TCAP - titin-cap Gene

Also Known as TELE; CMD1N; CMH25; T-cap; LGMD2G; LGMDR7; telethonin

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8557

About TCAP

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,665,349-39,666,554 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and is associated with 5 phenotypes. Restricted expression toward heart (RPKM 1072.6).

Summary

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and Other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]

TCAP Products (1)

mRNA	Protein	Name
NM_003673.4	NP_003664.1	telethonin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables BMP binding	IPI IPI: Inferred from physical interaction	17921333	GOA
enables FATZ binding	IPI IPI: Inferred from physical interaction	15582318	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	16713295	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10984498	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	15582318	GOA
enables structural constituent of muscle	IMP IMP: Inferred from mutant phenotype	9817758	GOA
enables titin Z domain binding	IPI IPI: Inferred from physical interaction	11846417	GOA
enables titin binding	IPI IPI: Inferred from physical interaction	9817758	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	11697903	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adult heart development	IMP IMP: Inferred from mutant phenotype	9817758	GOA
involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	9817758	GOA
involved in cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	12507422	GOA
involved in cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	15582318	GOA
involved in cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	12507422	GOA
involved in cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	9817758	GOA
involved in cardiac myofibril assembly	IMP IMP: Inferred from mutant phenotype	9817758	GOA
involved in detection of muscle stretch	IMP IMP: Inferred from mutant phenotype	12507422	GOA
involved in sarcomere organization	IMP IMP: Inferred from mutant phenotype	9817758	GOA
involved in sarcomerogenesis	IMP IMP: Inferred from mutant phenotype	9817758	GOA
involved in skeletal muscle contraction	IEP IEP: Inferred from expression pattern	9817758	GOA
involved in skeletal muscle myosin thick filament assembly	IMP IMP: Inferred from mutant phenotype	9817758	GOA
involved in skeletal muscle thin filament assembly	IMP IMP: Inferred from mutant phenotype	9817758	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Z disc	IDA IDA: Inferred from direct assay	9817758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCAP Protein Structure

Telethonin

0
100
167 a.a.

