2. Gene
  3. RFC5 - replication factor C subunit 5 Gene

RFC5 - replication factor C subunit 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RFC36

Gene ID: 5985 | Gene type: protein coding

About RFC5

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:118,016,703-118,041,448 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 10.5), thyroid (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

RFC5 Products(6)

mRNA Protein Name
NM_001130112.4 NP_001123584.1 replication factor C subunit 5 isoform 3
NM_001130113.3 NP_001123585.1 replication factor C subunit 5 isoform 2
NM_001206801.3 NP_001193730.1 replication factor C subunit 5 isoform 4
NM_001346815.2 NP_001333744.1 replication factor C subunit 5 isoform 5
NM_007370.7 NP_031396.1 replication factor C subunit 5 isoform 1
NM_181578.5 NP_853556.2 replication factor C subunit 5 isoform 2

RFC5 Protein Structure

AAA

AAA: ATPase family associated with various cellular activities (AAA) (56 - 173)

Rep_fac_C

Rep_fac_C: Replication factor C C-terminal domain (241 - 329)

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  • 340 a.a.
Protein Preferred Names Protein Names

replication factor C subunit 5

A1 36 kDa subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11869 RFC5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RFC5 VGNC VGNC:76904
Rattus norvegicus RFC5 RGD RGD:1309280
Mus musculus RFC5 MGD MGI:1919401
Felis catus RFC5 VGNC VGNC:69298
Canis familiaris RFC5 VGNC VGNC:45496
Bos taurus RFC5 VGNC VGNC:33889