TRIM50 - tripartite motif containing 50 Gene

Also Known as TRIM50A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 135892

Summary

Enables identical protein binding activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within regulation of establishment of protein localization. Predicted to be located in aggresome. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jun 2026]
Biased expression in stomach (RPKM 3.4), testis (RPKM 2.8) and 8 other tissues.

TRIM50 Products (3)

mRNA Protein Name
NM_001281450.1 NP_001268379.1 E3 ubiquitin-protein ligase TRIM50 isoform b
NM_001281451.1 NP_001268380.1 E3 ubiquitin-protein ligase TRIM50 isoform a
NM_178125.3 NP_835226.2 E3 ubiquitin-protein ligase TRIM50 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22829933 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM50 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRIM50 Q86XT4 IQUB Homo sapiens Q8NA54
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
TRIM50 Q86XT4 ZNF438 Homo sapiens Q7Z4V0
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 ZNF438 Homo sapiens Q7Z4V0
Y2H Array
32296183
Intra
TRIM50 Q86XT4 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
TRIM50 Q86XT4 UBE2E2 Homo sapiens Q96LR5
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 UBE2E2 Homo sapiens Q96LR5
Y2H Array
32296183
Intra
TRIM50 Q86XT4 UBE2E2 Homo sapiens Q96LR5
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra
TRIM50 Q86XT4 XAF1 Homo sapiens Q6GPH4
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 XAF1 Homo sapiens Q6GPH4
Y2H Array
32296183
Intra
TRIM50 Q86XT4 ARHGAP45 Homo sapiens Q92619
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 UBE2E3 Homo sapiens Q969T4
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
TRIM50 Q86XT4 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
TRIM50 Q86XT4 TSSK3 Homo sapiens Q96PN8
Y2H Array
32296183
Intra
TRIM50 Q86XT4 TSSK3 Homo sapiens Q96PN8
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
TRIM50 Q86XT4 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
TRIM50 Q86XT4 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 L3MBTL2 Homo sapiens Q969R5
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 UBE2D4 Homo sapiens Q9Y2X8
Y2H Array
32296183
Intra
TRIM50 Q86XT4 UBTD1 Homo sapiens Q9HAC8
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 GCC1 Homo sapiens Q96CN9
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 KLHL2 Homo sapiens O95198
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 KLHL2 Homo sapiens O95198
Y2H Array
32296183
Intra
TRIM50 Q86XT4 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 TRIM50 Homo sapiens Q86XT4
Validated Y2H
32296183
Intra
TRIM50 Q86XT4 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
Intra
TRIM50 Q86XT4 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
Intra
TRIM50 Q86XT4 TRIM50 Homo sapiens Q86XT4
Y2H
22829933
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15053 TRIM5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-185123 Pig TRIM56 mRNA / Unkown
HY-RS15019 TRIM10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15045 TRIM40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15054 TRIM52 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15055 TRIM54 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15056 TRIM55 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15057 TRIM56 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15058 TRIM58 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15059 TRIM59 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15061 TRIM60 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18412 Trim5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21963 Trim56 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24893 Trim5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28480 Trim56 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown