LAMTOR5 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Gene

Also Known as XIP; HBXIP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10542

About LAMTOR5

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,401,253-110,407,924 (from NCBI)

This gene has 7 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in kidney (RPKM 162.7), bone marrow (RPKM 53.1) and 24 other tissues.

Summary

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

LAMTOR5 Products (2)

mRNA Protein Name
NM_001382293.1 NP_001369222.1 ragulator complex protein LAMTOR5 isoform 2
NM_006402.3 NP_006393.2 ragulator complex protein LAMTOR5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
22980980 GOA
contributes to molecular adaptor activity IDA
IDA: Inferred from direct assay
22980980 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12773388 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
22980980 GOA
involved in cellular response to amino acid stimulus IMP
IMP: Inferred from mutant phenotype
22980980 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
12773388 GOA
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IGI
IGI: Inferred from genetic interaction
21343296 GOA
acts upstream of positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21343296 GOA
involved in positive regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
22980980 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
28935770 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
21343296 GOA
acts upstream of positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
21343296 GOA
involved in positive regulation of interleukin-8 production IGI
IGI: Inferred from genetic interaction
21343296 GOA
involved in positive regulation of protein localization to nucleus IDA
IDA: Inferred from direct assay
21343296 GOA
involved in protein localization to lysosome IMP
IMP: Inferred from mutant phenotype
22980980 GOA
involved in regulation of cell size IMP
IMP: Inferred from mutant phenotype
22980980 GOA
Cellular Component GO Annotation Evidence References Source
part of FNIP-folliculin RagC/D GAP IDA
IDA: Inferred from direct assay
36103527 GOA
part of Ragulator complex IDA
IDA: Inferred from direct assay
22980980 GOA
part of Ragulator complex IPI
IPI: Inferred from physical interaction
28935770 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12773388 GOA
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
29158492 GOA
located in lysosome IDA
IDA: Inferred from direct assay
22980980 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
12773388 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ragulator complex protein LAMTOR5

  • HBV X-interacting protein

LAMTOR5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LAMTOR5 O43504 FKBP1A Homo sapiens Q0VDC6
Validated Y2H
32814053
Intra
LAMTOR5 O43504 FKBP1A Homo sapiens Q0VDC6
Y2H Array
32814053
Intra
LAMTOR5 O43504 FKBP1A Homo sapiens Q0VDC6
Y2H Pooling
32814053
Intra
LAMTOR5 O43504 SARS1 Homo sapiens P49591
Validated Y2H
32814053
Intra
LAMTOR5 O43504 SARS1 Homo sapiens P49591
Y2H Pooling
32814053
Intra
LAMTOR5 O43504 SARS1 Homo sapiens P49591
Y2H Array
32814053
Intra
LAMTOR5 O43504 AK6 Homo sapiens Q9Y3D8
Y2H Array
25416956
Intra
LAMTOR5 O43504 AK6 Homo sapiens Q9Y3D8
Y2H Prey Pooling
25416956
Intra
LAMTOR5 O43504 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
LAMTOR5 O43504 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
LAMTOR5 O43504 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
LAMTOR5 O43504 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
LAMTOR5 O43504 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
LAMTOR5 O43504 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
LAMTOR5 O43504 HSPA2 Homo sapiens P54652
Validated Y2H
32814053
Intra
LAMTOR5 O43504 HSPA2 Homo sapiens P54652
Y2H Array
32814053
Intra
LAMTOR5 O43504 HSPA2 Homo sapiens P54652
Y2H Pooling
32814053
Intra
LAMTOR5 O43504 BIRC5 Homo sapiens O15392
Validated Y2H
32296183
Intra
LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Y2H Prey Pooling
32296183
Intra
LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
33961781
Intra
LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
MAPPIT
32296183
Intra
LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Validated Y2H
32296183
Intra
LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Affinity Chrom
22980980
Intra
LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Y2H Array
32296183
Intra
LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
25561175
Intra
LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Y2H Prey Pooling
32296183
Intra
LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Validated Y2H
32296183
Intra
LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Y2H Array
25416956
Intra
LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Y2H Pooling
16169070
Intra
LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Y2H Array
32296183
Intra
LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Y2H Fragment Pooling
23414517
Intra
LAMTOR5 O43504 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra
LAMTOR5 O43504 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
LAMTOR5 O43504 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
LAMTOR5 O43504 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
LAMTOR5 O43504 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
32814053
Intra
LAMTOR5 O43504 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32814053
Intra
LAMTOR5 O43504 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32814053
Intra
LAMTOR5 O43504 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
LAMTOR5 O43504 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra
LAMTOR5 O43504 TCAP Homo sapiens O15273
Y2H Fragment Pooling
23414517
Intra
LAMTOR5 O43504 TCAP Homo sapiens O15273
Validated Y2H
32296183
Intra
LAMTOR5 O43504 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
33961781
Intra
LAMTOR5 O43504 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
25561175
Cross
LAMTOR5 O43504 Q9WMX2-PRO_0000037547 Hepatitis C virus Q9WMX2-PRO_0000037547
Pull Down
24169621
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatitis B

  • Chronic Hepatitis B

  • Hepatitis B Infection

  • Serum Hepatitis

  • HBV

  • Hepatitis B Chronic

  • Hbv, Susceptibility To

  • Hepatitis B, Chronic

  • Chronic Hepatitis B Without Delta Agent

  • Chronic Hbv - [Hepatitis B Virus] Infection

  • Hepatitis B Nos

  • Chronic Type B Viral Hepatitis

  • Hep B Nos
Hepatitis

  • Chronic Hepatitis

  • Chronic Persistent Hepatitis

  • Acute Hepatitis

  • Hepatitis, Chronic

  • Acute And Subacute Liver Necrosis

  • Acute/Subac. Necrosis Of Liver

  • Animal Hepatitis

  • Hepatitis Chronic

  • Hepatitis A

  • Hepatitis, Animal

  • Hepatitis Due To Toxoplasmosis

  • Hepatitis In Toxoplasmosis

  • Toxoplasmal Hepatitis

  • Chronic Hepatitis, Unspecified

  • Chronic Active Hepatitis Nec

  • Other Specified Chronic Hepatitis

  • Chronic Persistent Hepatitis Nec

  • Chronic Lobular Hepatitis Nec
Lobomycosis

  • Cutaneous Blastomycosis

  • Cutaneous Lobomycosis

  • Infection By Loboa Loboi

  • Lobo Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07517 LAMTOR5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LAMTOR5 RGD RGD:1305005
Felis catus LAMTOR5 VGNC VGNC:82532
Bos taurus LAMTOR5 VGNC VGNC:55244
Mus musculus LAMTOR5 MGD MGI:1915826
Others LAMTOR5 NCBI