HSPA2 - heat shock protein family A (Hsp70) member 2 Gene

Homo sapiens

Also known as HSP70-2; HSP70-3

Gene ID: 3306 | Gene type: protein coding

About HSPA2

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,535,905-64,543,237 (from NCBI)

This gene has 3 transcripts (splice variants), 334 orthologues and 13 paralogues.

Summary

Enables disordered domain specific binding activity; Enzyme binding activity; and unfolded protein binding activity. Involved in negative regulation of inclusion body assembly and protein refolding. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

HSPA2 Products(2)

mRNA	Protein	Name
NM_001387931.1	NP_001374860.1	heat shock-related 70 kDa protein 2
NM_021979.4	NP_068814.2	heat shock-related 70 kDa protein 2

HSPA2 Protein Structure

HSP70

0
100
200
300
400
500
600
639 a.a.

Protein Preferred Names

Protein Names

heat shock-related 70 kDa protein 2

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Varicocele

Scrotal Varices	Varicoceles
Varicocele Of Scrotum	Scrotal Varicocele

Visceral Leishmaniasis

Kala-Azar	Leishmaniasis, Visceral
Infection By Visceral Leishmaniasis	Leishmaniasis Visceral
Sahib Disease	Ponos
Burdwan Fever	Mard El Bicha
Sirkari Disease	Indian Visceral Leishmaniasis
Dumdum Fever	Visceral Leishmaniasis Due To Leishmania Donovani

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152153	GRP78-IN-3	Inhibitor	99.98%	Unkown
HY-RS06427	HSPA2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HSPA2	VGNC	VGNC:50533
Rattus norvegicus	HSPA2	RGD	RGD:620664
Mus musculus	HSPA2	MGD	MGI:96243
Felis catus	HSPA2	VGNC	VGNC:80953

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