HSPA2 - heat shock protein family A (Hsp70) member 2 Gene

Also Known as HSP70-2; HSP70-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3306

About HSPA2

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,535,905-64,543,237 (from NCBI)

This gene has 3 transcripts (splice variants), 334 orthologues and 13 paralogues.

Summary

Enables disordered domain specific binding activity; enzyme binding activity; and unfolded protein binding activity. Involved in negative regulation of inclusion body assembly and protein refolding. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

HSPA2 Products (2)

mRNA Protein Name
NM_001387931.1 NP_001374860.1 heat shock-related 70 kDa protein 2
NM_021979.4 NP_068814.2 heat shock-related 70 kDa protein 2

HSPA2 Protein Structure

HSP70

HSP70: Hsp70 protein (7 - 615)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 639 a.a.
Protein Preferred Names Protein Names

heat shock-related 70 kDa protein 2

  • epididymis secretory sperm binding protein

HSPA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HSPA2 P54652 WBP1L Homo sapiens Q9NX94
Y2H Pooling
32814053
Intra
HSPA2 P54652 WBP1L Homo sapiens Q9NX94
Validated Y2H
32814053
Intra
HSPA2 P54652 WBP1L Homo sapiens Q9NX94
Y2H Array
32814053
Intra
HSPA2 P54652 LARP4B Homo sapiens Q92615
Y2H Pooling
32814053
Intra
HSPA2 P54652 LARP4B Homo sapiens Q92615
Validated Y2H
32814053
Intra
HSPA2 P54652 LARP4B Homo sapiens Q92615
Y2H Array
32814053
Intra
HSPA2 P54652 SPATA12 Homo sapiens Q7Z6I5
Validated Y2H
32814053
Intra
HSPA2 P54652 SPATA12 Homo sapiens Q7Z6I5
Y2H Array
32814053
Intra
HSPA2 P54652 SPATA12 Homo sapiens Q7Z6I5
Y2H Pooling
32814053
Intra
HSPA2 P54652 DNAJA3 Homo sapiens Q96EY1-3
Y2H Pooling
32814053
Intra
HSPA2 P54652 DNAJA3 Homo sapiens Q96EY1-3
Validated Y2H
32814053
Intra
HSPA2 P54652 DNAJA3 Homo sapiens Q96EY1-3
Y2H Array
32814053
Intra
HSPA2 P54652 CD209 Homo sapiens Q9NNX6-10
Validated Y2H
32814053
Intra
HSPA2 P54652 CD209 Homo sapiens Q9NNX6-10
Y2H Array
32814053
Intra
HSPA2 P54652 CD209 Homo sapiens Q9NNX6-10
Y2H Pooling
32814053
Intra
HSPA2 P54652 ZNF341 Homo sapiens Q9BYN7-2
Validated Y2H
32814053
Intra
HSPA2 P54652 ZNF341 Homo sapiens Q9BYN7-2
Y2H Pooling
32814053
Intra
HSPA2 P54652 ZNF341 Homo sapiens Q9BYN7-2
Y2H Array
32814053
Intra
HSPA2 P54652 SERTAD4 Homo sapiens Q9NUC0
Validated Y2H
32814053
Intra
HSPA2 P54652 SERTAD4 Homo sapiens Q9NUC0
Y2H Array
32814053
Intra
HSPA2 P54652 SERTAD4 Homo sapiens Q9NUC0
Y2H Pooling
32814053
Intra
HSPA2 P54652 ZNF829 Homo sapiens Q3KNS6-3
Y2H Array
32814053
Intra
HSPA2 P54652 ZNF829 Homo sapiens Q3KNS6-3