Protein Preferred Names	Protein Names
telethonin	19 kDa sarcomeric protein

TCAP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TCAP	O15273	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	TCAP	O15273	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	TCAP	O15273	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	TCAP	O15273	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	TCAP	O15273	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	TCAP	O15273	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	TCAP	O15273	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	TCAP	O15273	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	TCAP	O15273	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	ACTMAP	Homo sapiens	Q5BKX5-3	Validated Y2H	32296183
Intra	TCAP	O15273	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	TCAP	O15273	FAM153B	Homo sapiens	P0C7A2-2	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	FAM153B	Homo sapiens	P0C7A2-2	Validated Y2H	32296183
Intra	TCAP	O15273	FAM153B	Homo sapiens	P0C7A2-2	Y2H Array	32296183
Intra	TCAP	O15273	SAPCD1	Homo sapiens	Q5SSQ6-2	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	SAPCD1	Homo sapiens	Q5SSQ6-2	Validated Y2H	32296183
Intra	TCAP	O15273	SAPCD1	Homo sapiens	Q5SSQ6-2	Y2H Array	32296183
Intra	TCAP	O15273	CDCA4	Homo sapiens	Q9BXL8	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	CDCA4	Homo sapiens	Q9BXL8	Validated Y2H	32296183
Intra	TCAP	O15273	CDCA4	Homo sapiens	Q9BXL8	Y2H Array	32296183
Intra	TCAP	O15273	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	TCAP	O15273	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	TCAP	O15273	F13A1	Homo sapiens	P00488	Y2H Pooling	32814053
Intra	TCAP	O15273	F13A1	Homo sapiens	P00488	Validated Y2H	32814053
Intra	TCAP	O15273	F13A1	Homo sapiens	P00488	Y2H Array	32814053
Intra	TCAP	O15273	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	TCAP	O15273	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	TCAP	O15273	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	TCAP	O15273	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
Intra	TCAP	O15273	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
Intra	TCAP	O15273	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
Intra	TCAP	O15273	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	TCAP	O15273	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	TCAP	O15273	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	TCAP	O15273	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	TCAP	O15273	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	TCAP	O15273	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	TCAP	O15273	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	28514442
Intra	TCAP	O15273	HSPA8	Homo sapiens	P11142	Y2H Fragment Pooling	23414517
Intra	TCAP	O15273	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	33961781
Intra	TCAP	O15273	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	TCAP	O15273	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	TCAP	O15273	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	TCAP	O15273	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	TCAP	O15273	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	TCAP	O15273	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	ASB6	Homo sapiens	Q9NWX5	Validated Y2H	32296183
Intra	TCAP	O15273	ASB6	Homo sapiens	Q9NWX5	Y2H Array	32296183
Intra	TCAP	O15273	ASB6	Homo sapiens	Q9NWX5	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	TTN	Homo sapiens	Q8WZ42	Y2H	11846417
Intra	TCAP	O15273	TTN	Homo sapiens	Q8WZ42	Y2H Fragment Pooling	23414517
Intra	TCAP	O15273	TTN	Homo sapiens	Q8WZ42	Y2H	15582318
Intra	TCAP	O15273	LAMTOR5	Homo sapiens	O43504	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	LAMTOR5	Homo sapiens	O43504	Y2H Fragment Pooling	23414517
Intra	TCAP	O15273	LAMTOR5	Homo sapiens	O43504	Y2H Array	32296183
Intra	TCAP	O15273	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	TCAP	O15273	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	TCAP	O15273	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	TCAP	O15273	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	TCAP	O15273	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	TCAP	O15273	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	TCAP	O15273	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	TCAP	O15273	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	TCAP	O15273	MYOZ2	Homo sapiens	Q9NPC6	Pull Down	15582318
