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Cat. No.: HY-28328

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E3 ligase Ligand 72

E3 ligase Ligand 72 is a covalent E3 ligase ligand. E3 ligase Ligand 72 can be used to synthesize PROTAC ML 2-23 (HY-153582).

For research use only. We do not sell to patients.

CAS No.: 3066017-23-7
Formula: C₁₉H₁₆BrClN₂O₄
Molecular Weight:451.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

E3 ligase Ligand 72 Chemical Structure

CAS No.: 3066017-23-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
Chemical Information
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Biological Activity

Description

E3 ligase Ligand 72 is a covalent E3 ligase ligand. E3 ligase Ligand 72 can be used to synthesize PROTAC ML 2-23 (HY-153582)^[1].

IC₅₀ & Target

RNF114

All Ligands for E3 Ligase Isoforms :

Chemical Information

CAS No. 3066017-23-7
Molecular Weight 451.70
Formula C₁₉H₁₆BrClN₂O₄
SMILES

O=C(O)COC1=CC=C(C2CC(C3=CC=C(Br)C=C3)=NN2C(CCl)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Luo M, et, al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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E3 ligase Ligand 72

All Ligands for E3 Ligase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

E3 ligase Ligand 72 Related Classifications

HY-28328 Related Classifications