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54851

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4

Inhibitors & Agonists

1

Inhibitory Antibodies

1

Recombinant Proteins

7

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13649
    Indibulin
    1 Publications Verification

    ZIO 301; D 24851

    		 Apoptosis Microtubule/Tubulin Checkpoint Kinase (Chk) Neurological Disease Cancer
    Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis .
    Indibulin
  • HY-U00239
    SC58451

    		COX Inflammation/Immunology
    SC58451 is a potent and selective Cox-2 inhibitor.
    SC58451
  • HY-13649R
    Indibulin (Standard)

    ZIO 301 (Standard); D 24851 (Standard)

    		 Microtubule/Tubulin Apoptosis Reference Standards Neurological Disease Cancer
    Indibulin (Standard) is the analytical standard of Indibulin. This product is intended for research and analytical applications. Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis .
    Indibulin (Standard)
  • HY-P991555
    XmAb5485

    		TNF Receptor Apoptosis Cancer
    XmAb5485 is an Fc-engineered humanized anti-CD40 monoclonal antibody with high affinity to Fc-γ receptors. XmAb5485 induces potent antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) against tumor cells. XmAb5485 inhibits proliferation and induces apoptosis of tumor cells. XmAb5485 shows highly cytotoxic against lymphoma, leukemia and multiple myeloma cell lines as well as primary cancer cells .
    XmAb5485

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