ARL6IP5 - ADP ribosylation factor like GTPase 6 interacting protein 5 Gene

Also Known as JWA; jmx; hp22; PRAF3; Yip6b; DERP11; HSPC127; addicsin; GTRAP3-18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10550

About ARL6IP5

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:69,084,937-69,106,092 (from NCBI)

This gene has 5 transcripts (splice variants), 280 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 104.3), heart (RPKM 86.8) and 25 other tissues.

Summary

Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the Cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]

ARL6IP5 Products (1)

mRNA	Protein	Name
NM_006407.4	NP_006398.1	PRA1 family protein 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	12562531	GOA
involved in intrinsic apoptotic signaling pathway in response to oxidative stress	IDA IDA: Inferred from direct assay	18387645	GOA
involved in negative regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	18387645	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18387645	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	18387645	GOA
involved in positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	18387645	GOA
acts upstream of or within protein transport	IDA IDA: Inferred from direct assay	18167356	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL6IP5 Protein Structure

PRA1

0
100
188 a.a.

Protein Preferred Names	Protein Names
PRA1 family protein 3	ADP-ribosylation factor GTPase 6 interacting protein 5

ARL6IP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARL6IP5	O75915	MIEF1	Homo sapiens	Q9NQG6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Laurence-Moon Syndrome	LNMS Laurence-Moon-Biedl Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00996	ARL6IP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARL6IP5	VGNC	VGNC:110384
Felis catus	ARL6IP5	VGNC	VGNC:102001
Mus musculus	ARL6IP5	MGD	MGI:1929501
Canis familiaris	ARL6IP5	VGNC	VGNC:38120
Rattus norvegicus	ARL6IP5	RGD	RGD:708572
Bos taurus	ARL6IP5	VGNC	VGNC:26151
Others	ARL6IP5	NCBI