TP53BP2 Antibod (YA5969)
(Synonyms: TP53BP2; ASPP2; BBP; Apoptosis-stimulating of p53 protein 2 ; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2; )
Based on 1 Customer Validation
TP53BP2 Antibody (YA5969) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TP53BP2.
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Host:
Rabbit
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Isotype:
IgG/Kappa
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-5000 | 1:100-300 | 1:100-300 |
Product Details
TP53BP2 Antibody (YA5969) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TP53BP2.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 124 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Protein A
Non-conjugated
Unmodified
IgG/Kappa
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TP53BP2 Antibod is a Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42[1].
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Subcellular Localization
Cytoplasm, perinuclear region; Nucleus
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Expression
Tissue_specificity:Widely expressed. It is expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon, and peripheral blood leukocytes. Expression is reduced in breast cancer cells expressing wild-type TP53 protein. It is overexpressed in lung cancer cell lines.
Induction:Following DNA damage induced by UV irradiation. Down-regulated by wild-type, but not mutant, p53/TP53 -
Isoforms & Post-Translational Modification
Q13625 has 3 isomers: Q13625-1: 125616 Da (predicted); Q13625-2: 111431 Da (predicted); Q13625-3: 126323 Da (predicted).
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Subunit
Interacts with P53/TP53; the interaction promotes pro-apoptotic activity (PubMed:11684014, PubMed:12524540, PubMed:8016121). Interacts with BCL2 (PubMed:8668206). Interacts with protein phosphatase 1. Interacts with RELA NF-kappa-B subunit. This interaction probably prevents the activation of apoptosis, possibly by preventing its interaction with TP53. Interacts with APC2 and NAE1. Interacts with DDX42 (via the C-terminus); the interaction is not inhibited by TP53BP2 ubiquitination and is independent of p53/TP53
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SwissProt ID
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Synonyms
TP53BP2; ASPP2; BBP; Apoptosis-stimulating of p53 protein 2 ; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2; 53BP2; p53-binding protein 2; p53BP2;
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