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XAF1 - XIAP associated factor 1 Gene

Also Known as BIRC4BP; XIAPAF1; HSXIAPAF1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54739

About XAF1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:6,755,447-6,775,647 (from NCBI)

This gene has 19 transcripts (splice variants), 166 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 13.4), lung (RPKM 8.3) and 24 other tissues.

Summary

This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of Apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during Apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the Apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

XAF1 Products (9)

mRNA	Protein	Name
NM_001353134.2	NP_001340063.1	XIAP-associated factor 1 isoform 3
NM_001353135.1	NP_001340064.1	XIAP-associated factor 1 isoform 1
NM_001353136.2	NP_001340065.1	XIAP-associated factor 1 isoform 4
NM_001353137.2	NP_001340066.1	XIAP-associated factor 1 isoform 5
NM_001353138.2	NP_001340067.1	XIAP-associated factor 1 isoform 5
NM_001353139.2	NP_001340068.1	XIAP-associated factor 1 isoform 6
NM_001353140.2	NP_001340069.1	XIAP-associated factor 1 isoform 7
NM_017523.5	NP_059993.2	XIAP-associated factor 1 isoform 1
NM_199139.4	NP_954590.1	XIAP-associated factor 1 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables molecular sequestering activity	IDA IDA: Inferred from direct assay	36394357	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	36394357	GOA
involved in response to interferon-beta	IDA IDA: Inferred from direct assay	18035482	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XAF1 Protein Structure

zf-TRAF

0
100
200
301 a.a.

Protein Preferred Names	Protein Names
XIAP-associated factor 1	BIRC4-binding protein

XAF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	XAF1	Q6GPH4	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
Intra	XAF1	Q6GPH4	RNF166	Homo sapiens	Q96A37	Validated Y2H	32296183
Intra	XAF1	Q6GPH4	RNF166	Homo sapiens	Q96A37	Y2H Array	32296183
Intra	XAF1	Q6GPH4	RNF166	Homo sapiens	Q96A37	Anti Tag CoIP	33961781
Intra	XAF1	Q6GPH4	RNF166	Homo sapiens	Q96A37	Y2H Prey Pooling	32296183
Intra	XAF1	Q6GPH4	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	XAF1	Q6GPH4	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	XAF1	Q6GPH4	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	XAF1	Q6GPH4	AKT1	Homo sapiens	P31749	Anti Tag CoIP	33961781
Intra	XAF1	Q6GPH4	VCP	Homo sapiens	P55072	Y2H Array	32296183
Intra	XAF1	Q6GPH4	VCP	Homo sapiens	P55072	Y2H Prey Pooling	32296183
Intra	XAF1	Q6GPH4	GLS2	Homo sapiens	Q9UI32	Validated Y2H	32296183
Intra	XAF1	Q6GPH4	BIRC7	Homo sapiens	Q96CA5	Y2H Prey Pooling	32296183
Intra	XAF1	Q6GPH4	BIRC7	Homo sapiens	Q96CA5	Validated Y2H	32296183
Intra	XAF1	Q6GPH4	BIRC7	Homo sapiens	Q96CA5	Y2H Array	32296183
Intra	XAF1	Q6GPH4	LRSAM1	Homo sapiens	Q6UWE0	Validated Y2H	32296183
Intra	XAF1	Q6GPH4	RNF114	Homo sapiens	Q9Y508	Anti Tag CoIP	33961781
Intra	XAF1	Q6GPH4	RNF114	Homo sapiens	Q9Y508	Validated Y2H	32296183
Intra	XAF1	Q6GPH4	RNF114	Homo sapiens	Q9Y508	Y2H Array	32296183
Intra	XAF1	Q6GPH4	RNF114	Homo sapiens	Q9Y508	Y2H Prey Pooling	32296183
Intra	XAF1	Q6GPH4	TRIM50	Homo sapiens	Q86XT4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cataract 37	CTRCT37 Cca5 Cataract, Congenital, Cerulean Type, 5 Cataract 37, Autosomal Dominant Congenital Cataract Cerulean Type 5
Exocervical Carcinoma	Carcinoma Of Exocervix Carcinoma Of The Exocervix
Alacrima, Achalasia, And Mental Retardation Syndrome	AAMR Alacrima, Achalasia, And Intellectual Disability Syndrome Alacrima, Achalasia, And Impaired Intellectual Development Syndrome Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15864	XAF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21459	Xaf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27977	Xaf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	XAF1	MGD	MGI:3772572
Macaca mulatta	XAF1	VGNC	VGNC:99332
Bos taurus	XAF1	VGNC	VGNC:36982
Canis familiaris	XAF1	VGNC	VGNC:48446
Rattus norvegicus	XAF1	RGD	RGD:1585988
Others	XAF1	NCBI