Intra	TCAP	O15273	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	TCAP	O15273	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	TCAP	O15273	CBX5	Homo sapiens	P45973	Y2H Prey Pooling	32296183
Intra	TCAP	O15273	CBX5	Homo sapiens	P45973	Validated Y2H	32296183
Intra	TCAP	O15273	CBX5	Homo sapiens	P45973	Anti Tag CoIP	33961781
Intra	TCAP	O15273	CBX5	Homo sapiens	P45973	Y2H Array	32296183
Intra	TCAP	O15273	CBX5	Homo sapiens	P45973	Anti Tag CoIP	28514442
Intra	TCAP	O15273	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	TCAP	O15273	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	TCAP	O15273	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	TCAP	O15273	ATXN1	Homo sapiens	P54253	Y2H Fragment Pooling	23414517
Intra	TCAP	O15273	ATXN1	Homo sapiens	P54253	Y2H Array	16713569
Intra	TCAP	O15273	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cardiomyopathy, Familial Hypertrophic, 25	Hypertrophic Cardiomyopathy 25 CMH25 Cardiomyopathy, Hypertrophic, 25 Cardiomyopathy Familial Hypertrophic 25 Cardiomyopathy, Familial Hypertrophic 25 Cardiomyopathy, Hypertrophic, Type 25
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 7	Muscular Dystrophy, Limb-Girdle, Type 2g Lgmd2g LGMDR7 Limb-Girdle Muscular Dystrophy, Type 2g Telethonin-Related Limb-Girdle Muscular Dystrophy R7 Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2g Lgmd Due To Telethonin Deficiency Lgmd Type 2g Limb-Girdle Muscular Dystrophy Due To Telethonin Deficiency Limb-Girdle Muscular Dystrophy Type 2g Telethonin-Related Lgmd R7 Limb-Girdle Muscular Dystrophy 2g Dystrophy, Muscular, Limb-Girdle, Type 2g
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2g	Lgmd2g Limb-Girdle Muscular Dystrophy Due To Telethonin Deficiency Muscular Dystrophy, Limb-Girdle, Type 2g
Creatine Phosphokinase, Elevated Serum	Hyperckemia, Idiopathic Cpk, Elevated Serum Hyperckmia HYPCK
Isolated Elevated Serum Creatine Phosphokinase Levels	Elevated Serum Cpk Idiopathic Hyperckemia Isolated Hyperckemia Elevated Serum Creatine Phosphokinase H-Ck Idiopathic Persistent Elevation Of Serum Creatine Kinase
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1
Familial Isolated Dilated Cardiomyopathy	Familial Or Idiopathic Dilated Cardiomyopathy
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Limb-Girdle Muscular Dystrophy	Lgmd Limb Girdle Muscular Dystrophy Muscular Dystrophies, Limb-Girdle Erb'S Muscular Dystrophy Leyden-Mbius Muscular Dystrophy Limb-Girdle Syndrome Myopathic Limb-Girdle Syndrome Limb Girdle Muscular Dystrophy Limb-Girdle Dystrophy, Muscular, Limb-Girdle Lgmd - [Limb-Girdle Muscular Dystrophy] Limb Girdle Muscle Dystrophy Limb-Girdle Myopathy
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 2	Lgmd2b Muscular Dystrophy, Limb-Girdle, Type 2b Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2e Beta-Sarcoglycanopathy Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2y Muscular Dystrophy, Limb-Girdle, Type 3 Lgmd3 Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2s LGMDR2 Muscular Dystrophy, Limb-Girdle, Type 2s Limb-Girdle Muscular Dystrophy Type 2b Lgmd2e Limb-Girdle Muscular Dystrophy Due To Beta-Sarcoglycan Deficiency Muscular Dystrophy, Limb-Girdle, Type 2e Lgmd2s Autosomal Recessive Muscular Dystrophy Due To Lap1b Deficiency Autosomal Recessive Muscular Dystrophy Due To Torsin-1a-Interacting Protein 1 Deficiency Lgmd2y Muscular Dystrophy With Progressive Weakness, Distal Contractures And Rigid Spine Muscular Dystrophy, Limb-Girdle, Type 2y Dysferlin-Related Limb-Girdle Muscular Dystrophy R2 Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b Dysferlin-Related Lgmd R2 Lgmd Due To Dysferlin Deficiency Lgmd Type 2b Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency Limb-Girdle Muscular Dystrophy 2b Limb-Girdle Muscular Dystrophy, Type 2b Dystrophy, Muscular, Limb-Girdle, Autosomal Recessive, Type 2 Dystrophy, Muscular, Limb-Girdle, Type 2b Limb-Girdle Muscular Dystrophy, Type 2e