Y2H Pooling
32814053
Intra
HSPA2 P54652 ZNF829 Homo sapiens Q3KNS6-3
Validated Y2H
32814053
Intra
HSPA2 P54652 ZKSCAN3 Homo sapiens Q9BRR0
Validated Y2H
32814053
Intra
HSPA2 P54652 ZKSCAN3 Homo sapiens Q9BRR0
Y2H Array
32814053
Intra
HSPA2 P54652 ZKSCAN3 Homo sapiens Q9BRR0
Y2H Pooling
32814053
Intra
HSPA2 P54652 TRIM38 Homo sapiens O00635
Y2H Array
25416956
Intra
HSPA2 P54652 PLEKHG4 Homo sapiens Q58EX7-2
Y2H Array
32814053
Intra
HSPA2 P54652 PLEKHG4 Homo sapiens Q58EX7-2
Validated Y2H
32814053
Intra
HSPA2 P54652 PLEKHG4 Homo sapiens Q58EX7-2
Y2H Pooling
32814053
Intra
HSPA2 P54652 UBE2A Homo sapiens P49459
Validated Y2H
32814053
Intra
HSPA2 P54652 UBE2A Homo sapiens P49459
Y2H Pooling
32814053
Intra
HSPA2 P54652 UBE2A Homo sapiens P49459
Y2H Array
32814053
Intra
HSPA2 P54652 DPF1 Homo sapiens Q92782-2
Validated Y2H
32814053
Intra
HSPA2 P54652 DPF1 Homo sapiens Q92782-2
Y2H Array
32814053
Intra
HSPA2 P54652 DPF1 Homo sapiens Q92782-2
Y2H Pooling
32814053
Intra
HSPA2 P54652 ZNF124 Homo sapiens Q15973
Y2H Pooling
32814053
Intra
HSPA2 P54652 ZNF124 Homo sapiens Q15973
Validated Y2H
32814053
Intra
HSPA2 P54652 ZNF124 Homo sapiens Q15973
Y2H Array
32814053
Intra
HSPA2 P54652 HSF2 Homo sapiens Q03933
Lumier
25036637
Intra
HSPA2 P54652 OTUD7B Homo sapiens Q6GQQ9-2
Validated Y2H
32814053
Intra
HSPA2 P54652 OTUD7B Homo sapiens Q6GQQ9-2
Y2H Array
32814053
Intra
HSPA2 P54652 OTUD7B Homo sapiens Q6GQQ9-2
Y2H Pooling
32814053
Intra
HSPA2 P54652 TMEM61 Homo sapiens Q8N0U2
Y2H Pooling
32814053
Intra
HSPA2 P54652 TMEM61 Homo sapiens Q8N0U2
Validated Y2H
32814053
Intra
HSPA2 P54652 TMEM61 Homo sapiens Q8N0U2
Y2H Array
32814053
Intra
HSPA2 P54652 PRR3 Homo sapiens P79522
Validated Y2H
32814053
Intra
HSPA2 P54652 PRR3 Homo sapiens P79522
Y2H Array
32814053
Intra
HSPA2 P54652 PRR3 Homo sapiens P79522
Y2H Pooling
32814053
Intra
HSPA2 P54652 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
HSPA2 P54652 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
HSPA2 P54652 HSPBP1 Homo sapiens Q9NZL4
Validated Y2H
25416956
Intra
HSPA2 P54652 HSPBP1 Homo sapiens Q9NZL4
Y2H Array
16713569
Intra
HSPA2 P54652 HSPBP1 Homo sapiens Q9NZL4
Y2H Pooling
16189514
Intra
HSPA2 P54652 SSB Homo sapiens P05455
Validated Y2H
32814053
Intra
HSPA2 P54652 SSB Homo sapiens P05455
Y2H Array
32814053
Intra
HSPA2 P54652 SSB Homo sapiens P05455
Y2H Pooling
32814053
Intra
HSPA2 P54652 NEUROD1 Homo sapiens Q13562
Validated Y2H
32814053
Intra
HSPA2 P54652 NEUROD1 Homo sapiens Q13562
Y2H Array
32814053
Intra
HSPA2 P54652 NEUROD1 Homo sapiens Q13562
Y2H Pooling
32814053
Intra
