RFC4 - replication factor C subunit 4 Gene

Also Known as A1; RFC37

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5984

About RFC4

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,789,900-186,806,482 (from NCBI)

This gene has 13 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 108.6), ovary (RPKM 88.0) and 25 other tissues.

Summary

The elongation of primed DNA templates by DNA Polymerase delta and DNA Polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

RFC4 Products (2)

mRNA Protein Name
NM_002916.5 NP_002907.1 replication factor C subunit 4
NM_181573.3 NP_853551.1 replication factor C subunit 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to DNA clamp loader activity IDA
IDA: Inferred from direct assay
12930902 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9488738 GOA
contributes to single-stranded DNA helicase activity IDA
IDA: Inferred from direct assay
12930902 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA-templated DNA replication IDA
IDA: Inferred from direct assay
9488738 GOA
involved in positive regulation of DNA-directed DNA polymerase activity IDA
IDA: Inferred from direct assay
12930902 GOA
Cellular Component GO Annotation Evidence References Source
part of Ctf18 RFC-like complex IDA
IDA: Inferred from direct assay
12930902 GOA
part of DNA replication factor C complex IDA
IDA: Inferred from direct assay
9488738 GOA
part of DNA replication factor C complex IPI
IPI: Inferred from physical interaction
9488738 GOA
part of Elg1 RFC-like complex IDA
IDA: Inferred from direct assay
23277426 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RFC4 Protein Structure

AAA

AAA: ATPase family associated with various cellular activities (AAA) (74 - 200)

Rep_fac_C

Rep_fac_C: Replication factor C C-terminal domain (268 - 354)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
Protein Preferred Names Protein Names

replication factor C subunit 4

  • A1 37 kDa subunit

RFC4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RFC4 P35249 RFC3 Homo sapiens P40938
Pull Down
9488738
Intra
RFC4 P35249 RFC3 Homo sapiens P40938
Anti Tag CoIP
33961781
Intra
RFC4 P35249 RFC3 Homo sapiens P40938
Anti Tag CoIP
28514442
Intra
RFC4 P35249 RFC3 Homo sapiens P40938
Validated Y2H
32296183
Intra
RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Y2H Array
32296183
Intra
RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Y2H
21516116
Intra
RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
25416956
Intra
RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Validated Y2H
25416956
Intra
RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
32296183
Intra
RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Validated Y2H
32296183
Intra
RFC4 P35249 RFC2 Homo sapiens P35250
Anti Tag CoIP
33961781
Intra
RFC4 P35249 RFC2 Homo sapiens P35250
Pull Down
9488738
Intra
RFC4 P35249 RFC2 Homo sapiens P35250
Pull Down
15655353
Intra
RFC4 P35249 RFC2 Homo sapiens P35250
CoIP
15655353
Intra
RFC4 P35249 RFC5 Homo sapiens P40937
Anti Tag CoIP
33961781
Intra
RFC4 P35249 RFC5 Homo sapiens P40937
Crosslink
30021884
Intra
RFC4 P35249 RFC5 Homo sapiens P40937
Y2H Array
29892012
Intra
RFC4 P35249 RFC5 Homo sapiens P40937
Y2H Pooling
16189514
Intra
RFC4 P35249 RFC5 Homo sapiens P40937
Pull Down
9488738
Intra
RFC4 P35249 RFC5 Homo sapiens P40937
Validated Y2H
32296183
Intra
RFC4 P35249 RFC5 Homo sapiens P40937
Y2H Array
31515488
Intra
RFC4 P35249 RFC5 Homo sapiens P40937
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11868 RFC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22298 Rfc4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28821 Rfc4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RFC4 RGD RGD:1310142
Mus musculus RFC4 MGD MGI:2146571
Macaca mulatta RFC4 VGNC VGNC:76903
Felis catus RFC4 VGNC VGNC:69297
Canis familiaris RFC4 VGNC VGNC:45495
Bos taurus RFC4 VGNC VGNC:33888
Others RFC4 NCBI