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UBE2E3 - ubiquitin conjugating enzyme E2 E3 Gene

Also Known as UBCH9; UbcM2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10477

About UBE2E3

Cytogenetic location: 2q31.3 Genomic coordinates (GRCh38): 2:180,980,360-181,063,425 (from NCBI)

This gene has 14 transcripts (splice variants), 164 orthologues and 12 paralogues. Ubiquitous expression in gall bladder (RPKM 6.0), thyroid (RPKM 5.9) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]

UBE2E3 Products (4)

mRNA	Protein	Name
NM_001278554.2	NP_001265483.1	ubiquitin-conjugating enzyme E2 E3
NM_001278555.2	NP_001265484.1	ubiquitin-conjugating enzyme E2 E3
NM_006357.4	NP_006348.1	ubiquitin-conjugating enzyme E2 E3
NM_182678.3	NP_872619.1	ubiquitin-conjugating enzyme E2 E3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20061386	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2E3 Protein Structure

UQ_con

0
100
207 a.a.

Protein Preferred Names	Protein Names
ubiquitin-conjugating enzyme E2 E3	E2 ubiquitin-conjugating enzyme E3

UBE2E3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UBE2E3	Q969T4	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	UBE2E3	Q969T4	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	33961781
Intra	UBE2E3	Q969T4	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	28514442
Intra	UBE2E3	Q969T4	OTUB1	Homo sapiens	Q96FW1	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	UBE2E3	Q969T4	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	UBE2E3	Q969T4	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	UBE2E3	Q969T4	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	UBE2E3	Q969T4	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	CHFR	Homo sapiens	Q96EP1-2	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	CHFR	Homo sapiens	Q96EP1-2	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	CHFR	Homo sapiens	Q96EP1-2	Y2H Array	32296183
Intra	UBE2E3	Q969T4	PGPEP1	Homo sapiens	Q9NXJ5-2	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	RNF25	Homo sapiens	Q96BH1	Anti Tag CoIP	28514442
Intra	UBE2E3	Q969T4	RNF25	Homo sapiens	Q96BH1	Y2H Array	19549727
Intra	UBE2E3	Q969T4	RNF25	Homo sapiens	Q96BH1	Anti Tag CoIP	33961781
Intra	UBE2E3	Q969T4	RNF115	Homo sapiens	Q9Y4L5	Y2H Array	32296183
Intra	UBE2E3	Q969T4	RNF115	Homo sapiens	Q9Y4L5	Y2H Array	19690564
Intra	UBE2E3	Q969T4	RNF115	Homo sapiens	Q9Y4L5	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	RNF115	Homo sapiens	Q9Y4L5	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	RNF185	Homo sapiens	Q96GF1	Y2H Array	31515488
Intra	UBE2E3	Q969T4	RNF185	Homo sapiens	Q96GF1	Y2H Prey Pooling	25416956
Intra	UBE2E3	Q969T4	RNF185	Homo sapiens	Q96GF1	Y2H Array	19549727
Intra	UBE2E3	Q969T4	RNF185	Homo sapiens	Q96GF1	Validated Y2H	25416956
Intra	UBE2E3	Q969T4	RNF185	Homo sapiens	Q96GF1	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	RNF185	Homo sapiens	Q96GF1	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	RNF185	Homo sapiens	Q96GF1	Y2H Array	32296183
Intra	UBE2E3	Q969T4	MID1	Homo sapiens	O15344	Validated Y2H	25416956
Intra	UBE2E3	Q969T4	MID1	Homo sapiens	O15344	Y2H Array	25416956
Intra	UBE2E3	Q969T4	MID1	Homo sapiens	O15344	Y2H Array	32296183
Intra	UBE2E3	Q969T4	MID1	Homo sapiens	O15344	Y2H Prey Pooling	25416956
Intra	UBE2E3	Q969T4	MID1	Homo sapiens	O15344	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
Intra	UBE2E3	Q969T4	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	RNF5	Homo sapiens	Q99942	Validated Y2H	25416956
Intra	UBE2E3	Q969T4	RNF5	Homo sapiens	Q99942	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
Intra	UBE2E3	Q969T4	RNF5	Homo sapiens	Q99942	Y2H Array	25416956
Intra	UBE2E3	Q969T4	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	UBE2E3	Q969T4	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	UBE2E3	Q969T4	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	UBE2E3	Q969T4	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	UBE2E3	Q969T4	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	UBE2E3	Q969T4	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	UBE2E3	Q969T4	TRIM62	Homo sapiens	Q9BVG3	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	TRIM62	Homo sapiens	Q9BVG3	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	TRIM62	Homo sapiens	Q9BVG3	Y2H Array	32296183
Intra	UBE2E3	Q969T4	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	UBE2E3	Q969T4	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	UBE2E3	Q969T4	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	UBE2E3	Q969T4	RNF10	Homo sapiens	Q8N5U6	Anti Tag CoIP	33961781
Intra	UBE2E3	Q969T4	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	UBE2E3	Q969T4	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	UBE2E3	Q969T4	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	UBE2E3	Q969T4	RNF2	Homo sapiens	Q99496	Y2H Array	32296183
Intra	UBE2E3	Q969T4	RNF2	Homo sapiens	Q99496	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	RNF2	Homo sapiens	Q99496	Y2H Array	19549727
Intra	UBE2E3	Q969T4	RNF2	Homo sapiens	Q99496	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	UBE2E3	Q969T4	WBP2	Homo sapiens	Q969T9	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	WBP2	Homo sapiens	Q969T9	Y2H Array	32296183
Intra	UBE2E3	Q969T4	WBP2	Homo sapiens	Q969T9	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	25416956
Intra	UBE2E3	Q969T4	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	WWP2	Homo sapiens	O00308	Y2H Array	32296183
Intra	UBE2E3	Q969T4	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	UBE2E3	Q969T4	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	UBE2E3	Q969T4	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	UBE2E3	Q969T4	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	UBE2E3	Q969T4	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	UBE2E3	Q969T4	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	UBE2E3	Q969T4	RNF220	Homo sapiens	Q5VTB9	Anti Tag CoIP	33961781
Intra	UBE2E3	Q969T4	RNF220	Homo sapiens	Q5VTB9	Anti Tag CoIP	28514442
Intra	UBE2E3	Q969T4	RNF220	Homo sapiens	Q5VTB9	Y2H	19549727
Intra	UBE2E3	Q969T4	TRIM50	Homo sapiens	Q86XT4	Y2H Prey Pooling	32296183
Intra	UBE2E3	Q969T4	TRIM50	Homo sapiens	Q86XT4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15344	UBE2E3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBE2E3	RGD	RGD:1308894
Felis catus	UBE2E3	VGNC	VGNC:107686
Mus musculus	UBE2E3	MGD	MGI:107412
Canis familiaris	UBE2E3	VGNC	VGNC:53110
Macaca mulatta	UBE2E3	VGNC	VGNC:99418
Bos taurus	UBE2E3	VGNC	VGNC:56154
Others	UBE2E3	NCBI