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APC2 - APC regulator of WNT signaling pathway 2 Gene

Also Known as APCL; MRT74

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10297

About APC2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,446,230-1,473,244 (from NCBI)

This gene has 8 transcripts (splice variants), 195 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in brain (RPKM 24.7) and adrenal (RPKM 1.1).

Summary

This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]

APC2 Products (2)

mRNA	Protein	Name
NM_001351273.1	NP_001338202.1	adenomatous polyposis coli protein 2 isoform 2
NM_005883.3	NP_005874.1	adenomatous polyposis coli protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IDA IDA: Inferred from direct assay	9823329	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10644998	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of GTPase activity	IMP IMP: Inferred from mutant phenotype	25753423	GOA
involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25753423	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	9823329	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	26393419	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11691822	GOA
located in actin filament	IDA IDA: Inferred from direct assay	11691822	GOA
part of catenin complex	IDA IDA: Inferred from direct assay	9823329	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11691822	GOA
colocalizes with cytoplasmic microtubule	IDA IDA: Inferred from direct assay	10644998	GOA
part of filamentous actin	IDA IDA: Inferred from direct assay	25753423	GOA
located in lamellipodium membrane	IDA IDA: Inferred from direct assay	11691822	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	10644998	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10644998	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APC2 Protein Structure

Suppressor_APC

Arm

APC_r

SAMP

APC_r

SAMP

APC_basic

0
400
800
1200
1600
2000
2303 a.a.

Protein Preferred Names	Protein Names
adenomatous polyposis coli protein 2	APC2, WNT signaling pathway regulator

APC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APC2	O95996	MAPRE1	Homo sapiens	Q15691	Pull Down	10644998
Intra	APC2	O95996	MAPRE3	Homo sapiens	Q9UPY8	Anti Tag CoIP	10644998
Intra	APC2	O95996	MAPRE3	Homo sapiens	Q9UPY8	Pull Down	10644998
Intra	APC2	O95996	MAPRE3	Homo sapiens	Q9UPY8	Y2H	10644998
Intra	APC2	O95996	TP53BP2	Homo sapiens	Q13625	Confocal	10646860
Intra	APC2	O95996	TP53BP2	Homo sapiens	Q13625	Pull Down	10646860

Cross: Cross-species interaction Intra: Intraspecies interaction

APC2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83881	APC2 Antibody (YA3578)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P83881A	APC2 Antibody (YA3578)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Cortical Dysplasia, Complex, With Other Brain Malformations 10	CDCBM10
Intellectual Developmental Disorder, Autosomal Recessive 74	MRT74 Sotos Syndrome 3, Formerly Sotos3, Formerly Autosomal Recessive Intellectual Developmental Disorder 74 Sotos3 Sotos Syndrome 3
Sotos Syndrome 3	Sotos3 Sotos Syndrome, Type 3
Sotos Syndrome	Cerebral Gigantism SOTOS Chromosome 5q35 Deletion Syndrome Sotos Syndrome 1, Formerly Sotos1, Formerly Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development Sotos Sequence Sotos' Syndrome Sotos1 Sotos Syndrome 1
Tracheoesophageal Fistula With Or Without Esophageal Atresia	Esophageal Atresia With Or Without Tracheoesophageal Fistula Esophageal Atresia
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Penile Benign Neoplasm	Neoplasm Of Penis Penile Tumor Cancer Of Penis Carcinoma Of Penis Malignant Neoplasm Of Penis, Unspecified Malignant Neoplasm Of Penis, Part Unspecified Malignant Tumour Of Penis Penile Cancer Primary Malignant Neoplasm Of Penis Malignant Neoplasm Of Skin Of Penis Nos
Paraphimosis
Male Reproductive Organ Benign Neoplasm
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Familial Adenomatous Polyposis	Adenomatous Polyposis Coli Fap Familial Polyposis Coli Familial Multiple Polyposis Syndrome Adenomatous Polyposis Of The Colon Familial Intestinal Polyposis Fpc Familial Adenomatous Polyposis Of The Colon Familial Multiple Polyposis Familial Polyposis Of The Colon Hereditary Polyposis Coli Polyposis, Adenomatous Intestinal Adenomatous Familial Polyposis Adenomatous Familial Polyposis Syndrome Myh-Associated Polyposis Colorectal Adenomatous Polyposis Adenomatous Polyposis, Familial Mutyh-Associate Polyposis
Hemoglobin E Disease	Hemoglobin E Hb-E Disease
Phimosis	Tight Foreskin Tight Frenulum Congenital Phimosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119331	CFM-5	Inducer	99.48%	Unkown
HY-103255	CFM-4	Inducer	98.85%	Unkown
HY-116473	CFM-1	Antagonist	/	Unkown
HY-153538	AP-C2	Inhibitor	99.42%	Unkown
HY-RS00680	ANAPC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00810	APC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13104	SLC25A23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	APC2	VGNC	VGNC:26006
Felis catus	APC2	VGNC	VGNC:102000
Rattus norvegicus	APC2	RGD	RGD:1308256
Canis familiaris	APC2	VGNC	VGNC:54573
Macaca mulatta	APC2	VGNC	VGNC:69888
Mus musculus	APC2	MGD	MGI:1346052
Others	APC2	NCBI