2. Gene
  3. POLA2 - DNA polymerase alpha 2, accessory subunit Gene

POLA2 - DNA polymerase alpha 2, accessory subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 23649 | Gene type: protein coding

About POLA2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,261,962-65,305,985 (from NCBI)

This gene has 8 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in lymph node (RPKM 4.3), appendix (RPKM 2.9) and 25 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in DNA replication, synthesis of RNA primer. Located in cytosol and nucleoplasm. Part of alpha DNA polymerase:primase complex. [provided by Alliance of Genome Resources, Apr 2022]

POLA2 Products(1)

mRNA Protein Name
NM_002689.4 NP_002680.2 DNA polymerase alpha subunit B

POLA2 Protein Structure

Pol_alpha_B_N

Pol_alpha_B_N: DNA polymerase alpha subunit B N-terminal (15 - 248)

DNA_pol_E_B

DNA_pol_E_B: DNA polymerase alpha/epsilon subunit B (342 - 549)

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  • 598 a.a.
Protein Preferred Names Protein Names

DNA polymerase alpha subunit B

DNA polymerase alpha 70 kDa subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10817 POLA2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus POLA2 MGD MGI:99690
Felis catus POLA2 VGNC VGNC:81958
Macaca mulatta POLA2 VGNC VGNC:101380
Rattus norvegicus POLA2 RGD RGD:621817
Canis familiaris POLA2 VGNC VGNC:44772
Bos taurus POLA2 VGNC VGNC:33111