DPYSL5 - dihydropyrimidinase like 5 Gene

Also Known as CV2; CRAM; CRMP5; RTSC4; Ulip6; CRMP-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56896

About DPYSL5

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,847,995-26,950,351 (from NCBI)

This gene has 7 transcripts (splice variants), 255 orthologues, 5 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 10.7), testis (RPKM 2.0) and 1 other tissue.

Summary

This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

DPYSL5 Products (3)

mRNA	Protein	Name
NM_001253723.2	NP_001240652.1	dihydropyrimidinase-related protein 5
NM_001253724.2	NP_001240653.1	dihydropyrimidinase-related protein 5
NM_020134.4	NP_064519.2	dihydropyrimidinase-related protein 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	33894126	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPYSL5 Protein Structure

Amidohydro_1

0
100
200
300
400
500
564 a.a.

Protein Preferred Names	Protein Names
dihydropyrimidinase-related protein 5	CRMP3-associated molecule

DPYSL5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DPYSL5	Q9BPU6	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Anti Tag CoIP	33961781
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Anti Tag CoIP	28514442
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Y2H Array	25416956
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Y2H Array	32296183
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Y2H Array	29892012
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Y2H Prey Pooling	32296183
Intra	DPYSL5	Q9BPU6	DPYSL2	Homo sapiens	Q16555	Y2H Array	31515488
Intra	DPYSL5	Q9BPU6	CFAP161	Homo sapiens	Q6P656	Y2H Array	32296183
Intra	DPYSL5	Q9BPU6	CFAP161	Homo sapiens	Q6P656	Y2H Prey Pooling	32296183
Intra	DPYSL5	Q9BPU6	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	HIP1	Homo sapiens	O00291	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	HIP1	Homo sapiens	O00291	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	HIP1	Homo sapiens	O00291	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	COQ8A	Homo sapiens	Q8NI60	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	COQ8A	Homo sapiens	Q8NI60	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	COQ8A	Homo sapiens	Q8NI60	Y2H Pooling	32814053
Intra	DPYSL5	Q9BPU6	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	DPYSL5	Q9BPU6	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	DPYSL5	Q9BPU6	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

DPYSL5 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82752	CRMP5 Antibody (YA2497)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ritscher-Schinzel Syndrome 4	RTSC4
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Thymoma	Primary Thymic Epithelial Neoplasm Primary Thymic Epithelial Tumor Thymus Neoplasms
Ritscher-Schinzel Syndrome	3c Syndrome Ccc Dysplasia Craniocerebellocardiac Dysplasia Cranio-Cerebello-Cardiac Dysplasia
Optic Neuritis	Inflammatory Optic Neuropathy
Chorea Gravidarum
Anal Spasm	Proctospasm Anorectal Spasm Rectal Spasm
Vascular Myelopathy	Vascular Myelopathies
Choroid Plexus Meningioma	Choroid Meningioma Meningioma Of The Choroid Plexus
Neuroretinitis	Juxtapapillary Focal Retinitis And Retinochoroiditis Retinitis Focal Retinitis And Retinochoroiditis, Juxtapapillary Papilloretinitis
Autoimmune Optic Neuritis
Autoimmune Epilepsy
Transverse Myelitis	Myelitis Transverse Myelitis, Transverse
Nutritional Optic Neuropathy
Cerebellopontine Angle Meningioma	Meningioma Of The Cerebellar Pontine Angle
Polyradiculopathy
La Crosse Encephalitis	California Encephalitis California Virus Encephalitis Neuroinvasive California Encephalitis Virus Infection Californian Encephalitis Encephalitis, California California Meningoencephalitis California Encephalitis Virus Infection California Encephalitis Virus Infection Neuroinvasive Disease California Meningoencephalitis Virus Disease California Serogroup Virus Neuroinvasive Disease California Viral Encephalitis Ce - [California Encephalitis] Lac - [La Crosse Encephalitis]
Autoimmune Disease Of Peripheral Nervous System
Thymus Gland Disease	Disease Of Thymus Gland
Neuritis	Peripheral Neuritis
Limbic Encephalitis
Thymus Cancer	Thymic Neoplasm Thymic Tumor Thymus Neoplasm Thymus Neoplasms Malignant Neoplasm Of Thymus Neoplasm Of Thymus Thymic Neoplasms Thymoma, Familial Thymic Carcinoma Thymoma, Type C Cancer Of Thymus Malignant Tumour Of Thymus Primary Malignant Neoplasm Of Thymus Thymic Glandular Cancer Thymus Gland Cancer
Choreatic Disease	Chorea Hereditary Chorea
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Neurosarcoidosis	Cerebral Sarcoidosis
Plexopathy
Stiff-Person Syndrome	SPS Stiff-Man Syndrome Stiff Man Syndrome Stiff Person Syndrome Moersch-Woltman Syndrome Sms Stiff-Trunk Syndrome Morsch Woltman Syndrome Stiff Person Syndrome And Related Disorders Stiff Person Spectrum Disorder Classic Stiff Person Syndrome Classic Sps Focal Stiff Limb Syndrome Focal Stiff-Person Syndrome Stiff Leg Syndrome Progressive Encephalomyelitis With Rigidity
Acute Disseminated Encephalomyelitis	Acute Disseminated Encephalitis Adem Ade Encephalomyelitis Acute Disseminated Encephalomyelitis, Acute Disseminated Adem - [Acute Disseminated Encephalomyelitis]
Optic Papillitis	Papillitis Papilledema
Anterograde Amnesia	Amnesia, Anterograde
Ritscher-Schinzel Syndrome 2	RTSC2
Brain Meningioma	Intracranial Meningioma
Mononeuritis Multiplex
Lingual-Facial-Buccal Dyskinesia	Orofacial Dyskinesia Oro-Facial Dyskinesia Dyskinesias
Neuromuscular Junction Disease	Neuromuscular Junction Diseases
Mononeuritis Of Upper Limb And Mononeuritis Multiplex
Myelitis	Spinal Cord Inflammation Nos Radiculomyelitis Nos Myeloradiculitis
Autoimmune Neuropathy
Whipple Disease	Intestinal Lipodystrophy Whipple'S Disease Intestinal Lipophagic Granulomatosis Secondary Non-Tropical Sprue Tropheryma Whippelii Infection Whipples Disease
Cranial Nerve Disease	Cranial Nerve Disorder Disorder Of Cranial Nerve Cranial Nerve Diseases
Optic Nerve Disease	Optic Neuropathy Disorder Of The Second Nerve Optic Nerve Disorder Optic Nerve Abnormality Of The Optic Nerve Optic Nerve Disorders Neuropathy, Optic Disorder Of The Optic Nerve
Mutism
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome
Spinal Cord Disease	Spinal Cord Diseases Myelopathy Bone Marrow Diseases
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Movement Disease	Movement Disorders Movement Disorder
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03984	DPYSL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DPYSL5	MGD	MGI:1929772
Rattus norvegicus	DPYSL5	RGD	RGD:620467
Canis familiaris	DPYSL5	VGNC	VGNC:40085
Bos taurus	DPYSL5	VGNC	VGNC:28198
Macaca mulatta	DPYSL5	VGNC	VGNC:71872
Felis catus	DPYSL5	VGNC	VGNC:61618
Others	DPYSL5	NCBI