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Muscular Dystrophy-Dystroglycanopathy , Type C, 5	Lgmd2i Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2i MDDGC5 Limb-Girdle Muscular Dystrophy Due To Fkrp Deficiency Limb-Girdle Muscular Dystrophy Type 2i Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 9 Lgmdr9 Muscular Dystrophy, Limb-Girdle, Type 2i Muscular Dystrophy-Dystroglycanopathy Limb-Girdle Frkp-Related Fkrp-Related Limb-Girdle Muscular Dystrophy R9 Fkrp-Related Lgmd R9 Lgmd Due To Fkrp Deficiency Lgmd Type 2i Muscular Dystrophy-Dystroglycanopathy, Limb-Girdle, Frkp-Related Muscular Dystrophy Limb-Girdle Type 2i Muscular Dystrophy-Dystroglycanopathy Type C 5 Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C5 Dystrophy, Muscular, Limb-Girdle, Type 2i
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 8	Sarcotubular Myopathy Lgmd2h Muscular Dystrophy, Limb-Girdle, Type 2h Limb-Girdle Muscular Dystrophy Type 2h LGMDR8 Muscular Dystrophy Hutterite Type Muscular Dystrophy, Hutterite Type Muscular Dystrophy Limb-Girdle Type 2h Trim32-Related Limb-Girdle Muscular Dystrophy R8 Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h Lgmd Due To Trim32 Deficiency Lgmd Type 2h Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency Trim32-Related Lgmd R8 Limb-Girdle Muscular Dystrophy 2h Dystrophy, Muscular, Limb-Girdle, Type 2h
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 6	Lgmd2f Muscular Dystrophy, Limb-Girdle, Type 2f Limb-Girdle Muscular Dystrophy Type 2f LGMDR6 Muscular Dystrophy Limb-Girdle With Delta-Sarcoglyan Deficiency Delta-Sarcoglycan-Related Limb-Girdle Muscular Dystrophy R6 Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2f Delta-Sarcoglycan-Related Lgmd R6 Delta-Sarcoglycanopathy Lgmd Due To Delta-Sarcoglycan Deficiency Lgmd Type 2f Limb-Girdle Muscular Dystrophy Due To Delta-Sarcoglycan Deficiency Limb-Girdle Muscular Dystrophy 2f Limb-Girdle Muscular Dystrophy, Type 2f Dystrophy, Muscular, Limb-Girdle, Type 2f
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 4	Lgmd2e Muscular Dystrophy, Limb-Girdle, Type 2e LGMDR4 Beta-Sarcoglycan-Related Limb-Girdle Muscular Dystrophy R4 Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2e Beta-Sarcoglycan-Related Lgmd R4 Beta-Sarcoglycanopathy Lgmd Due To Beta-Sarcoglycan Deficiency Lgmd Type 2e Limb-Girdle Muscular Dystrophy Due To Beta-Sarcoglycan Deficiency Limb-Girdle Muscular Dystrophy Type 2e Limb-Girdle Muscular Dystrophy 2e
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Limb-Girdle Muscular Dystrophy Type 1a	Lgmd1a Lgmd1 Muscular Dystrophy, Proximal, Type 1a Limb-Girdle Muscular Dystrophy, Type 1a Dystrophy, Muscular, Limb-Girdle, Type 1a
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2j	Lgmd2j Muscular Dystrophy, Limb-Girdle, Type 2j
Myopathy	Muscular Diseases Myopathies
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2q	Autosomal Recessive Limb-Girdle Muscular Dystrophy Due To Plectin Deficiency Lgmd2q Muscular Dystrophy, Limb-Girdle, Type 2q
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2a	Leyden-Moebius Muscular Dystrophy Lgmd2a Limb-Girdle Muscular Dystrophy Due To Calpain Deficiency Muscular Dystrophy, Limb-Girdle, Type 2a Pelvofemoral Muscular Dystrophy Primary Calpainopathy
Myasthenic Syndrome, Congenital, 20, Presynaptic	Congenital Myasthenic Syndrome 20 CMS20 Congenital Myasthenic Syndrome 20 Presynaptic Myasthenic Syndrome, Congenital, Type 20, Presynaptic
Tibial Muscular Dystrophy	Tmd Udd Myopathy Distal Titinopathy Finnish Tibial Muscular Dystrophy Tardive Tibial Muscular Dystrophy Udd Type Distal Myopathy Udd Distal Myopathy Udd-Markesbery Muscular Dystrophy Distal Myopathy, Udd Type Distal Myopathies Tibial Muscular Dystrophy, Tardive
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b	Lgmd2b Lgmd3 Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency Limb-Girdle Muscular Dystrophy Type 3 Muscular Dystrophy, Limb-Girdle, Type 2b
Miyoshi Muscular Dystrophy	Distal Myopathy Distal Muscular Dystrophy Miyoshi Myopathy Distal Myopathies Dystrophy, Muscular, Miyoshi Myopathy, Distal Distal Muscular Dystrophies
Myopathy, Myofibrillar, 9, With Early Respiratory Failure	Hereditary Myopathy With Early Respiratory Failure Hmerf Myopathy, Proximal, With Early Respiratory Muscle Involvement Edstrom Myopathy Mfm-Titinopathy MFM9 Mprm Hereditary Inclusion Body Myopathy With Early Respiratory Failure Hibm-Erf Myofibrillar Myopathy-Titinopathy Myofibrillar Myopathy With Early Respiratory Failure Myopathy, Distal, With Early Respiratory Failure, Autosomal Dominant Myofibrillar Myopathy 9 Myofibrillar Myopathy 9 With Early Respiratory Failure Autosomal Dominant Distal Myopathy With Early Respiratory Failure Proximal Myopathy With Early Respiratory Muscle Involvement Hereditary Proximal Myopathy With Early Respiratory Failure Admerf Edström Myopathy Hmerf-Erf
