XPO7 - exportin 7 Gene

Also Known as EXP7; RANBP16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23039

About XPO7

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:21,919,662-22,006,585 (from NCBI)

This gene has 9 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 19.6), thyroid (RPKM 15.0) and 25 other tissues.

Summary

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic Amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

XPO7 Products (3)

mRNA	Protein	Name
NM_001100161.2	NP_001093631.1	exportin-7 isoform a
NM_001362802.2	NP_001349731.1	exportin-7 isoform d
NM_015024.5	NP_055839.3	exportin-7 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear export signal receptor activity	IDA IDA: Inferred from direct assay	11024021	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	11024021	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11071879	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	11024021	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11071879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPO7 Protein Structure

IBN_N

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200
400
600
800
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1087 a.a.

Protein Preferred Names	Protein Names
exportin-7	RAN binding protein 16

XPO7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XPO7	Q9UIA9	RAN	Homo sapiens	P62826	Y2H Prey Pooling	32296183
Intra	XPO7	Q9UIA9	RAN	Homo sapiens	P62826	Y2H Array	32296183
Intra	XPO7	Q9UIA9	USO1	Homo sapiens	O60763	Validated Y2H	25416956
Intra	XPO7	Q9UIA9	USO1	Homo sapiens	O60763	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Arts Syndrome	ARTS Mrxsarts Ataxia, Fatal X-Linked, With Deafness And Loss Of Vision Mrxs18 Lethal Ataxia With Deafness And Optic Atrophy Fatal X-Linked Ataxia With Deafness And Loss Of Vision Mental Retardation, X-Linked, Syndromic, Arts Type Mental Retardation, X-Linked, Syndromic 18 Syndromic X-Linked Mental Retardation 18 Syndromic X-Linked Mental Retardation Arts Type Lethal Ataxia-Deafness-Optic Atrophy X-Linked Fatal Ataxia With Deafness And Loss Of Vision Ataxia-Deafness-Optic Atrophy, Lethal Lethal Ataxia With Hearing Loss And Optic Atrophy Art

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15893	XPO7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21460	Xpo7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27978	Xpo7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	XPO7	VGNC	VGNC:48464
Mus musculus	XPO7	MGD	MGI:1929705
Bos taurus	XPO7	VGNC	VGNC:37001
Felis catus	XPO7	VGNC	VGNC:67115
Rattus norvegicus	XPO7	RGD	RGD:1310928
Macaca mulatta	XPO7	VGNC	VGNC:78946
Others	XPO7	NCBI