RNF114 - ring finger protein 114 Gene

Also Known as ZNF313; PSORS12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55905

About RNF114

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,936,397-49,953,885 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 40.7), spleen (RPKM 29.3) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol and plasma membrane. Biomarker of male infertility. [provided by Alliance of Genome Resources, Apr 2022]

RNF114 Products (1)

mRNA Protein Name
NM_018683.4 NP_061153.1 E3 ubiquitin-protein ligase RNF114

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19549727 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF114 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (29 - 67)

zf-Di19

zf-Di19: Drought induced 19 protein (Di19), zinc-binding (140 - 200)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF114

  • RING-type E3 ubiquitin transferase RNF114

RNF114 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF114 Q9Y508 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra
RNF114 Q9Y508 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra
RNF114 Q9Y508 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra
RNF114 Q9Y508 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra
RNF114 Q9Y508 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra
RNF114 Q9Y508 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra
RNF114 Q9Y508 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
Intra
RNF114 Q9Y508 UBE2D1 Homo sapiens P51668
Y2H
19549727
Intra
RNF114 Q9Y508 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra
RNF114 Q9Y508 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra
RNF114 Q9Y508 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Psoriasis 12

  • PSORS12

  • Psoriasis Susceptibility 12

  • Psoriasis 12, Susceptibility To
Miliaria Crystallina
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-28328 E3 ligase Ligand 72 / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RNF114 VGNC VGNC:45623
Macaca mulatta RNF114 VGNC VGNC:76725
Felis catus RNF114 VGNC VGNC:64665
Rattus norvegicus RNF114 RGD RGD:1303139
Mus musculus RNF114 MGD MGI:1933159
Bos taurus RNF114 VGNC VGNC:34012
Others RNF114 NCBI