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TRIM38 - tripartite motif containing 38 Gene

Also Known as RNF15; RORET

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10475

About TRIM38

This gene has 1 transcript (splice variant), 103 orthologues and 80 paralogues. Ubiquitous expression in spleen (RPKM 9.0), lymph node (RPKM 8.4) and 24 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]

TRIM38 Products (1)

mRNA	Protein	Name
NM_006355.5	NP_006346.1	E3 ubiquitin-protein ligase TRIM38

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23275563	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	18248090	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM38 Protein Structure

zf-C3HC4_4

zf-B_box

PRY

SPRY

0
100
200
300
400
465 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIM38	RING-type E3 ubiquitin transferase TRIM38

TRIM38 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM38	O00635	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	25416956
Intra	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	TRIM38	O00635	GC20	Homo sapiens	Q6FG85	Validated Y2H	25416956
Intra	TRIM38	O00635	GC20	Homo sapiens	Q6FG85	Y2H Array	25416956
Intra	TRIM38	O00635	GC20	Homo sapiens	Q6FG85	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	MTURN	Homo sapiens	Q8N3F0	Validated Y2H	32296183
Intra	TRIM38	O00635	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	TRIM38	O00635	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	TRIM38	O00635	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
Intra	TRIM38	O00635	TSPYL4	Homo sapiens	Q9UJ04	Validated Y2H	32296183
Intra	TRIM38	O00635	HSPA8	Homo sapiens	P11142	Validated Y2H	32296183
Intra	TRIM38	O00635	HSPA8	Homo sapiens	P11142	Y2H Array	25416956
Intra	TRIM38	O00635	HSPA1L	Homo sapiens	P34931	Validated Y2H	32296183
Intra	TRIM38	O00635	HSPA2	Homo sapiens	P54652	Validated Y2H	25416956
Intra	TRIM38	O00635	HSPA2	Homo sapiens	P54652	Y2H Array	31515488
Intra	TRIM38	O00635	HSPA2	Homo sapiens	P54652	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	TRIM38	O00635	PSMA4	Homo sapiens	P25789	Y2H Array	32296183
Intra	TRIM38	O00635	PSMA4	Homo sapiens	P25789	Validated Y2H	32296183
Intra	TRIM38	O00635	PIAS4	Homo sapiens	Q8N2W9	Y2H Prey Pooling	32296183
Intra	TRIM38	O00635	PIAS4	Homo sapiens	Q8N2W9	Validated Y2H	32296183
Intra	TRIM38	O00635	PIAS4	Homo sapiens	Q8N2W9	Y2H Array	32296183
Intra	TRIM38	O00635	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Validated Y2H	25416956
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Validated Y2H	32296183
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Array	25416956
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Array	29892012
Intra	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Array	31515488
Intra	TRIM38	O00635	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	TRIM38	O00635	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	TRIM38	O00635	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
Intra	TRIM38	O00635	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	TRIM38	O00635	ZNF764	Homo sapiens	Q96H86	Validated Y2H	32296183
Intra	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	23275563
Intra	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	TRIM38	O00635	STXBP1	Homo sapiens	P61764	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fanconi Renotubular Syndrome 2	FRTS2 Fanconi Renotubular Syndrome, Type 2
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15042	TRIM38 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21961	Trim38 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28478	Trim38 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRIM38	VGNC	VGNC:78548
Bos taurus	TRIM38	VGNC	VGNC:36333
Rattus norvegicus	TRIM38	RGD	RGD:1596868
Canis familiaris	TRIM38	VGNC	VGNC:47819
Felis catus	TRIM38	VGNC	VGNC:66537
Mus musculus	TRIM38	MGD	MGI:2684869
Others	TRIM38	NCBI