PPP1R11 - protein phosphatase 1 regulatory inhibitor subunit 11 Gene

Also Known as HCGV; IPP3; HCG-V; TCTE5; TCTEX5; CFAP255

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6992

About PPP1R11

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,061,265-30,070,333 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele and 184 orthologues. Ubiquitous expression in small intestine (RPKM 46.4), thyroid (RPKM 45.6) and 25 other tissues.

Summary

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

PPP1R11 Products (1)

mRNA Protein Name
NM_021959.3 NP_068778.1 E3 ubiquitin-protein ligase PPP1R11

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphatase binding EXP
EXP: Inferred from Experiment
9843442 GOA
enables phosphatase binding IPI
IPI: Inferred from physical interaction
9843442 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9843442 GOA
enables protein phosphatase inhibitor activity IDA
IDA: Inferred from direct assay
9843442 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
27805901 GOA
Biological Process GO Annotation Evidence References Source
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
27805901 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R11 Protein Structure

PPI_Ypi1

PPI_Ypi1: Protein phosphatase inhibitor (33 - 81)

  • 0
  • 100
  • 126 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase PPP1R11

  • HCG V

PPP1R11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP1R11 O60927 YAF2 Homo sapiens Q8IY57-5
Validated Y2H
32296183
Intra
PPP1R11 O60927 YAF2 Homo sapiens Q8IY57-5
Y2H Prey Pooling
32296183
Intra
PPP1R11 O60927 YAF2 Homo sapiens Q8IY57-5
Y2H Array
32296183
Intra
PPP1R11 O60927 CLSTN1 Homo sapiens O94985-2
Validated Y2H
32814053
Intra
PPP1R11 O60927 CLSTN1 Homo sapiens O94985-2
Y2H Array
32814053
Intra
PPP1R11 O60927 CLSTN1 Homo sapiens O94985-2
Y2H Pooling
32814053
Intra
PPP1R11 O60927 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
PPP1R11 O60927 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
PPP1R11 O60927 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
PPP1R11 O60927 PPP1CB Homo sapiens P62140
Y2H Array
32296183
Intra
PPP1R11 O60927 PPP1CB Homo sapiens P62140
Y2H Prey Pooling
32296183
Intra
PPP1R11 O60927 PPP1CB Homo sapiens P62140
Validated Y2H
32296183
Intra
PPP1R11 O60927 PPP1CC Homo sapiens P36873
Y2H Prey Pooling
32296183
Intra
PPP1R11 O60927 PPP1CC Homo sapiens P36873
Validated Y2H
32296183
Intra
PPP1R11 O60927 PPP1CC Homo sapiens P36873
Y2H Array
32296183
Intra
PPP1R11 O60927 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
PPP1R11 O60927 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
PPP1R11 O60927 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
PPP1R11 O60927 IFT20 Homo sapiens Q8IY31-3
Y2H Array
32296183
Intra
PPP1R11 O60927 IFT20 Homo sapiens Q8IY31-3
Validated Y2H
32296183
Intra
PPP1R11 O60927 IFT20 Homo sapiens Q8IY31-3
Y2H Prey Pooling
32296183
Cross
PPP1R11 O60927 PPP1CA Oryctolagus cuniculus P62139
Affinity Chrom
9843442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10977 PPP1R11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PPP1R11 MGD MGI:1923747
Canis familiaris PPP1R11 VGNC VGNC:44877
Bos taurus PPP1R11 VGNC VGNC:33222
Macaca mulatta PPP1R11 VGNC VGNC:82209
Rattus norvegicus PPP1R11 RGD RGD:1303163
Others PPP1R11 NCBI