Myopathy, Myofibrillar, 3	Myotilinopathy Myofibrillar Myopathy 3 MFM3 Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1a Lgmd1a Muscular Dystrophy, Limb-Girdle, Type 1a Myopathy, Myofibrillar, Myotilin-Related Muscular Dystrophy, Limb-Girdle, Type 1, Formerly Lgmd1, Formerly Muscular Dystrophy, Limb-Girdle, Type 1a, Formerly Lgmd1a, Formerly Qualitative Or Quantitative Defects Of Myotilin Limb-Girdle Muscular Dystrophy Due To Myotilin Deficiency Distal Myotilinopathy Lgmd1 Limb-Girdle Muscular Dystrophy 1a Mfm Myotilin-Related Muscular Dystrophy, Limb-Girdle, Type 1 Myopathy Myofibrillar Myotylin-Related Myopathy, Myofibrillar, Type 3
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Cylindrical Spirals Myopathy	Myotonic Myopathy With Cylindrical Spirals
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2c	Autosomal Recessive Duchenne-Like Muscular Dystrophy Type 1 Deficiency Of Sarcoglycan Gamma Dmda1 Gamma-Sarcoglycanopathy Lgmd2c Limb-Girdle Muscular Dystrophy Due To Gamma-Sarcoglycan Deficiency Maghrebian Myopathy Muscular Dystrophy, Limb-Girdle, Type 2c Scarmd Severe Childhood Autosomal Recessive Muscular Dystrophy North African Type
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Myopathy, Spheroid Body	Spheroid Body Myopathy Autosomal Dominant Spheroid Body Myopathy SBM
Myopathy, Myofibrillar, 4	Myofibrillar Myopathy 4 MFM4 Zaspopathy Myopathy, Myofibrillar, Zasp-Related
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2f	Delta-Sarcoglycanopathy Lgmd2f Limb-Girdle Muscular Dystrophy Due To Delta-Sarcoglycan Deficiency Limb-Girdle Muscular Dystrophy Type 2f
Cardiomyopathy, Dilated, 1m	Dilated Cardiomyopathy 1m CMD1M Cardiomyopathy, Dilated 1m Cardiomyopathy, Dilated, Type 1m
Autosomal Dominant Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Dominant
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2d	Alpha-Sarcoglycanopathy Dmda2 Duchenne-Like Autosomal Recessive Muscular Dystrophy Type 2 Lgmd2d Muscular Dystrophy, Limb-Girdle, Type 2d Primary Adhalinopathy
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h	Lgmd2h Limb-Girdle Muscular Dystrophy Due To Trim32 Deficiency Muscular Dystrophy Hutterite Type Sarcotubular Myopathy Limb-Girdle Muscular Dystrophy Type 2h
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 2	Muscular Dystrophy, Limb-Girdle, Type 1f Lgmd1f Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1f LGMDD2 Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 2 Muscular Dystrophy Limb-Girdle Type 1f Tnp03-Related Limb-Girdle Muscular Dystrophy D2 Lgmd Type 1f Limb-Girdle Muscular Dystrophy Type 1f Limb-Girdle Muscular Dystrophy 1f Dystrophy, Muscular, Limb-Girdle, Type 1f
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 1	Muscular Dystrophy, Limb-Girdle, Type 1e Lgmd1d Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1d LGMDD1 Lgmd1e Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1 Limb-Girdle Muscular Dystrophy Type 1d Muscular Dystrophy, Limb-Girdle, Type 1d Muscular Dystrophy, Limb-Girdle, Type 1d, Formerly Lgmd1d, Formerly Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1e Muscular Dystrophy Limb-Girdle Type 1d Muscular Dystrophy Limb-Girdle Type 1e Dnajb6-Related Limb-Girdle Muscular Dystrophy D1 Dnajb6-Related Lgmd D1 Lgmd Type 1d Limb-Girdle Muscular Dystrophy 1e Limb-Girdle Muscular Dystrophy-1d, Autosomal Dominant Dystrophy, Muscular, Limb-Girdle, Autosomal Dominant, Type 1 Dystrophy, Muscular, Limb-Girdle, Type 1e
Myofibrillar Myopathy	Desmin Related Myopathy Myotilinopathy Myopathy, Myofibrillar Alpha Beta Crystallinopathy Desmin Storage Myopathy Desminopathy Filaminopathy Protein Surplus Myopathy Zaspopathy Myofibrillar Myopathies Myopathy, Myofibrillar, Desmin-Related Myopathy, Desmin Storage Mfm - [Myofibrillar Myopathy]
Muscular Dystrophy, Duchenne Type	Duchenne Muscular Dystrophy DMD Muscular Dystrophy, Duchenne Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type Severe Dystrophinopathy, Duchenne Type Muscular Dystrophy Duchenne Dystrophy, Muscular, Duchenne Type Benign Duchenne Muscular Dystrophy Duchenne Motor Neuron Disease Duchenne Type Dystrophy Duchenne-Griesinger Disease