HSPA2 P54652 FGF21 Homo sapiens Q9NSA1
Validated Y2H
32814053
Intra
HSPA2 P54652 FGF21 Homo sapiens Q9NSA1
Y2H Array
32814053
Intra
HSPA2 P54652 FGF21 Homo sapiens Q9NSA1
Y2H Pooling
32814053
Intra
HSPA2 P54652 FGF21 Homo sapiens Q9NSA1
Lumier
32814053
Intra
HSPA2 P54652 TSPAN2 Homo sapiens O60636
Y2H Array
32814053
Intra
HSPA2 P54652 TSPAN2 Homo sapiens O60636
Y2H Pooling
32814053
Intra
HSPA2 P54652 TSPAN2 Homo sapiens O60636
Validated Y2H
32814053
Intra
HSPA2 P54652 SPATS1 Homo sapiens Q496A3
Y2H Pooling
32814053
Intra
HSPA2 P54652 SPATS1 Homo sapiens Q496A3
Validated Y2H
32814053
Intra
HSPA2 P54652 SPATS1 Homo sapiens Q496A3
Y2H Array
32814053
Intra
HSPA2 P54652 SOCS6 Homo sapiens O14544
Validated Y2H
32814053
Intra
HSPA2 P54652 SOCS6 Homo sapiens O14544
Y2H Pooling
32814053
Intra
HSPA2 P54652 SOCS6 Homo sapiens O14544
Y2H Array
32814053
Intra
HSPA2 P54652 MAP3K5 Homo sapiens Q99683
Y2H Array
32814053
Intra
HSPA2 P54652 MAP3K5 Homo sapiens Q99683
Y2H Pooling
32814053
Intra
HSPA2 P54652 MAP3K5 Homo sapiens Q99683
Validated Y2H
32814053
Intra
HSPA2 P54652 ARL6IP4 Homo sapiens Q66PJ3-4
Validated Y2H
32814053
Intra
HSPA2 P54652 ARL6IP4 Homo sapiens Q66PJ3-4
Y2H Array
32814053
Intra
HSPA2 P54652 ARL6IP4 Homo sapiens Q66PJ3-4
Y2H Pooling
32814053
Intra
HSPA2 P54652 ASH2L Homo sapiens Q9UBL3
Y2H Pooling
32814053
Intra
HSPA2 P54652 ASH2L Homo sapiens Q9UBL3
Validated Y2H
32814053
Intra
HSPA2 P54652 ASH2L Homo sapiens Q9UBL3
Y2H Array
32814053
Intra
HSPA2 P54652 INCA1 Homo sapiens Q0VD86
Y2H Pooling
32814053
Intra
HSPA2 P54652 INCA1 Homo sapiens Q0VD86
Validated Y2H
32814053
Intra
HSPA2 P54652 INCA1 Homo sapiens Q0VD86
Y2H Array
32814053
Intra
HSPA2 P54652 POLR3F Homo sapiens Q9H1D9
Y2H Array
32814053
Intra
HSPA2 P54652 POLR3F Homo sapiens Q9H1D9
Validated Y2H
32814053
Intra
HSPA2 P54652 POLR3F Homo sapiens Q9H1D9
Y2H Pooling
32814053
Intra
HSPA2 P54652 POLA2 Homo sapiens Q14181
Validated Y2H
32814053
Intra
HSPA2 P54652 POLA2 Homo sapiens Q14181
Y2H Array
32814053
Intra
HSPA2 P54652 POLA2 Homo sapiens Q14181
Y2H Pooling
32814053
Intra
HSPA2 P54652 BAHD1 Homo sapiens Q8TBE0
Y2H Pooling
32814053
Intra
HSPA2 P54652 BAHD1 Homo sapiens Q8TBE0
Validated Y2H
32814053
Intra
HSPA2 P54652 BAHD1 Homo sapiens Q8TBE0
Y2H Array
32814053
Intra
HSPA2 P54652 FOSL1 Homo sapiens P15407
Validated Y2H
32814053
Intra
HSPA2 P54652 FOSL1 Homo sapiens P15407
Y2H Array
32814053
Intra
HSPA2 P54652 FOSL1 Homo sapiens P15407
Y2H Pooling
32814053
Intra
HSPA2 P54652 ASB9 Homo sapiens Q96DX5
Validated Y2H
32814053
Intra
HSPA2 P54652 ASB9 Homo sapiens Q96DX5
Y2H Array
32814053
Intra
