra	TP53BP2	Q13625	BCL2L1	Homo sapiens	Q07817-1	SPR	18719108
Intra	TP53BP2	Q13625	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	TP53BP2	Q13625	PPP1CC	Homo sapiens	P36873	Anti Tag CoIP	21998301
Intra	TP53BP2	Q13625	PPP1CC	Homo sapiens	P36873	Anti Tag CoIP	24366813
Intra	TP53BP2	Q13625	PPP1CC	Homo sapiens	P36873	Anti Bait CoIP	21998301
Intra	TP53BP2	Q13625	PPP1CA	Homo sapiens	P62136	Anti Bait CoIP	21998301
Intra	TP53BP2	Q13625	PPP1CA	Homo sapiens	P62136	Y2H	22321011
Intra	TP53BP2	Q13625	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	21998301
Intra	TP53BP2	Q13625	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	24366813
Intra	TP53BP2	Q13625	PPP1CA	Homo sapiens	P62136	Y2H	15231748
Intra	TP53BP2	Q13625	TP53	Homo sapiens	P04637	Anti Bait CoIP	21513714
Intra	TP53BP2	Q13625	TP53	Homo sapiens	P04637	Y2H Array	31515488
Intra	TP53BP2	Q13625	TP53	Homo sapiens	P04637	Y2H Array	25502805
Intra	TP53BP2	Q13625	TP53	Homo sapiens	P04637	Pull Down	14985081
Intra	TP53BP2	Q13625	EP300	Homo sapiens	Q09472	Anti Bait CoIP	21513714
Intra	TP53BP2	Q13625	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	25344754
Intra	TP53BP2	Q13625	BCL2L2	Homo sapiens	Q92843	Peptide Array	18448430
Intra	TP53BP2	Q13625	BCL2L2	Homo sapiens	Q92843	Peptide Array	18719108
Intra	TP53BP2	Q13625	BCL2L2	Homo sapiens	Q92843	SPR	18719108
Intra	TP53BP2	Q13625	RELA	Homo sapiens	Q04206	Peptide Array	18448430
Intra	TP53BP2	Q13625	RELA	Homo sapiens	Q04206	Fluorescence	18448430
Intra	TP53BP2	Q13625	APP	Homo sapiens	P05067	Y2H	11278849
Intra	TP53BP2	Q13625	BCL2	Homo sapiens	P10415	Peptide Array	18719108
Intra	TP53BP2	Q13625	BCL2	Homo sapiens	P10415	SPR	18719108
Intra	TP53BP2	Q13625	BCL2	Homo sapiens	P10415	Fluorescence	18719108
Intra	TP53BP2	Q13625	BCL2	Homo sapiens	P10415	PLA	18719108
Cross	TP53BP2	Q13625	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Anti Tag CoIP	14985081
Cross	TP53BP2	Q13625	P27958-PRO_0000037566	Hepatitis C virus	P27958-PRO_0000037566	Pull Down	14985081

Cross: Cross-species interaction Intra: Intraspecies interaction

TP53BP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82831	TP53BP2 Antibody (YA2576)	WB, IHC-P, ICC/IF	Human
HY-P86277	TP53BP2 Antibod (YA5969)	WB, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Chromosome 1q41-Q42 Deletion Syndrome	1q41-Q42 Microdeletion Syndrome 1q41q42 Microdeletion Syndrome Holoprosencephaly 10, Included Hpe10, Included 1q41-Q42 Deletion Syndrome Deletion 1q41-Q42 Monosomy 1q41-Q42 Del(1)(Q41q42) Monosomy 1q41q42 Chromosome Deletion Syndrome 1q41-Q42 Holoprosencephaly 10
Large Intestine Adenocarcinoma	Adenocarcinoma Of Large Intestine
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14916	TP53BP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TP53BP2	VGNC	VGNC:47721
Felis catus	TP53BP2	VGNC	VGNC:66462
Mus musculus	TP53BP2	MGD	MGI:2138319
Bos taurus	TP53BP2	VGNC	VGNC:36233
Rattus norvegicus	TP53BP2	RGD	RGD:1305461
Macaca mulatta	TP53BP2	VGNC	VGNC:78629
Others	TP53BP2	NCBI