Facioscapulohumeral Muscular Dystrophy 1	Facioscapulohumeral Muscular Dystrophy Fshd Landouzy-Dejerine Muscular Dystrophy Muscular Dystrophy, Facioscapulohumeral FSHD1 Fshd1a Muscular Dystrophy, Facioscapulohumeral, Type 1a Facioscapulohumeral Muscular Dystrophy Type 1a Fsh Muscular Dystrophy Facioscapulohumeral Muscular Dystrophy 1a Facioscapulohumeral Atrophy Facioscapulohumeral Myopathy Muscular Dystrophy, Facioscapulohumeral, Type 1 Facioscapulohumeral Muscular Dystrophy Type 1 Landouzy Dejerine Muscular Dystrophy Muscular Dystrophy, Landouzy-Dejerine Fshmd1a Facio-Scapulo-Humeral Dystrophy Facioscapulohumeral Type Progressive Muscular Dystrophy Facioscapuloperoneal Muscular Dystrophy Facioscapulohumeral Dystrophy Fsh Dystrophy Landouzy-Dejerine Dystrophy Landouzy-Dejerine Myopathy Fmd Facioscapulohumeral Muscular Dystrophy-1a Muscular Dystrophy Facioscapulohumeral Dystrophy, Muscular, Facioscapulohumeral Dystrophy, Muscular, Facioscapulohumeral, Type 1 Landouzy-Dejerine Disease Landouzy-Déjerine Atrophy Facioscapulohumeral Muscle Dystrophy Fmd - [Facioscapulohumeral Muscular Dystrophy] Fsh - [Facioscapulohumeral Muscular Dystrophy] Fshd - [Facioscapulohumeral Muscular Dystrophy] Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy Landouzy-Déjérine Muscular Dystrophy
Intestinal Pseudo-Obstruction	Chronic Intestinal Pseudoobstruction Chronic Intestinal Pseudo-Obstruction Cipo Neuronal Intestinal Dysplasia Hollow Visceral Myopathy Familial Visceral Neuropathy Paralytic Ileus Intestinal Pseudoobstruction Chronic Idiopathic Intestinal Pseudo-Obstruction Ciip Congenital Short Bowel Syndrome Enteric Neuropathy Familial Visceral Myopathy Ipo Pseudo-Obstruction Of Intestine Pseudointestinal Obstruction Syndrome Pseudoobstructive Syndrome Congenital Idiopathic Intestinal Pseudoobstruction Visceral Myopathy, Familial
Left Ventricular Noncompaction	Noncompaction Cardiomyopathy Left Ventricular Hypertrabeculation Lvnc Spongy Myocardium Isolated Noncompaction Of The Ventricular Myocardium Left Ventricular Myocardial Noncompaction Cardiomyopathy Fetal Myocardium Honeycomb Myocardium Hypertrabeculation Syndrome Left Ventricular Non-Compaction Lvht Non-Compaction Of The Left Ventricular Myocardium Ventricular Noncompaction, Left Non-Compaction Cardiomyopathy
Intrinsic Cardiomyopathy
Restrictive Cardiomyopathy	Familial Restrictive Cardiomyopathy Cardiomyopathy, Restrictive Cardiomyopathy, Constrictive Primary Restrictive Cardiomyopathy Rcm Cardiomyopathy Restrictive
Distal Arthrogryposis	Arthrogryposis Multiplex Congenita Arthrogryposis Congenital Multiple Arthrogryposis Congenital Arthromyodysplasia Fibrous Ankylosis Of Multiple Joints Guerin-Stern Syndrome Guérin-Stern Syndrome Myodystrophia Fetalis Deformans Otto Syndrome Rocher-Sheldon Syndrome Rossi Syndrome Amc Multiple Congenital Arthrogryposis Arthrogryposis Syndrome Arthrogryposis, Distal Distal Arthrogryposis Syndrome Freeman-Sheldon Syndrome Arthrogryposis, Distal, Type 2b Congenital Multiplex Arthrogryposis Amyoplasia Congenita Congenital Amyoplasia Amc - [Arthrogryposis Multiplex Congenita]
Familial Atrial Fibrillation	Atrial Fibrillation, Familial Atfb Atrial Fibrillation Autosomal Dominant Autosomal Dominant Atrial Fibrillation Auricular Fibrillation Atrial Fibrillation Atrial Fibrillation, Familial, 1
Walker-Warburg Syndrome	Hard Syndrome Walker-Warburg Congenital Muscular Dystrophy Cerebroocular Dysplasia-Muscular Dystrophy Syndrome Cod-Md Syndrome Chemke Syndrome Hydrocephalus, Agyria And Retinal Dysplasia Cerebroocular Dysgenesis Cerebroocular Dysplasia Muscular Dystrophy Syndrome Hard +/- E Syndrome Pagon Syndrome Warburg Syndrome Hydrocephalus, Agyria, And Retinal Dysplasia Mddga Muscular Dystrophy-Dystroglycanopathy , Type A Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A Hydrocephalus-Agyria-Retinal Dysplasia Syndrome Wws Dystrophy, Muscular, Dystroglycanopathy, Type A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14291	TCAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22341	Tcap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28863	Tcap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TCAP	RGD	RGD:1592387
Mus musculus	TCAP	MGD	MGI:1330233
Canis familiaris	TCAP	VGNC	VGNC:47181
Bos taurus	TCAP	VGNC	VGNC:35678
Felis catus	TCAP	VGNC	VGNC:66014
Others	TCAP	NCBI