HSPA2 P54652 ASB9 Homo sapiens Q96DX5
Y2H Pooling
32814053
Intra
HSPA2 P54652 CHMP7 Homo sapiens Q8WUX9
Y2H Pooling
32814053
Intra
HSPA2 P54652 CHMP7 Homo sapiens Q8WUX9
Validated Y2H
32814053
Intra
HSPA2 P54652 CHMP7 Homo sapiens Q8WUX9
Y2H Array
32814053
Intra
HSPA2 P54652 MIP Homo sapiens P30301
Validated Y2H
32814053
Intra
HSPA2 P54652 MIP Homo sapiens P30301
Y2H Array
32814053
Intra
HSPA2 P54652 MIP Homo sapiens P30301
Y2H Pooling
32814053
Intra
HSPA2 P54652 AK8 Homo sapiens Q96MA6
Y2H Array
32814053
Intra
HSPA2 P54652 AK8 Homo sapiens Q96MA6
Y2H Pooling
32814053
Intra
HSPA2 P54652 AK8 Homo sapiens Q96MA6
Validated Y2H
32814053
Intra
HSPA2 P54652 ZNF296 Homo sapiens Q8WUU4
Validated Y2H
32814053
Intra
HSPA2 P54652 ZNF296 Homo sapiens Q8WUU4
Y2H Array
32814053
Intra
HSPA2 P54652 ZNF296 Homo sapiens Q8WUU4
Y2H Pooling
32814053
Intra
HSPA2 P54652 TAF8 Homo sapiens Q7Z7C8-2
Y2H Pooling
32814053
Intra
HSPA2 P54652 TAF8 Homo sapiens Q7Z7C8-2
Validated Y2H
32814053
Intra
HSPA2 P54652 TAF8 Homo sapiens Q7Z7C8-2
Y2H Array
32814053
Intra
HSPA2 P54652 RANGRF Homo sapiens Q9HD47-3
Validated Y2H
32814053
Intra
HSPA2 P54652 RANGRF Homo sapiens Q9HD47-3
Y2H Pooling
32814053
Intra
HSPA2 P54652 RANGRF Homo sapiens Q9HD47-3
Y2H Array
32814053
Intra
HSPA2 P54652 PSMF1 Homo sapiens Q92530
Validated Y2H
32814053
Intra
HSPA2 P54652 PSMF1 Homo sapiens Q92530
Y2H Array
32814053
Intra
HSPA2 P54652 PSMF1 Homo sapiens Q92530
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

HSPA2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83311 HspA2 Antibody (YA3056) WB, IHC-P Human, Mouse, Rat
HY-P83311A HspA2 Antibody (YA3056)(PBS only) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Varicocele

  • Scrotal Varices

  • Varicoceles

  • Varicocele Of Scrotum

  • Scrotal Varicocele
Visceral Leishmaniasis

  • Kala-Azar

  • Leishmaniasis, Visceral

  • Infection By Visceral Leishmaniasis

  • Leishmaniasis Visceral

  • Sahib Disease

  • Ponos

  • Burdwan Fever

  • Mard El Bicha

  • Sirkari Disease

  • Indian Visceral Leishmaniasis

  • Dumdum Fever

  • Visceral Leishmaniasis Due To Leishmania Donovani
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152153 GRP78-IN-3 Inhibitor 99.88% Unkown
HY-RS06427 HSPA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20423 Hspa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25750 Hspa1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26932 Hspa2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HSPA2 VGNC VGNC:50533
Rattus norvegicus HSPA2 RGD RGD:620664
Mus musculus HSPA2 MGD MGI:96243
Felis catus HSPA2 VGNC VGNC:80953