FGD5 - FYVE, RhoGEF and PH domain containing 5 Gene

Homo sapiens

Also known as ZFYVE23

Gene ID: 152273 | Gene type: protein coding

About FGD5

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:14,810,688-14,934,571 (from NCBI)

This gene has 7 transcripts (splice variants), 270 orthologues and 10 paralogues. Broad expression in spleen (RPKM 15.9), lung (RPKM 13.8) and 22 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

FGD5 Products(2)

mRNA	Protein	Name
NM_001320276.2	NP_001307205.1	FYVE, RhoGEF and PH domain-containing protein 5 isoform 2
NM_152536.4	NP_689749.3	FYVE, RhoGEF and PH domain-containing protein 5 isoform 1

FGD5 Protein Structure

RhoGEF

FYVE

0
300
600
900
1200
1462 a.a.

Protein Preferred Names

Protein Names

FYVE, RhoGEF and PH domain-containing protein 5

zinc finger FYVE domain-containing protein 23

Related Diseases

Diseases

Alias

Aarskog-Scott Syndrome

Aarskog Syndrome	Faciogenital Dysplasia
Faciodigitogenital Syndrome	AAS
Fgdy	X-Linked Aarskog Syndrome
Intellectual Developmental Disorder, X-Linked, Syndromic 16	Aarskog Syndrome, X-Linked
Intellectual Developmental Disorder, X-Linked Syndromic 16	Greig'S Syndrome
Aarskog Scott Syndrome	Aarskog Disease
Scott Aarskog Syndrome	Facio-Digito-Genital Dysplasia
Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder	Aarskog-Scott Syndrome ) Syndrome

Gastroduodenitis

Breast Abscess

Abscess Of Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04884	FGD5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FGD5	MGD	MGI:2443369
Canis familiaris	FGD5	VGNC	VGNC:40837
Rattus norvegicus	FGD5	RGD	RGD:1305589
Macaca mulatta	FGD5	VGNC	VGNC:72533
Bos taurus	FGD5	VGNC	VGNC:28968
Felis catus	FGD5	VGNC	VGNC:62243