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RNF185 - ring finger protein 185 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 91445

About RNF185

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,160,182-31,207,019 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 37.5), prostate (RPKM 19.7) and 25 other tissues.

Summary

Enables ubiquitin binding activity; ubiquitin protein Ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in positive regulation of ERAD pathway; protein autoubiquitination; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

RNF185 Products (2)

mRNA	Protein	Name
NM_001135825.2	NP_001129297.1	E3 ubiquitin-protein ligase RNF185 isoform 2
NM_152267.4	NP_689480.2	E3 ubiquitin-protein ligase RNF185 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19549727	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	24019521	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	27485036	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	24019521	GOA
enables ubiquitin-like protein conjugating enzyme binding	IPI IPI: Inferred from physical interaction	24019521	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IGI IGI: Inferred from genetic interaction	24019521	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	28273161	GOA
involved in positive regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	27485036	GOA
involved in positive regulation of innate immune response	IDA IDA: Inferred from direct assay	28273161	GOA
involved in positive regulation of type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	28273161	GOA
involved in protein K27-linked ubiquitination	IDA IDA: Inferred from direct assay	28273161	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	24019521	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	24019521	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	24019521	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF185 Protein Structure

zf-C3HC4_2

0
100
192 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase RNF185	BSK65-MONO1

RNF185 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF185	Q96GF1	TMBIM6	Homo sapiens	P55061	Anti Tag CoIP	28514442
Intra	RNF185	Q96GF1	TMBIM6	Homo sapiens	P55061	Anti Tag CoIP	33961781
Intra	RNF185	Q96GF1	UBE2E2	Homo sapiens	Q96LR5	Y2H Array	19549727
Intra	RNF185	Q96GF1	UBE2E2	Homo sapiens	Q96LR5	Validated Y2H	32296183
Intra	RNF185	Q96GF1	CMTM5	Homo sapiens	Q96DZ9	Validated Y2H	25416956
Intra	RNF185	Q96GF1	ARL6IP5	Homo sapiens	O75915	Validated Y2H	25416956
Intra	RNF185	Q96GF1	ARL6IP5	Homo sapiens	O75915	Y2H Prey Pooling	25416956
Intra	RNF185	Q96GF1	ARL6IP5	Homo sapiens	O75915	Y2H Array	25416956
Intra	RNF185	Q96GF1	UBE2D2	Homo sapiens	P62837	Y2H Array	19549727
Intra	RNF185	Q96GF1	UBE2E3	Homo sapiens	Q969T4	Y2H Array	25416956
Intra	RNF185	Q96GF1	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	RNF185	Q96GF1	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
Intra	RNF185	Q96GF1	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	RNF185	Q96GF1	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	32296183
Intra	RNF185	Q96GF1	YIPF2	Homo sapiens	Q9BWQ6	Y2H Prey Pooling	25416956
Intra	RNF185	Q96GF1	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	32296183
Intra	RNF185	Q96GF1	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	25416956
Intra	RNF185	Q96GF1	YIPF4	Homo sapiens	Q9BSR8	Y2H Prey Pooling	25416956
Intra	RNF185	Q96GF1	YIPF4	Homo sapiens	Q9BSR8	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12069	RNF185 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RNF185	VGNC	VGNC:64686
Rattus norvegicus	RNF185	RGD	RGD:1564777
Mus musculus	RNF185	MGD	MGI:1922078
Macaca mulatta	RNF185	VGNC	VGNC:76841
Bos taurus	RNF185	VGNC	VGNC:34042
Canis familiaris	RNF185	VGNC	VGNC:45648
Others	RNF185	NCBI