2. Gene
  3. RNF114 - ring finger protein 114 Gene

RNF114 - ring finger protein 114 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZNF313; PSORS12

Gene ID: 55905 | Gene type: protein coding

About RNF114

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,936,397-49,953,885 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 40.7), spleen (RPKM 29.3) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol and plasma membrane. Biomarker of male infertility. [provided by Alliance of Genome Resources, Apr 2022]

RNF114 Products(1)

mRNA Protein Name
NM_018683.4 NP_061153.1 E3 ubiquitin-protein ligase RNF114

RNF114 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (29 - 67)

zf-Di19

zf-Di19: Drought induced 19 protein (Di19), zinc-binding (140 - 200)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF114

RING-type E3 ubiquitin transferase RNF114

Related Diseases

Diseases Alias
Psoriasis 12

PSORS12

Psoriasis Susceptibility 12

Psoriasis 12, Susceptibility To
Miliaria Crystallina
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115715 EN219 98.56% Unkown
HY-156499 RNF114 ligand 1 ≥95.0% Unkown
HY-RS12039 RNF114 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RNF114 VGNC VGNC:45623
Macaca mulatta RNF114 VGNC VGNC:76725
Felis catus RNF114 VGNC VGNC:64665
Rattus norvegicus RNF114 RGD RGD:1303139
Mus musculus RNF114 MGD MGI:1933159
Bos taurus RNF114 VGNC VGNC:34012
Others RNF114 NCBI